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Cancer and Metastasis Reviews

Erschienen in:

28.11.2016

PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment

verfasst von: Angel Guerrero-Zotano, Ingrid A. Mayer, Carlos L. Arteaga

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 4/2016

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Abstract

Anti-cancer cancer-targeted therapies are designed to exploit a particular vulnerability in the tumor, which in most cases results from its dependence on an oncogene and/or loss of a tumor suppressor. Mutations in the phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway are freqcuently found in breast cancers and associated with cellular transformation, tumorigenesis, cancer progression, and drug resistance. Several drugs targeting PI3K/ATK/mTOR are currently in clinical trials, mainly in combination with endocrine therapy and anti-HER2 therapy. These drugs are the focus of this review.

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Titel: PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment
verfasst von: Angel Guerrero-Zotano
Ingrid A. Mayer
Carlos L. Arteaga
Publikationsdatum: 28.11.2016
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 4/2016
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-016-9637-x

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PI3K/AKT/mTOR: role in breast cancer progression, drug resistance, and treatment

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Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie