Skip to main content
main-content
Erschienen in: Pädiatrie 1/2014

02.09.2014 | Fortbildung

Physiologische Infektanfälligkeit oder Immundefekt?

Ungewöhnliche Infektionen

verfasst von: Prof. Dr. med. Ulrich Baumann

Erschienen in: Pädiatrie | Sonderheft 1/2014

Einloggen, um Zugang zu erhalten

Zusammenfassung

Der Titel lässt einen stutzen: Der Begriff „Infektanfälligkeit“ impliziert nämlich eine — wodurch auch immer — entstandene Abwehrschwäche gegenüber infektiösen Erregern, während „physiologisch“ auf Verhältnisse hinweist, die beim Gesunden vorliegen. Kann man also gleichzeitig gesund sein und ein geschwächtes Immunsystem haben? Was ist nun wissenschaftlich betrachtet „Infektanfälligkeit“?
Literatur
1.
Zurück zum Zitat Okkes IM, Oskam SK, Lamberts H. The probability of specific diagnoses for patients presenting with common symptoms to dutch family physicians. J Fam Pract. 2002 Jan;51(1):31–6. PubMed Okkes IM, Oskam SK, Lamberts H. The probability of specific diagnoses for patients presenting with common symptoms to dutch family physicians. J Fam Pract. 2002 Jan;51(1):31–6. PubMed
2.
Zurück zum Zitat Casanova JL, Abel L. The human model: A genetic dissection of immunity to infection in natural conditions. Nat Rev Immunol. 2004 Jan;4(1):55–66. PubMedCrossRef Casanova JL, Abel L. The human model: A genetic dissection of immunity to infection in natural conditions. Nat Rev Immunol. 2004 Jan;4(1):55–66. PubMedCrossRef
3.
Zurück zum Zitat Nafstad P, Hagen JA, Oie L, Magnus P, Jaakkola JJ. Day care centers and respiratory health. Pediatrics. 1999 Apr;103(4 Pt 1):753–8. PubMedCrossRef Nafstad P, Hagen JA, Oie L, Magnus P, Jaakkola JJ. Day care centers and respiratory health. Pediatrics. 1999 Apr;103(4 Pt 1):753–8. PubMedCrossRef
4.
Zurück zum Zitat The hamburg cholera epidemic. Br Med J. 1893 Feb 25;1(1678):429–30. The hamburg cholera epidemic. Br Med J. 1893 Feb 25;1(1678):429–30.
5.
Zurück zum Zitat Smith GJ, Bahl J, Vijaykrishna D, Zhang J, Poon LL, Chen H, et al. Dating the emergence of pandemic influenza viruses. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11709–12. PubMedCentralPubMedCrossRef Smith GJ, Bahl J, Vijaykrishna D, Zhang J, Poon LL, Chen H, et al. Dating the emergence of pandemic influenza viruses. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11709–12. PubMedCentralPubMedCrossRef
6.
Zurück zum Zitat Caulfield LE, de Onis M, Blossner M, Black RE. Undernutrition as an underlying cause of child deaths associated with diarrhea, pneumonia, malaria, and measles. Am J Clin Nutr. 2004 Jul;80(1):193–8. PubMed Caulfield LE, de Onis M, Blossner M, Black RE. Undernutrition as an underlying cause of child deaths associated with diarrhea, pneumonia, malaria, and measles. Am J Clin Nutr. 2004 Jul;80(1):193–8. PubMed
7.
Zurück zum Zitat Wahn V, Ehl S, Niehues T. Infektanfälligkeit — versuch einer definition. Allergologie. 2003;26(10). Wahn V, Ehl S, Niehues T. Infektanfälligkeit — versuch einer definition. Allergologie. 2003;26(10).
8.
Zurück zum Zitat International Union of Immunological Societies Expert Committee on Primary Immunodeficiencies, Notarangelo LD, Fischer A, Geha RS, Casanova JL, Chapel H, et al. Primary immunodeficiencies: 2009 update. J Allergy Clin Immunol. 2009 Dec;124(6):1161–78. PubMedCentralPubMedCrossRef International Union of Immunological Societies Expert Committee on Primary Immunodeficiencies, Notarangelo LD, Fischer A, Geha RS, Casanova JL, Chapel H, et al. Primary immunodeficiencies: 2009 update. J Allergy Clin Immunol. 2009 Dec;124(6):1161–78. PubMedCentralPubMedCrossRef
9.
Zurück zum Zitat Baumann U, Belohradsky BH, Friedrich W, Linde R, Niehues T, Renner E, et al. Primäre Immundefekte — Warnzeichen und Algorithmen zur Diagnosefindung. 1. ed. Bremen: UNI-MED SCIENCE; 2010. Baumann U, Belohradsky BH, Friedrich W, Linde R, Niehues T, Renner E, et al. Primäre Immundefekte — Warnzeichen und Algorithmen zur Diagnosefindung. 1. ed. Bremen: UNI-MED SCIENCE; 2010.
10.
Zurück zum Zitat Farmand S, Baumann U, von Bernuth H, Borte M, Foerster-Waldl E, et al. Interdisciplinary AWMF guideline for the diagnostics of primary immunodeficiency. Klin Padiatr. 2011 Nov;223(6):378–85. PubMedCrossRef Farmand S, Baumann U, von Bernuth H, Borte M, Foerster-Waldl E, et al. Interdisciplinary AWMF guideline for the diagnostics of primary immunodeficiency. Klin Padiatr. 2011 Nov;223(6):378–85. PubMedCrossRef
11.
Zurück zum Zitat Abel L, Plancoulaine S, Jouanguy E, Zhang SY, Mahfoufi N, Nicolas N, et al. Age-dependent mendelian predisposition to herpes simplex virus type 1 encephalitis in childhood. J Pediatr. 2010 Oct;157(4):623,9, 629.e1. PubMedCrossRef Abel L, Plancoulaine S, Jouanguy E, Zhang SY, Mahfoufi N, Nicolas N, et al. Age-dependent mendelian predisposition to herpes simplex virus type 1 encephalitis in childhood. J Pediatr. 2010 Oct;157(4):623,9, 629.e1. PubMedCrossRef
12.
Zurück zum Zitat Fieschi C, Casanova JL. The role of interleukin-12 in human infectious diseases: Only a faint signature. Eur J Immunol. 2003 Jun;33(6):1461–4. PubMedCrossRef Fieschi C, Casanova JL. The role of interleukin-12 in human infectious diseases: Only a faint signature. Eur J Immunol. 2003 Jun;33(6):1461–4. PubMedCrossRef
13.
Zurück zum Zitat Bakare N, Menschik D, Tiernan R, Hua W, Martin D. Severe combined immunodeficiency (SCID) and rotavirus vaccination: Reports to the vaccine adverse events reporting system (VAERS). Vaccine. 2010 Sep 14;28(40):6609–12. PubMedCrossRef Bakare N, Menschik D, Tiernan R, Hua W, Martin D. Severe combined immunodeficiency (SCID) and rotavirus vaccination: Reports to the vaccine adverse events reporting system (VAERS). Vaccine. 2010 Sep 14;28(40):6609–12. PubMedCrossRef
14.
Zurück zum Zitat Wolska-Kusnierz B, Bajer A, Caccio S, Heropolitanska-Pliszka E, Bernatowska E, Socha P, et al. Cryptosporidium infection in patients with primary immunodeficiencies. J Pediatr Gastroenterol Nutr. 2007 Oct;45(4):458–64. PubMedCrossRef Wolska-Kusnierz B, Bajer A, Caccio S, Heropolitanska-Pliszka E, Bernatowska E, Socha P, et al. Cryptosporidium infection in patients with primary immunodeficiencies. J Pediatr Gastroenterol Nutr. 2007 Oct;45(4):458–64. PubMedCrossRef
15.
Zurück zum Zitat Plebani A, Soresina A, Rondelli R, Amato GM, Azzari C, Cardinale F, et al. Clinical, immunological, and molecular analysis in a large cohort of patients with X-linked agammaglobulinemia: An italian multicenter study. Clin Immunol. 2002 9;104(3):221–30. PubMedCrossRef Plebani A, Soresina A, Rondelli R, Amato GM, Azzari C, Cardinale F, et al. Clinical, immunological, and molecular analysis in a large cohort of patients with X-linked agammaglobulinemia: An italian multicenter study. Clin Immunol. 2002 9;104(3):221–30. PubMedCrossRef
16.
Zurück zum Zitat Quinti I, Soresina A, Spadaro G, Martino S, Donnanno S, Agostini C, et al. Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency. J Clin Immunol. 2007 May;27(3):308–16. PubMedCrossRef Quinti I, Soresina A, Spadaro G, Martino S, Donnanno S, Agostini C, et al. Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency. J Clin Immunol. 2007 May;27(3):308–16. PubMedCrossRef
17.
Zurück zum Zitat Schimke LF, Sawalle-Belohradsky J, Roesler J, Wollenberg A, Rack A, Borte M, et al. Diagnostic approach to the hyper-IgE syndromes: Immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis. J Allergy Clin Immunol. 2010 Sep;126(3):611,7.e1. PubMedCrossRef Schimke LF, Sawalle-Belohradsky J, Roesler J, Wollenberg A, Rack A, Borte M, et al. Diagnostic approach to the hyper-IgE syndromes: Immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis. J Allergy Clin Immunol. 2010 Sep;126(3):611,7.e1. PubMedCrossRef
18.
Zurück zum Zitat van den Berg JM, van Koppen E, Ahlin A, Belohradsky BH, Bernatowska E, Corbeel L, et al. Chronic granulomatous disease: The european experience. PLoS One. 2009;4(4):e5234. PubMedCentralPubMedCrossRef van den Berg JM, van Koppen E, Ahlin A, Belohradsky BH, Bernatowska E, Corbeel L, et al. Chronic granulomatous disease: The european experience. PLoS One. 2009;4(4):e5234. PubMedCentralPubMedCrossRef
19.
Zurück zum Zitat Yarmohammadi H, Estrella L, Doucette J, Cunningham-Rundles C. Recognizing primary immune deficiency in clinical practice. Clin Vaccine Immunol. 2006 Mar;13(3):329–32. PubMedCentralPubMedCrossRef Yarmohammadi H, Estrella L, Doucette J, Cunningham-Rundles C. Recognizing primary immune deficiency in clinical practice. Clin Vaccine Immunol. 2006 Mar;13(3):329–32. PubMedCentralPubMedCrossRef
20.
Zurück zum Zitat Gruber C, Keil T, Kulig M, Roll S, Wahn U, Wahn V, et al. History of respiratory infections in the first 12 yr among children from a birth cohort Pediatr Allergy Immunol. 2008 Sep;19(6):505–12. PubMedCrossRef Gruber C, Keil T, Kulig M, Roll S, Wahn U, Wahn V, et al. History of respiratory infections in the first 12 yr among children from a birth cohort Pediatr Allergy Immunol. 2008 Sep;19(6):505–12. PubMedCrossRef
21.
Zurück zum Zitat Okkes IM, Polderman GO, Fryer GE, Yamada T, Bujak M, Oskam SK, et al. The role of family practice in different health care systems: A comparison of reasons for encounter, diagnoses, and interventions in primary care populations in the netherlands, japan, poland, and the united states. J Fam Pract. 2002 Jan;51(1):72–3. PubMed Okkes IM, Polderman GO, Fryer GE, Yamada T, Bujak M, Oskam SK, et al. The role of family practice in different health care systems: A comparison of reasons for encounter, diagnoses, and interventions in primary care populations in the netherlands, japan, poland, and the united states. J Fam Pract. 2002 Jan;51(1):72–3. PubMed
Metadaten
Titel
Physiologische Infektanfälligkeit oder Immundefekt?
Ungewöhnliche Infektionen
verfasst von
Prof. Dr. med. Ulrich Baumann
Publikationsdatum
02.09.2014
Verlag
Urban & Vogel
Erschienen in
Pädiatrie / Ausgabe Sonderheft 1/2014
Print ISSN: 1867-2132
Elektronische ISSN: 2196-6443
DOI
https://doi.org/10.1007/s15014-014-0462-9

Weitere Artikel der Sonderheft 1/2014

Pädiatrie 1/2014 Zur Ausgabe

Neu im Fachgebiet Pädiatrie

Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Pädiatrie und bleiben Sie gut informiert – ganz bequem per eMail.