Can cognitive function be improved in HF?
The trajectory of cognitive impairment and possible decline in HF remains poorly understood. Despite being a known risk factor for degenerative disorders like Alzheimer’s disease and vascular dementia (e.g., [
75]), two recent studies found that cognitive function remains relatively stable over short time intervals in patients with mild HF ([
6,
78]). Moreover, there is research to suggest that the cognitive deficits of HF may be at least partly reversible. For example, a sample of 40 well-managed HF patients showed subtle improvements in cognitive function over a 12 month period, particularly in the areas of attention and executive function [
87]. Though the exact mechanisms for these cognitive gains are unclear, it appears most likely attributable to improved medical oversight for the study participants [
87]. Similarly, other studies have shown improved cognitive function in persons with HF as a result of medical intervention, including cardiac transplantation [
17,
20,
43,
66] pacemaker and cardiac assist device implantation [
73,
108], and initiation of treatment with ACE inhibitors [
7,
109]. In each case, improved cardiac function was associated with better cognitive function after treatment. Taken together, these results suggest that cognitive impairment in HF may be at least partially reversible through improved cardiovascular function.
Can exercise improve cognitive function in HF?
Exercise interventions have been linked to improved neurocognitive outcomes across a wide range of patient and healthy samples [
29,
71]. Aerobic exercise is linked to greater gray and white matter volume [
30] and increased functional connectivity in the prefrontal cortex [
102]. The most consistent effects of aerobic exercise on cognition have been in executive functioning, although several investigations have found improvements in other domains such as attention, visuospatial functioning, processing speed [
3,
18,
36]. For example, Voss et al. [
101] demonstrated that one-year of exercise training was associated with improved working memory performance in healthy older adults. Even exercise at low intensities has been shown to improve attention [
45], memory [
81], and concentration [
89] in healthy older adults.
Mechanisms for cognitive improvement with exercise
Improvements in cognitive function with exercise are likely related to beneficial brain changes. For example, research has shown that increased cardiorespiratory fitness is associated with reduced brain atrophy [
29], the preservation of gray and white matter in the medial-temporal, parietal, and frontal brain regions ([
80]), and greater hippocampal volumes [
38]. Higher fitness levels have also shown positive effects on functional brain outcomes including greater activation in areas associated with attentional control [
31] and greater activity in the frontal and parietal lobes [
30]. Moderate- to high- intensity aerobic exercise has produced similar benefits including increases in gray and white matter volume [
30] and increased functional connectivity in the prefrontal cortex [
102].
Exercise may improve cognitive function in HF patients through other mechanisms. For example levels of C-reactive protein (CRP), normally an inflammatory cytokine associated with acute injury [
72], are inversely related to amount of physical activity ([
28]; [
25,
59]). Exercise is thought to reduce activation of the sympathetic nervous system, which in turn inhibits the release of inflammatory markers, including CRP [
28]. This hypothesis has some support in the literature with a heart failure population. Following 6 months of structured exercise, HF patients demonstrated significantly lower levels of CRP, than sedentary controls [
68]. The lower levels of CRP may also be related to cognitive function. Research suggests increased levels of CRP are related to impairments in the areas of executive function and memory [
50,
70,
93,
107].
Prior work has also identified various circulating biomarkers which may also influence cognitive function in HF. There is little work done on these markers in relation to cardiovascular fitness as most are either associated with eating behavior or newly discovered themselves (i.e. adiponectin). In light of these shortcomings, some research has been conducted examining the influence of physical exercise on biomarkers. Brain derived neurotrophic factor (BDNF) has demonstrated positive relationship with exercise [
42,
53]. This relationship has also been found in an HF population [
39], and is important as research indicates cognitive impairment is at least partially caused by decreased BDNF levels [
10]. Additionally, BDNF is important for brain health and cognitive function (e.g., [
12,
64]).
Leptin has also been connected to cognitive function [
62]. Specifically, leptin has been inversely related to level of cardiovascular fitness levels in both HF [
90] and non-HF populations [
21,
77]. Ghrelin, is a largely under researched hormone, thus, little evidence exists in relation to cardiovascular fitness. However, one study found ghrelin to have an inverse relationship with cardiovascular fitness [
86]. Finally, adiponectin has also been studied in relation to cardiovascular fitness as well. Improvements in cardiovascular fitness have been associated with reduced adiponectin levels [
11,
65].
In HF, improved cognitive performance with exercise may also be related to comorbid medical conditions. HF is associated with several cardiac and non-cardiac comorbidities; up to 40 % of HF patients have at least five non-cardiac medical conditions [
22]. The presence of these comorbid conditions in patients with HF is associated with decreased quality of life, poorer prognosis [
67], increased rates of hospitalization, and higher rates of mortality [
22]. Common comorbidities of HF include hypertension, type 2 diabetes mellitus, obstructive sleep apnea, chronic obstructive pulmonary disorder, and depression. Each of these conditions has been shown to have an independent association with cognitive deficits, either in HF or non-HF populations, and are likely add to or interact with cardiac dysfunction in HF [
49]. Exercise is a common non-pharmacological treatment for a number of comorbid conditions and has been shown to prevent the development or reduce the severity of such conditions both in HF and non-HF populations (e.g., [
9,
19,
23,
57,
69]).
Cerebral blood flow as a mechanism for cognitive improvement with exercise in heart failure
One key mechanism for cognitive gains with exercise which may be particularly important in HF patients is improved cerebral blood flow (CBF). Patients with HF show up to a 30 % reduction in global cerebral blood flow (CBF) [
43]. Typically, CBF reductions appear to be greatest in posterior cortical areas [
8] but have also been observed in other brain regions important for cognitive function including the frontal, temporal, and parietal lobes [
8,
24,
100]. Reduced CBF is also related to poorer cognitive function in HF. In one study, resting regional CBF in elderly patients with HF was compared to healthy age-matched controls using single-photon emission computed tomography (SPECT). Results of this study demonstrated that reduced CBF was common in patients with HF and associated with poorer global cognition, visual and verbal memory, learning, and language tests. Importantly, global cognition was significantly associated with CBF in the posterior cingulate cortex and precuneus [
8]. Another study found that global cognition, measured by performance on the Mini Mental Status Exam (MMSE), was significantly positively associated with CBF velocity of the right middle cerebral artery (MCA) in patients with HF [
51].
Increased CBF is associated with improved cognitive function in patients with HF
Intervention studies have shown that increased CBF is linked to improvements in cognitive function in HF. As above, many of the HF treatments that have been shown to improve cognitive function (e.g., cardiac transplantation, pacemaker implantation, ACE inhibitors) are also known to improve CBF [
27,
43,
66]. Several studies have shown that although CBF is reduced at baseline, they become normalized following cardiac transplantation representing an increase of up to 30 % [
27,
43,
66]. Similar effects have been observed following implantation of a pacemaker [
96]. Finally, in patients with severe HF, CBF improved by approximately 12 ml/100 g per minute following the initiation of treatment with an ACE inhibitor and normalized over time [
76]. Given that HF treatment such as cardiac transplantation, pacemaker implantation and ACE inhibitors have been shown to both improve cognitive function and increase CBF, it can be reasoned that increases in CBF may be an important mechanism for improved cognitive function in HF patients.
Evidence for cognitive improvement with exercise in HF
There has been some research to suggest that cognition can improve following exercise in HF. For example, Tanne et al. [
94] examined the benefits of twice weekly aerobic exercise at 60–70 % of maximal heart rate on cognitive function in HF patients. Results demonstrated that exercise was associated with improvements in attention/psychomotor speed and executive function. Unfortunately, these findings are limited by a small number of participants in the intervention (
n = 18) and control group (
n = 5) and potential baseline differences in cognitive function between these groups were not examined. Additionally, CBF was not measured.
Consistent with these possible benefits of exercise, two recent studies have examined the link between fitness levels and cognitive function in HF. One study found that greater metabolic equivalents (METs) from a standardized stress test was related to better performance on measures of attention (β = .41,
p = .03), executive function (β = .37,
p = .04), and memory (β = .46,
p = .04) even after controlling for important medical and demographic characteristics, [
40]. Similarly, another study examined the association between exercise capacity, estimated by distance walked on the 6-min walk test, and cognitive function in 80 elderly patients with HF. As above, results showed that greater exercise capacity was associated with better cognitive function [
13].