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Forensic Toxicology

Erschienen in:

06.09.2018 | Case Report

Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8

verfasst von: Yoshiaki Iwamuro, Takaya Murakami, Reiko Ishimaru, Satoshi Chinaka

Erschienen in: Forensic Toxicology | Ausgabe 1/2019

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Abstract

Purpose

This case report describes the purposeful forensic detection of both the muscle relaxant rocuronium and the reversal agent sugammadex in the blood of a patient who died 8 days after surgery.

Methods

The two compounds were analyzed by liquid chromatography/mass spectrometry (LC/MS).

Results

The molar concentrations of the two compounds were almost the same, indicating that rocuronium had lost its muscle relaxant effect, because rocuronium and sugammadex formed a 1:1 complex in the blood due to their high affinities.

Conclusions

When a muscle relaxant is detected in a forensic sample, the presence of its reversal agent should also be investigated.

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Titel: Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8
verfasst von: Yoshiaki Iwamuro
Takaya Murakami
Reiko Ishimaru
Satoshi Chinaka
Publikationsdatum: 06.09.2018
Verlag: Springer Japan
Erschienen in: Forensic Toxicology / Ausgabe 1/2019
Print ISSN: 1860-8965
Elektronische ISSN: 1860-8973
DOI: https://doi.org/10.1007/s11419-018-0441-x

Springer Medizin

Postmortem detection of rocuronium and sugammadex by LC/MS in the blood of a patient who died on postoperative day 8

Abstract

Purpose

Methods

Results

Conclusions

Neu im Fachgebiet Rechtsmedizin

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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