nach oben

European Journal of Nutrition

Erschienen in:

19.11.2019 | Original Contribution

Population biomonitoring of micronutrient intakes in children using urinary spot samples

verfasst von: Magali Rios-Leyvraz, Murielle Bochud, Clara Benzi Schmid, Max Haldimann, Pascal Bovet, Arnaud Chiolero

Erschienen in: European Journal of Nutrition | Ausgabe 7/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Urinary spot samples are a promising method for the biomonitoring of micronutrient intake in children. Our aim was to assess whether urinary spot samples could be used to estimate the 24-h urinary excretion of potassium, phosphate, and iodine at the population level.

Methods

A cross-sectional study of 101 children between 6 and 16 years of age was conducted. Each child collected a 24-h urine collection and three urinary spot samples (evening, overnight, and morning). Several equations were used to estimate 24-h excretion based on the urinary concentrations of each micronutrient in the three spot samples. Various equations and spot combinations were compared using several statistics and plots.

Results

Ninety-four children were included in the analysis (mean age: 10.5 years). The mean measured 24-h urinary excretions of potassium, phosphate, and iodine were 1.76 g, 0.61 g, and 95 µg, respectively. For potassium, the best 24-h estimates were obtained with the Mage equation and morning spot (mean bias: 0.2 g, correlation: 0.27, precision: 56%, and misclassification: 10%). For phosphate, the best 24-h estimates were obtained with the Mage equation and overnight spot (mean bias: − 0.03 g, correlation: 0.54, precision: 72%, and misclassification: 10%). For iodine, the best 24-h estimates were obtained with the Remer equation and overnight spot (mean bias: − 8 µg, correlation: 0.58, precision: 86%, misclassification: 16%).

Conclusions

Urinary spot samples could be a good alternative to 24-h urine collection for the population biomonitoring of iodine and phosphate intakes in children. For potassium, spot samples were less reliable.

Nur mit Berechtigung zugänglich

Tulchinsky TH (2010) Micronutrient deficiency conditions: global health issues. Public Health Rev 32:243–255CrossRef

Shim J-S, Oh K, Kim HC (2014) Dietary assessment methods in epidemiologic studies. Epidemiol Health 36:e2014009CrossRef

Dragsted LO, Gao Q, Scalbert A et al (2018) Validation of biomarkers of food intake-critical assessment of candidate biomarkers. Genes Nutr 13:14. https://doi.org/10.1186/s12263-018-0603-9CrossRefPubMedPubMedCentral

de Vries J, Antoine JM, Burzykowski T et al (2013) Markers for nutrition studies: review of criteria for the evaluation of markers. Eur J Nutr 52:1685–1699. https://doi.org/10.1007/s00394-013-0553-3CrossRefPubMed

Huang L, Crino M, Wu JH et al (2016) Mean population salt intake estimated from 24-h urine samples and spot urine samples: a systematic review and meta-analysis. Int J Epidemiol 45:239–250. https://doi.org/10.1093/ije/dyv313CrossRefPubMed

Cogswell ME, Wang CY, Chen TC et al (2013) Validity of predictive equations for 24-h urinary sodium excretion in adults aged 18–39 y. Am J Clin Nutr 98:1502–1513. https://doi.org/10.3945/ajcn.113.059436CrossRefPubMedPubMedCentral

Mente A, O’Donnell MJ, Dagenais G et al (2014) Validation and comparison of three formulae to estimate sodium and potassium excretion from a single morning fasting urine compared to 24-h measures in 11 countries. J Hypertens 32:1005–1014. https://doi.org/10.1097/HJH.0000000000000122CrossRefPubMed

Rios-Leyvraz M, Bovet P, Tabin R et al (2018) Urine spot samples can be used to estimate 24-hour urinary sodium excretion in children. J Nutr 148:1946–1953. https://doi.org/10.1093/jn/nxy211CrossRefPubMed

Dong J, Yan Y, Fan H et al (2019) Accuracy validation of 8 equations to estimate 24-hour sodium by spot urine in young adolescents. Am J Hypertens 32:257–264CrossRef

10.

Polonia J, Lobo MF, Martins L et al (2017) Estimation of populational 24-h urinary sodium and potassium excretion from spot urine samples: evaluation of four formulas in a large national representative population. J Hypertens 35:477–486. https://doi.org/10.1097/HJH.0000000000001180CrossRefPubMed

11.

Robinson-Cohen C, Ix JH, Smits G et al (2014) Estimation of 24-hour urine phosphate excretion from spot urine collection: development of a predictive equation. J Ren Nutr 24:194–199. https://doi.org/10.1053/j.jrn.2014.02.001CrossRefPubMed

12.

Montenegro-Bethancourt G, Johner SA, Stehle P et al (2015) Iodine status assessment in children: spot urine iodine concentration reasonably reflects true twenty-four-hour iodine excretion only when scaled to creatinine. Thyroid 25:688–697. https://doi.org/10.1089/thy.2015.0006CrossRefPubMed

13.

Rios-Leyvraz M, Bovet P, Bochud M et al (2018) Estimation of salt intake and excretion in children in one region of Switzerland: a cross-sectional study. Eur J Nutr. https://doi.org/10.1007/s00394-018-1845-4CrossRefPubMed

14.

Haldimann M, Bochud M, Burnier M et al (2015) Prevalence of iodine inadequacy in Switzerland assessed by the estimated average requirement cut-point method in relation to the impact of iodized salt. Public Health Nutr 18:1333–1342. https://doi.org/10.1017/S1368980014002018CrossRefPubMed

15.

Remer T, Neubert A, Maser-Gluth C (2002) Anthropometry-based reference values for 24-h urinary creatinine excretion during growth and their use in endocrine and nutritional research. Am J Clin Nutr 75:561–569CrossRef

16.

Mage DT, Allen RH, Kodali A (2008) Creatinine corrections for estimating children’s and adult’s pesticide intake doses in equilibrium with urinary pesticide and creatinine concentrations. J Expo Sci Env Epidemiol 18:360–368. https://doi.org/10.1038/sj.jes.7500614CrossRef

17.

Kawasaki T, Itoh K, Uezono K, Sasaki H (1993) A simple method for estimating 24 h urinary sodium and potassium excretion from second morning voiding urine specimen in adults. Clin Exp Pharmacol Physiol 20:7–14CrossRef

18.

Kawasaki T, Uezono K, Itoh K, Ueno M (1991) Prediction of 24-hour urinary creatinine excretion from age, body weight and height of an individual and its application. Nihon Koshu Eisei Zasshi 38:567–574PubMed

19.

Zimmermann MB, Andersson M (2012) Assessment of iodine nutrition in populations: past, present, and future. Nutr Rev 70:553–570. https://doi.org/10.1111/j.1753-4887.2012.00528.xCrossRefPubMed

20.

World Health Organization (2012) Guideline: Potassium intake for adults and children. World Health Organization (WHO), Geneva

21.

Taranta-Janusz K, Labieniec L, Porowski T et al (2017) Determining normal values of urinary phosphorus excretion in 3913 healthy children aged 2–18 to aid early diagnosis and treatment for urolithiasis. Acta Paediatr 106:1170–1175. https://doi.org/10.1111/apa.13856CrossRefPubMed

22.

Bland JM, Altman DG (1986) Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1:307–310CrossRef

23.

Bland JM, Altman DG (1999) Measuring agreement in method comparison studies. Stat Methods Med Res 8:135–160CrossRef

24.

Tasevska N, Runswick SA, Bingham SA (2006) Urinary potassium is as reliable as urinary nitrogen for use as a recovery biomarker in dietary studies of free living individuals. J Nutr 136:1334–1340CrossRef

25.

Morimoto Y, Sakuma M, Ohta H et al (2014) Estimate of dietary phosphorus intake using 24-h urine collection. J Clin Biochem Nutr 55:62–66. https://doi.org/10.3164/jcbn.14-15CrossRefPubMedPubMedCentral

26.

Wang CY, Cogswell ME, Loria CM et al (2013) Urinary excretion of sodium, potassium, and chloride, but not iodine, varies by timing of collection in a 24-hour calibration study. J Nutr 143:1276–1282. https://doi.org/10.3945/jn.113.175927CrossRefPubMedPubMedCentral

27.

Perrine CG, Cogswell ME, Swanson CA et al (2014) Comparison of population iodine estimates from 24-hour urine and timed-spot urine samples. Thyroid 24:748–757CrossRef

28.

König F, Andersson M, Hotz K et al (2011) Ten repeat collections for urinary iodine from spot samples or 24-hour samples are needed to reliably estimate individual iodine status in women. J Nutr 141:2049–2054CrossRef

29.

Umesawa M, Yamagishi K, Sawachi S et al (2010) Urea nitrogen concentrations in spot urine, estimated protein intake and blood pressure levels in a Japanese general population. Am J Hypertens 23:852–858. https://doi.org/10.1038/ajh.2010.54CrossRefPubMed

Titel: Population biomonitoring of micronutrient intakes in children using urinary spot samples
verfasst von: Magali Rios-Leyvraz
Murielle Bochud
Clara Benzi Schmid
Max Haldimann
Pascal Bovet
Arnaud Chiolero
Publikationsdatum: 19.11.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 7/2020
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-019-02144-9

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 7/2020

Skeletal muscle proteome of piglets is affected in a muscle-dependent manner by a limiting total sulfur amino acid supply

Correction to: Prebiotic effect of inulin‑type fructans on faecal microbiota and short‑chain fatty acids in type 2 diabetes: a randomised controlled trial

Effect of mushroom polysaccharides from Pleurotus eryngii on obesity and gut microbiota in mice fed a high-fat diet

Effects of vitamin C on oxidative stress, inflammation, muscle soreness, and strength following acute exercise: meta-analyses of randomized clinical trials

Modest improvement in CVD risk markers in older adults following quinoa (Chenopodium quinoa Willd.) consumption: a randomized-controlled crossover study with a novel food product