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30.03.2017 | Original Article

Polymorphisms of xeroderma pigmentosum genes (XPC, XPD, and XPG) and susceptibility to acute leukemia among a sample of Egyptian patients

verfasst von: Iman Rifaat ElMahgoub, Heba Mahmoud Gouda, Mohamed Abdelmooti Samra, Iman AbdelMohsen Shaheen, Aya Hassan ElMaraashly

Erschienen in: Journal of Hematopathology | Ausgabe 1/2017

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Abstract

DNA repair systems play a key role in protecting the DNA from damage caused by different endogenous and environmental factors. Genetic polymorphisms in DNA repair genes may lead to increased cancer susceptibility including leukemia. Due to different environmental genetic interactions among each population, the aim of the current study was to assess the association between three genetic polymorphisms of xeroderma pigmentosum complementation group: XPD (rs13181), XPC (rs2228001), and XPG (rs17655) and the susceptibility to acute leukemia in Egypt. The present study included 50 patients with acute leukemia, in addition to 100 normal volunteers as control group. Genotyping for the genes was done by PCR-RFLP technique. The study revealed that patients homovariant for XPD had fourfold increased risk of developing AML (OR = 4.4, P = 0.025) either alone or with variant genotypes of XPC and XPG. No statistically significant association was found between neither individual nor combined polymorphisms and disease risk of ALL in this study. Determination of XPD polymorphism could be considered as molecular markers associated with susceptibility to develop AML.

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Titel: Polymorphisms of xeroderma pigmentosum genes (XPC, XPD, and XPG) and susceptibility to acute leukemia among a sample of Egyptian patients
verfasst von: Iman Rifaat ElMahgoub
Heba Mahmoud Gouda
Mohamed Abdelmooti Samra
Iman AbdelMohsen Shaheen
Aya Hassan ElMaraashly
Publikationsdatum: 30.03.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Hematopathology / Ausgabe 1/2017
Print ISSN: 1868-9256
Elektronische ISSN: 1865-5785
DOI: https://doi.org/10.1007/s12308-017-0290-2

Springer Medizin

Polymorphisms of xeroderma pigmentosum genes (XPC, XPD, and XPG) and susceptibility to acute leukemia among a sample of Egyptian patients

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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