Skip to main content
Erschienen in: Journal of Gastrointestinal Surgery 10/2017

06.07.2017 | Review Article

Postoperative Abdominal Adhesions: Clinical Significance and Advances in Prevention and Management

verfasst von: Demetrios Moris, Jeffery Chakedis, Amir A. Rahnemai-Azar, Ana Wilson, Mairead Marion Hennessy, Antonios Athanasiou, Eliza W. Beal, Chrysoula Argyrou, Evangelos Felekouras, Timothy M. Pawlik

Erschienen in: Journal of Gastrointestinal Surgery | Ausgabe 10/2017

Einloggen, um Zugang zu erhalten

Abstract

Postoperative adhesions remain one of the more challenging issues in surgical practice. Although peritoneal adhesions occur after every abdominal operation, the density, time interval to develop symptoms, and clinical presentation are highly variable with no predictable patterns. Numerous studies have investigated the pathophysiology of postoperative adhesions both in vitro and in vivo. Factors such as type and location of adhesions, as well as timing and recurrence of adhesive obstruction remain unpredictable and poorly understood. Although the majority of postoperative adhesions are clinically silent, the consequences of adhesion formation can represent a lifelong problem including chronic abdominal pain, recurrent intestinal obstruction requiring multiple hospitalizations, and infertility. Moreover, adhesive disease can become a chronic medical condition with significant morbidity and no effective therapy. Despite recent advances in surgical techniques, there is no reliable strategy to manage postoperative adhesions. We herein review the pathophysiology and clinical significance of postoperative adhesions while highlighting current techniques of prevention and treatment.
Literatur
1.
Zurück zum Zitat Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL. Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Digestive surgery. 2001;18(4):260–73. doi:50149.PubMedCrossRef Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL. Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Digestive surgery. 2001;18(4):260–73. doi:50149.PubMedCrossRef
4.
Zurück zum Zitat Bruggmann D, Tchartchian G, Wallwiener M, Munstedt K, Tinneberg HR, Hackethal A. Intra-abdominal adhesions: definition, origin, significance in surgical practice, and treatment options. Deutsches Arzteblatt international. 2010;107(44):769–75. doi:10.3238/arztebl.2010.0769.PubMedPubMedCentral Bruggmann D, Tchartchian G, Wallwiener M, Munstedt K, Tinneberg HR, Hackethal A. Intra-abdominal adhesions: definition, origin, significance in surgical practice, and treatment options. Deutsches Arzteblatt international. 2010;107(44):769–75. doi:10.​3238/​arztebl.​2010.​0769.PubMedPubMedCentral
6.
Zurück zum Zitat Taylor GW, Jayne DG, Brown SR, Thorpe H, Brown JM, Dewberry SC et al. Adhesions and incisional hernias following laparoscopic versus open surgery for colorectal cancer in the CLASICC trial. The British journal of surgery. 2010;97(1):70–8. doi:10.1002/bjs.6742.PubMedCrossRef Taylor GW, Jayne DG, Brown SR, Thorpe H, Brown JM, Dewberry SC et al. Adhesions and incisional hernias following laparoscopic versus open surgery for colorectal cancer in the CLASICC trial. The British journal of surgery. 2010;97(1):70–8. doi:10.​1002/​bjs.​6742.PubMedCrossRef
10.
Zurück zum Zitat Cheong YC, Laird SM, Li TC, Shelton JB, Ledger WL, Cooke ID. Peritoneal healing and adhesion formation/reformation. Human reproduction update. 2001;7(6):556–66.PubMedCrossRef Cheong YC, Laird SM, Li TC, Shelton JB, Ledger WL, Cooke ID. Peritoneal healing and adhesion formation/reformation. Human reproduction update. 2001;7(6):556–66.PubMedCrossRef
12.
Zurück zum Zitat Ivarsson ML, Bergstrom M, Eriksson E, Risberg B, Holmdahl L. Tissue markers as predictors of postoperative adhesions. The British journal of surgery. 1998;85(11):1549–54.PubMedCrossRef Ivarsson ML, Bergstrom M, Eriksson E, Risberg B, Holmdahl L. Tissue markers as predictors of postoperative adhesions. The British journal of surgery. 1998;85(11):1549–54.PubMedCrossRef
14.
Zurück zum Zitat Norrman B, Wallen P, Ranby M. Fibrinolysis mediated by tissue plasminogen activator. Disclosure of a kinetic transition. European journal of biochemistry. 1985;149(1):193–200.PubMedCrossRef Norrman B, Wallen P, Ranby M. Fibrinolysis mediated by tissue plasminogen activator. Disclosure of a kinetic transition. European journal of biochemistry. 1985;149(1):193–200.PubMedCrossRef
15.
Zurück zum Zitat Holmdahl L, Eriksson E, Al-Jabreen M, Risberg B. Fibrinolysis in human peritoneum during operation. Surgery. 1996;119(6):701–5.PubMedCrossRef Holmdahl L, Eriksson E, Al-Jabreen M, Risberg B. Fibrinolysis in human peritoneum during operation. Surgery. 1996;119(6):701–5.PubMedCrossRef
16.
Zurück zum Zitat Lu HR, Wu Z, Pauwels P, Lijnen HR, Collen D. Comparative thrombolytic properties of tissue-type plasminogen activator (t-PA), single-chain urokinase-type plasminogen activator (u-PA) and K1K2Pu (a t-PA/u-PA chimera) in a combined arterial and venous thrombosis model in the dog. Journal of the American College of Cardiology. 1992;19(6):1350–9.PubMedCrossRef Lu HR, Wu Z, Pauwels P, Lijnen HR, Collen D. Comparative thrombolytic properties of tissue-type plasminogen activator (t-PA), single-chain urokinase-type plasminogen activator (u-PA) and K1K2Pu (a t-PA/u-PA chimera) in a combined arterial and venous thrombosis model in the dog. Journal of the American College of Cardiology. 1992;19(6):1350–9.PubMedCrossRef
18.
Zurück zum Zitat Andreasen PA, Georg B, Lund LR, Riccio A, Stacey SN. Plasminogen activator inhibitors: hormonally regulated serpins. Molecular and cellular endocrinology. 1990;68(1):1–19.PubMedCrossRef Andreasen PA, Georg B, Lund LR, Riccio A, Stacey SN. Plasminogen activator inhibitors: hormonally regulated serpins. Molecular and cellular endocrinology. 1990;68(1):1–19.PubMedCrossRef
19.
20.
Zurück zum Zitat Rout UK, Diamond MP. Role of plasminogen activators during healing after uterine serosal lesioning in the rat. Fertility and sterility. 2003;79(1):138–45.PubMedCrossRef Rout UK, Diamond MP. Role of plasminogen activators during healing after uterine serosal lesioning in the rat. Fertility and sterility. 2003;79(1):138–45.PubMedCrossRef
21.
Zurück zum Zitat Holmdahl L, Ivarsson ML. The role of cytokines, coagulation, and fibrinolysis in peritoneal tissue repair. The European journal of surgery = Acta chirurgica. 1999;165(11):1012–9. doi:10.1080/110241599750007810.PubMed Holmdahl L, Ivarsson ML. The role of cytokines, coagulation, and fibrinolysis in peritoneal tissue repair. The European journal of surgery = Acta chirurgica. 1999;165(11):1012–9. doi:10.​1080/​1102415997500078​10.PubMed
22.
Zurück zum Zitat ten Broek RP, Schreinemacher MH, Jilesen AP, Bouvy N, Bleichrodt RP, van Goor H. Enterotomy risk in abdominal wall repair: a prospective study. Ann Surg. 2012;256(2):280–7.PubMedCrossRef ten Broek RP, Schreinemacher MH, Jilesen AP, Bouvy N, Bleichrodt RP, van Goor H. Enterotomy risk in abdominal wall repair: a prospective study. Ann Surg. 2012;256(2):280–7.PubMedCrossRef
24.
Zurück zum Zitat Van Der Krabben AA, Dijkstra FR, Nieuwenhuijzen M, Reijnen MM, Schaapveld M, Van Goor H. Morbidity and mortality of inadvertent enterotomy during adhesiotomy. Br J Surg. 2000;87(4):467–71.CrossRef Van Der Krabben AA, Dijkstra FR, Nieuwenhuijzen M, Reijnen MM, Schaapveld M, Van Goor H. Morbidity and mortality of inadvertent enterotomy during adhesiotomy. Br J Surg. 2000;87(4):467–71.CrossRef
25.
Zurück zum Zitat Ellis H. The clinical significance of adhesions: focus on intestinal obstruction. The European journal of surgery Supplement : = Acta chirurgica Supplement. 1997 (577):5–9. Ellis H. The clinical significance of adhesions: focus on intestinal obstruction. The European journal of surgery Supplement : = Acta chirurgica Supplement. 1997 (577):5–9.
26.
Zurück zum Zitat Ellis H. The clinical significance of adhesions: focus on intestinal obstruction. Eur J Surg Suppl. 1997;577:5–9. Ellis H. The clinical significance of adhesions: focus on intestinal obstruction. Eur J Surg Suppl. 1997;577:5–9.
27.
Zurück zum Zitat Lower AM, Hawthorn RJ, Clark D, Boyd JH, Finlayson AR, Knight AD et al. Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients. Human reproduction. 2004;19(8):1877–85. doi:10.1093/humrep/deh321.PubMedCrossRef Lower AM, Hawthorn RJ, Clark D, Boyd JH, Finlayson AR, Knight AD et al. Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients. Human reproduction. 2004;19(8):1877–85. doi:10.​1093/​humrep/​deh321.PubMedCrossRef
28.
Zurück zum Zitat Parker MC, Ellis H, Moran BJ, Thompson JN, Wilson MS, Menzies D et al. Postoperative adhesions: ten-year follow-up of 12,584 patients undergoing lower abdominal surgery. Diseases of the colon and rectum. 2001;44(6):822–29; discussion 9-30.PubMedCrossRef Parker MC, Ellis H, Moran BJ, Thompson JN, Wilson MS, Menzies D et al. Postoperative adhesions: ten-year follow-up of 12,584 patients undergoing lower abdominal surgery. Diseases of the colon and rectum. 2001;44(6):822–29; discussion 9-30.PubMedCrossRef
29.
Zurück zum Zitat Parker MC, Wilson MS, Menzies D, Sunderland G, Clark DN, Knight AD et al. The SCAR-3 study: 5-year adhesion-related readmission risk following lower abdominal surgical procedures. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 2005;7(6):551–8. doi:10.1111/j.1463-1318.2005.00857.x.CrossRef Parker MC, Wilson MS, Menzies D, Sunderland G, Clark DN, Knight AD et al. The SCAR-3 study: 5-year adhesion-related readmission risk following lower abdominal surgical procedures. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 2005;7(6):551–8. doi:10.​1111/​j.​1463-1318.​2005.​00857.​x.CrossRef
32.
33.
Zurück zum Zitat Sisodia V, Sahu SK, Kumar S. Clinical Profile of Patients with Postoperative Adhesive Intestinal Obstruction and its Association with Intraoperative Peritoneal Adhesion Index. Chirurgia. 2016;111(3):251–8.PubMed Sisodia V, Sahu SK, Kumar S. Clinical Profile of Patients with Postoperative Adhesive Intestinal Obstruction and its Association with Intraoperative Peritoneal Adhesion Index. Chirurgia. 2016;111(3):251–8.PubMed
34.
Zurück zum Zitat Ray NF, Larsen JW, Jr., Stillman RJ, Jacobs RJ. Economic impact of hospitalizations for lower abdominal adhesiolysis in the United States in 1988. Surgery, gynecology & obstetrics. 1993;176(3):271–6. Ray NF, Larsen JW, Jr., Stillman RJ, Jacobs RJ. Economic impact of hospitalizations for lower abdominal adhesiolysis in the United States in 1988. Surgery, gynecology & obstetrics. 1993;176(3):271–6.
35.
Zurück zum Zitat Ray NF, Denton WG, Thamer M, Henderson SC, Perry S. Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994. Journal of the American College of Surgeons. 1998;186(1):1–9.PubMedCrossRef Ray NF, Denton WG, Thamer M, Henderson SC, Perry S. Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994. Journal of the American College of Surgeons. 1998;186(1):1–9.PubMedCrossRef
36.
Zurück zum Zitat Coleman MG, McLain AD, Moran BJ. Impact of previous surgery on time taken for incision and division of adhesions during laparotomy. Diseases of the colon and rectum. 2000;43(9):1297–9.PubMedCrossRef Coleman MG, McLain AD, Moran BJ. Impact of previous surgery on time taken for incision and division of adhesions during laparotomy. Diseases of the colon and rectum. 2000;43(9):1297–9.PubMedCrossRef
37.
Zurück zum Zitat Beck DE, Ferguson MA, Opelka FG, Fleshman JW, Gervaz P, Wexner SD. Effect of previous surgery on abdominal opening time. Diseases of the colon and rectum. 2000;43(12):1749–53.PubMedCrossRef Beck DE, Ferguson MA, Opelka FG, Fleshman JW, Gervaz P, Wexner SD. Effect of previous surgery on abdominal opening time. Diseases of the colon and rectum. 2000;43(12):1749–53.PubMedCrossRef
39.
Zurück zum Zitat Ten Broek RP, Kok-Krant N, Bakkum EA, Bleichrodt RP, van Goor H. Different surgical techniques to reduce post-operative adhesion formation: a systematic review and meta-analysis. Human reproduction update. 2013;19(1):12–25. doi:10.1093/humupd/dms032.PubMedCrossRef Ten Broek RP, Kok-Krant N, Bakkum EA, Bleichrodt RP, van Goor H. Different surgical techniques to reduce post-operative adhesion formation: a systematic review and meta-analysis. Human reproduction update. 2013;19(1):12–25. doi:10.​1093/​humupd/​dms032.PubMedCrossRef
40.
Zurück zum Zitat Burns EM, Currie A, Bottle A, Aylin P, Darzi A, Faiz O. Minimal-access colorectal surgery is associated with fewer adhesion-related admissions than open surgery. The British journal of surgery. 2013;100(1):152–9. doi:10.1002/bjs.8964.PubMedCrossRef Burns EM, Currie A, Bottle A, Aylin P, Darzi A, Faiz O. Minimal-access colorectal surgery is associated with fewer adhesion-related admissions than open surgery. The British journal of surgery. 2013;100(1):152–9. doi:10.​1002/​bjs.​8964.PubMedCrossRef
41.
Zurück zum Zitat Lyell DJ, Caughey AB, Hu E, Blumenfeld Y, El-Sayed YY, Daniels K. Rectus muscle and visceral peritoneum closure at cesarean delivery and intraabdominal adhesions. American journal of obstetrics and gynecology. 2012;206(6):515 e1–5. doi:10.1016/j.ajog.2012.02.033.CrossRef Lyell DJ, Caughey AB, Hu E, Blumenfeld Y, El-Sayed YY, Daniels K. Rectus muscle and visceral peritoneum closure at cesarean delivery and intraabdominal adhesions. American journal of obstetrics and gynecology. 2012;206(6):515 e1–5. doi:10.​1016/​j.​ajog.​2012.​02.​033.CrossRef
42.
Zurück zum Zitat Liakakos T, Thomakos N, Fine PM, Dervenis C and Young RL ( 2001 ) Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg 18, 260–273.PubMedCrossRef Liakakos T, Thomakos N, Fine PM, Dervenis C and Young RL ( 2001 ) Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg 18, 260–273.PubMedCrossRef
43.
Zurück zum Zitat Lower AM, Hawthorn RJ, Clark D, Boyd JH, Finlayson AR, Knight AD, Crowe AM; Surgical and Clinical Research (SCAR) Group. Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients. Hum Reprod. 2004;19(8):1877–85.PubMedCrossRef Lower AM, Hawthorn RJ, Clark D, Boyd JH, Finlayson AR, Knight AD, Crowe AM; Surgical and Clinical Research (SCAR) Group. Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients. Hum Reprod. 2004;19(8):1877–85.PubMedCrossRef
44.
Zurück zum Zitat Corona R, Verguts J, Koninckx R, Mailova K, Binda MM, Koninckx PR. Intraperitoneal temperature and desiccation during endoscopic surgery. Intraoperative humidification and cooling of the peritoneal cavity can reduce adhesions. American journal of obstetrics and gynecology. 2011;205(4):392 e1–7. doi:10.1016/j.ajog.2011.06.091.CrossRef Corona R, Verguts J, Koninckx R, Mailova K, Binda MM, Koninckx PR. Intraperitoneal temperature and desiccation during endoscopic surgery. Intraoperative humidification and cooling of the peritoneal cavity can reduce adhesions. American journal of obstetrics and gynecology. 2011;205(4):392 e1–7. doi:10.​1016/​j.​ajog.​2011.​06.​091.CrossRef
45.
Zurück zum Zitat O'Leary DP, Coakley JB. The influence of suturing and sepsis on the development of postoperative peritoneal adhesions. Annals of the Royal College of Surgeons of England. 1992;74(2):134–7.PubMedPubMedCentral O'Leary DP, Coakley JB. The influence of suturing and sepsis on the development of postoperative peritoneal adhesions. Annals of the Royal College of Surgeons of England. 1992;74(2):134–7.PubMedPubMedCentral
46.
Zurück zum Zitat Elkins TE, Stovall TG, Warren J, Ling FW, Meyer NL. A histologic evaluation of peritoneal injury and repair: implications for adhesion formation. Obstetrics and gynecology. 1987;70(2):225–8.PubMed Elkins TE, Stovall TG, Warren J, Ling FW, Meyer NL. A histologic evaluation of peritoneal injury and repair: implications for adhesion formation. Obstetrics and gynecology. 1987;70(2):225–8.PubMed
47.
Zurück zum Zitat Schreinemacher MH, van Barneveld KW, Peeters E, Miserez M, Gijbels MJ, Greve JW et al. Adhesions to sutures, tackers, and glue for intraperitoneal mesh fixation: an experimental study. Hernia : the journal of hernias and abdominal wall surgery. 2014;18(6):865–72. doi:10.1007/s10029-013-1192-6.CrossRef Schreinemacher MH, van Barneveld KW, Peeters E, Miserez M, Gijbels MJ, Greve JW et al. Adhesions to sutures, tackers, and glue for intraperitoneal mesh fixation: an experimental study. Hernia : the journal of hernias and abdominal wall surgery. 2014;18(6):865–72. doi:10.​1007/​s10029-013-1192-6.CrossRef
48.
Zurück zum Zitat Ishikawa K, Sadahiro S, Tanaka Y, Suzuki T, Kamijo A, Tazume S. Optimal sutures for use in the abdomen: an evaluation based on the formation of adhesions and abscesses. Surgery today. 2013;43(4):412–7. doi:10.1007/s00595-012-0249-y.PubMedCrossRef Ishikawa K, Sadahiro S, Tanaka Y, Suzuki T, Kamijo A, Tazume S. Optimal sutures for use in the abdomen: an evaluation based on the formation of adhesions and abscesses. Surgery today. 2013;43(4):412–7. doi:10.​1007/​s00595-012-0249-y.PubMedCrossRef
50.
Zurück zum Zitat Blumenthal-Barby JS, Kostick KM, Delgado ED, Volk RJ, Kaplan HM, Wilhelms LA et al. Assessment of patients’ and caregivers’ informational and decisional needs for left ventricular assist device placement: Implications for informed consent and shared decision-making. Journal of Heart and Lung Transplantation. 2015;34(9):1182–9. doi:10.1016/j.healun.2015.03.026.PubMedPubMedCentralCrossRef Blumenthal-Barby JS, Kostick KM, Delgado ED, Volk RJ, Kaplan HM, Wilhelms LA et al. Assessment of patients’ and caregivers’ informational and decisional needs for left ventricular assist device placement: Implications for informed consent and shared decision-making. Journal of Heart and Lung Transplantation. 2015;34(9):1182–9. doi:10.​1016/​j.​healun.​2015.​03.​026.PubMedPubMedCentralCrossRef
51.
Zurück zum Zitat Deeken CR, Faucher KM, Matthews BD. A review of the composition, characteristics, and effectiveness of barrier mesh prostheses utilized for laparoscopic ventral hernia repair. Surgical endoscopy. 2012;26(2):566–75. doi:10.1007/s00464-011-1899-3.PubMedCrossRef Deeken CR, Faucher KM, Matthews BD. A review of the composition, characteristics, and effectiveness of barrier mesh prostheses utilized for laparoscopic ventral hernia repair. Surgical endoscopy. 2012;26(2):566–75. doi:10.​1007/​s00464-011-1899-3.PubMedCrossRef
52.
Zurück zum Zitat Gonzalez R, Rodeheaver GT, Moody DL, Foresman PA, Ramshaw BJ. Resistance to adhesion formation: a comparative study of treated and untreated mesh products placed in the abdominal cavity. Hernia : the journal of hernias and abdominal wall surgery. 2004;8(3):213–9. doi:10.1007/s10029-004-0213-x.CrossRef Gonzalez R, Rodeheaver GT, Moody DL, Foresman PA, Ramshaw BJ. Resistance to adhesion formation: a comparative study of treated and untreated mesh products placed in the abdominal cavity. Hernia : the journal of hernias and abdominal wall surgery. 2004;8(3):213–9. doi:10.​1007/​s10029-004-0213-x.CrossRef
53.
Zurück zum Zitat Smolarek S, Shalaby M, Paolo Angelucci G, Missori G, Capuano I, Franceschilli L et al. Small-Bowel Obstruction Secondary to Adhesions After Open or Laparoscopic Colorectal Surgery. JSLS : Journal of the Society of Laparoendoscopic Surgeons. 2016;20(4):e2016.00073. doi:10.4293/JSLS.2016.00073.PubMedPubMedCentralCrossRef Smolarek S, Shalaby M, Paolo Angelucci G, Missori G, Capuano I, Franceschilli L et al. Small-Bowel Obstruction Secondary to Adhesions After Open or Laparoscopic Colorectal Surgery. JSLS : Journal of the Society of Laparoendoscopic Surgeons. 2016;20(4):e2016.00073. doi:10.​4293/​JSLS.​2016.​00073.PubMedPubMedCentralCrossRef
54.
Zurück zum Zitat Takase-Sanchez MM, Brooks HM, Hale DS, Heit MH. Obliterative Surgery for the Treatment of Pelvic Organ Prolapse: A Patient Survey on Reasons for Surgery Selection and Postoperative Decision Regret and Satisfaction. Female Pelvic Medicine and Reconstructive Surgery. 2015;21(6):325–31. doi:10.1097/spv.0000000000000198.PubMedCrossRef Takase-Sanchez MM, Brooks HM, Hale DS, Heit MH. Obliterative Surgery for the Treatment of Pelvic Organ Prolapse: A Patient Survey on Reasons for Surgery Selection and Postoperative Decision Regret and Satisfaction. Female Pelvic Medicine and Reconstructive Surgery. 2015;21(6):325–31. doi:10.​1097/​spv.​0000000000000198​.PubMedCrossRef
55.
Zurück zum Zitat Sidana A, Hernandez DJ, Feng Z, Partin AW, Trock BJ, Saha S et al. Treatment decision-making for localized prostate cancer: what younger men choose and why. Prostate. 2012;72(1):58–64. doi:10.1002/pros.21406.PubMedCrossRef Sidana A, Hernandez DJ, Feng Z, Partin AW, Trock BJ, Saha S et al. Treatment decision-making for localized prostate cancer: what younger men choose and why. Prostate. 2012;72(1):58–64. doi:10.​1002/​pros.​21406.PubMedCrossRef
56.
Zurück zum Zitat Kavic SM, Kavic SM. Adhesions and adhesiolysis: the role of laparoscopy. JSLS : Journal of the Society of Laparoendoscopic Surgeons. 2002;6(2):99–109.PubMedPubMedCentral Kavic SM, Kavic SM. Adhesions and adhesiolysis: the role of laparoscopy. JSLS : Journal of the Society of Laparoendoscopic Surgeons. 2002;6(2):99–109.PubMedPubMedCentral
57.
Zurück zum Zitat Lower AM, Hawthorn RJ, Clark D, Boyd JH, Finlayson AR, Knight AD et al. Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients. Human reproduction (Oxford, England). 2004;19(8):1877–85. doi:10.1093/humrep/deh321.CrossRef Lower AM, Hawthorn RJ, Clark D, Boyd JH, Finlayson AR, Knight AD et al. Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients. Human reproduction (Oxford, England). 2004;19(8):1877–85. doi:10.​1093/​humrep/​deh321.CrossRef
58.
Zurück zum Zitat Scholin J, Buunen M, Hop W, Bonjer J, Anderberg B, Cuesta M et al. Bowel obstruction after laparoscopic and open colon resection for cancer: results of 5 years of follow-up in a randomized trial. Surgical endoscopy. 2011;25(12):3755–60. doi:10.1007/s00464-011-1782-2.PubMedCrossRef Scholin J, Buunen M, Hop W, Bonjer J, Anderberg B, Cuesta M et al. Bowel obstruction after laparoscopic and open colon resection for cancer: results of 5 years of follow-up in a randomized trial. Surgical endoscopy. 2011;25(12):3755–60. doi:10.​1007/​s00464-011-1782-2.PubMedCrossRef
61.
Zurück zum Zitat Loeb S, Meyer CP, Krasnova A, Curnyn C, Reznor G, Kibel AS et al. Risk of Small Bowel Obstruction After Robot-Assisted vs Open Radical Prostatectomy. Journal of endourology. 2016;30(12):1291–5. doi:10.1089/end.2016.0206.PubMedCrossRef Loeb S, Meyer CP, Krasnova A, Curnyn C, Reznor G, Kibel AS et al. Risk of Small Bowel Obstruction After Robot-Assisted vs Open Radical Prostatectomy. Journal of endourology. 2016;30(12):1291–5. doi:10.​1089/​end.​2016.​0206.PubMedCrossRef
62.
Zurück zum Zitat Lundorff P, Hahlin M, Källfelt B, Thorburn J, Lindblom B. Adhesion formation after laparoscopic surgery in tubal pregnancy: a randomized trial versus laparotomy. Fertil Steril. 1991;55(5):911–5.PubMedCrossRef Lundorff P, Hahlin M, Källfelt B, Thorburn J, Lindblom B. Adhesion formation after laparoscopic surgery in tubal pregnancy: a randomized trial versus laparotomy. Fertil Steril. 1991;55(5):911–5.PubMedCrossRef
63.
Zurück zum Zitat Diamond MP, Freeman ML. Clinical implications of postsurgical adhesions. Hum Reprod Update. 2001;7(6):567–76.PubMedCrossRef Diamond MP, Freeman ML. Clinical implications of postsurgical adhesions. Hum Reprod Update. 2001;7(6):567–76.PubMedCrossRef
64.
Zurück zum Zitat Risberg B. Adhesions: preventive strategies. The European journal of surgery Supplement : = Acta chirurgica Supplement. 1997(577):32–9. Risberg B. Adhesions: preventive strategies. The European journal of surgery Supplement : = Acta chirurgica Supplement. 1997(577):32–9.
65.
Zurück zum Zitat diZerega GS. Use of adhesion prevention barriers in pelvic reconstructive and gynecologic surgery. In: diZerega, editor. Peritoneal Surgery. New York: Springer; 2000. p. 379–99. diZerega GS. Use of adhesion prevention barriers in pelvic reconstructive and gynecologic surgery. In: diZerega, editor. Peritoneal Surgery. New York: Springer; 2000. p. 379–99.
66.
Zurück zum Zitat ten Broek RP, Stommel MW, Strik C, van Laarhoven CJ, Keus F, van Goor H. Benefits and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis. Lancet (London, England). 2014;383(9911):48–59. doi:10.1016/s0140-6736(13)61687-6.CrossRef ten Broek RP, Stommel MW, Strik C, van Laarhoven CJ, Keus F, van Goor H. Benefits and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis. Lancet (London, England). 2014;383(9911):48–59. doi:10.​1016/​s0140-6736(13)61687-6.CrossRef
67.
68.
Zurück zum Zitat Zeng Q, Yu Z, You J, Zhang Q. Efficacy and safety of Seprafilm for preventing postoperative abdominal adhesion: systematic review and meta-analysis. World journal of surgery. 2007;31(11):2125–31; discussion 32. doi:10.1007/s00268-007-9242-9.PubMedCrossRef Zeng Q, Yu Z, You J, Zhang Q. Efficacy and safety of Seprafilm for preventing postoperative abdominal adhesion: systematic review and meta-analysis. World journal of surgery. 2007;31(11):2125–31; discussion 32. doi:10.​1007/​s00268-007-9242-9.PubMedCrossRef
70.
Zurück zum Zitat Wiseman DM, Trout JR, Franklin RR, Diamond MP. Metaanalysis of the safety and efficacy of an adhesion barrier (Interceed TC7) in laparotomy. The Journal of reproductive medicine. 1999;44(4):325–31.PubMed Wiseman DM, Trout JR, Franklin RR, Diamond MP. Metaanalysis of the safety and efficacy of an adhesion barrier (Interceed TC7) in laparotomy. The Journal of reproductive medicine. 1999;44(4):325–31.PubMed
71.
Zurück zum Zitat Fazio VW, Cohen Z, Fleshman JW, van Goor H, Bauer JJ, Wolff BG et al. Reduction in adhesive small-bowel obstruction by Seprafilm adhesion barrier after intestinal resection. Diseases of the colon and rectum. 2006;49(1):1–11. doi:10.1007/s10350-005-0268-5.PubMedCrossRef Fazio VW, Cohen Z, Fleshman JW, van Goor H, Bauer JJ, Wolff BG et al. Reduction in adhesive small-bowel obstruction by Seprafilm adhesion barrier after intestinal resection. Diseases of the colon and rectum. 2006;49(1):1–11. doi:10.​1007/​s10350-005-0268-5.PubMedCrossRef
73.
Zurück zum Zitat Beck DE, Cohen Z, Fleshman JW, Kaufman HS, van Goor H, Wolff BG et al. A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine. Diseases of the colon and rectum. 2003;46(10):1310–9. doi:10.1097/01.DCR.0000089117.62296.E4.PubMedCrossRef Beck DE, Cohen Z, Fleshman JW, Kaufman HS, van Goor H, Wolff BG et al. A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine. Diseases of the colon and rectum. 2003;46(10):1310–9. doi:10.​1097/​01.​DCR.​0000089117.​62296.​E4.PubMedCrossRef
76.
Zurück zum Zitat Kiefer DG, Muscat JC, Santorelli J, Chavez MR, Ananth CV, Smulian JC et al. Effectiveness and short-term safety of modified sodium hyaluronic acid-carboxymethylcellulose at cesarean delivery: a randomized trial. American journal of obstetrics and gynecology. 2016;214(3):373 e1- e12. doi:10.1016/j.ajog.2015.10.012.CrossRef Kiefer DG, Muscat JC, Santorelli J, Chavez MR, Ananth CV, Smulian JC et al. Effectiveness and short-term safety of modified sodium hyaluronic acid-carboxymethylcellulose at cesarean delivery: a randomized trial. American journal of obstetrics and gynecology. 2016;214(3):373 e1- e12. doi:10.​1016/​j.​ajog.​2015.​10.​012.CrossRef
77.
Zurück zum Zitat Becker JM, Dayton MT, Fazio VW, Beck DE, Stryker SJ, Wexner SD et al. Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study. Journal of the American College of Surgeons. 1996;183(4):297–306.PubMed Becker JM, Dayton MT, Fazio VW, Beck DE, Stryker SJ, Wexner SD et al. Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study. Journal of the American College of Surgeons. 1996;183(4):297–306.PubMed
78.
Zurück zum Zitat Dasiran F, Eryilmaz R, Isik A, Okan I, Somay A, Sahin M. The effect of polyethylene glycol adhesion barrier (Spray Gel) on preventing peritoneal adhesions. Bratislavske lekarske listy. 2015;116(6):379–82.PubMed Dasiran F, Eryilmaz R, Isik A, Okan I, Somay A, Sahin M. The effect of polyethylene glycol adhesion barrier (Spray Gel) on preventing peritoneal adhesions. Bratislavske lekarske listy. 2015;116(6):379–82.PubMed
79.
Zurück zum Zitat Bothin C, Midtvedt T. The role of the gastrointestinal microflora in postsurgical adhesion formation—a study in germfree rats. European surgical research Europaische chirurgische Forschung Recherches chirurgicales europeennes. 1992;24(5):309–12.PubMedCrossRef Bothin C, Midtvedt T. The role of the gastrointestinal microflora in postsurgical adhesion formation—a study in germfree rats. European surgical research Europaische chirurgische Forschung Recherches chirurgicales europeennes. 1992;24(5):309–12.PubMedCrossRef
81.
Zurück zum Zitat Moris D, Felekouras E, Chrousos GP. No Cytokine Is an Island: IL-6 Alone Is not Sufficient to Predict Morbidity after a Major Abdominal Surgery. Annals of surgery. 2016. doi:10.1097/SLA.0000000000001977. Moris D, Felekouras E, Chrousos GP. No Cytokine Is an Island: IL-6 Alone Is not Sufficient to Predict Morbidity after a Major Abdominal Surgery. Annals of surgery. 2016. doi:10.​1097/​SLA.​0000000000001977​.
83.
Zurück zum Zitat Oncel M, Kurt N, Remzi FH, Sensu SS, Vural S, Gezen CF et al. The effectiveness of systemic antibiotics in preventing postoperative, intraabdominal adhesions in an animal model. The Journal of surgical research. 2001;101(1):52–5. doi:10.1006/jsre.2001.6245.PubMedCrossRef Oncel M, Kurt N, Remzi FH, Sensu SS, Vural S, Gezen CF et al. The effectiveness of systemic antibiotics in preventing postoperative, intraabdominal adhesions in an animal model. The Journal of surgical research. 2001;101(1):52–5. doi:10.​1006/​jsre.​2001.​6245.PubMedCrossRef
84.
Zurück zum Zitat Bothin C, Midtvedt T, Perbeck L. Orally delivered antibiotics which lower bacterial numbers decrease experimental intra-abdominal adhesions. Langenbeck's archives of surgery. 2003;388(2):112–5. doi:10.1007/s00423-003-0369-3.PubMed Bothin C, Midtvedt T, Perbeck L. Orally delivered antibiotics which lower bacterial numbers decrease experimental intra-abdominal adhesions. Langenbeck's archives of surgery. 2003;388(2):112–5. doi:10.​1007/​s00423-003-0369-3.PubMed
85.
Zurück zum Zitat Drago L, Toscano M, De Grandi R, Casini V, Pace F. Persisting changes of intestinal microbiota after bowel lavage and colonoscopy. European journal of gastroenterology & hepatology. 2016;28(5):532–7. doi:10.1097/MEG.0000000000000581.CrossRef Drago L, Toscano M, De Grandi R, Casini V, Pace F. Persisting changes of intestinal microbiota after bowel lavage and colonoscopy. European journal of gastroenterology & hepatology. 2016;28(5):532–7. doi:10.​1097/​MEG.​0000000000000581​.CrossRef
87.
Zurück zum Zitat Rodgers KE, Girgis W, Campeau JD, di Zerega GS. Reduction of adhesion formation by intraperitoneal administration of anti-inflammatory peptide 2. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 1997;10(1–2):31–6.CrossRef Rodgers KE, Girgis W, Campeau JD, di Zerega GS. Reduction of adhesion formation by intraperitoneal administration of anti-inflammatory peptide 2. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 1997;10(1–2):31–6.CrossRef
88.
Zurück zum Zitat Guvenal T, Cetin A, Ozdemir H, Yanar O, Kaya T. Prevention of postoperative adhesion formation in rat uterine horn model by nimesulide: a selective COX-2 inhibitor. Human Reproduction. 2001;16(8):1732–5.PubMedCrossRef Guvenal T, Cetin A, Ozdemir H, Yanar O, Kaya T. Prevention of postoperative adhesion formation in rat uterine horn model by nimesulide: a selective COX-2 inhibitor. Human Reproduction. 2001;16(8):1732–5.PubMedCrossRef
89.
Zurück zum Zitat Kirdak T, Uysal E, Korun N. Assessment of effectiveness of different doses of methylprednisolone on intraabdominal adhesion prevention. Ulusal travma ve acil cerrahi dergisi= Turkish journal of trauma & emergency surgery: TJTES. 2008;14(3):188–91. Kirdak T, Uysal E, Korun N. Assessment of effectiveness of different doses of methylprednisolone on intraabdominal adhesion prevention. Ulusal travma ve acil cerrahi dergisi= Turkish journal of trauma & emergency surgery: TJTES. 2008;14(3):188–91.
90.
Zurück zum Zitat Arung W, Meurisse M, Detry O. Pathophysiology and prevention of postoperative peritoneal adhesions. World journal of gastroenterology. 2011;17(41):4545–53.PubMedPubMedCentralCrossRef Arung W, Meurisse M, Detry O. Pathophysiology and prevention of postoperative peritoneal adhesions. World journal of gastroenterology. 2011;17(41):4545–53.PubMedPubMedCentralCrossRef
91.
Zurück zum Zitat Hong GS, Schwandt T, Stein K, Schneiker B, Kummer MP, Heneka MT et al. Effects of macrophage-dependent peroxisome proliferator-activated receptor γ signalling on adhesion formation after abdominal surgery in an experimental model. Br J Surg. 2015;102(12):1506–16. doi:10.1002/bjs.9907.PubMedCrossRef Hong GS, Schwandt T, Stein K, Schneiker B, Kummer MP, Heneka MT et al. Effects of macrophage-dependent peroxisome proliferator-activated receptor γ signalling on adhesion formation after abdominal surgery in an experimental model. Br J Surg. 2015;102(12):1506–16. doi:10.​1002/​bjs.​9907.PubMedCrossRef
92.
Zurück zum Zitat Javaherzadeh M, Shekarchizadeh A, Kafaei M, Mirafshrieh A, Mosaffa N, Sabet B. Effects of Intraperitoneal Administration of Simvastatin in Prevention of Postoperative Intra-abdominal Adhesion Formation in Animal Model of Rat. Bull Emerg Trauma. 2016;4(3):156–60.PubMedPubMedCentral Javaherzadeh M, Shekarchizadeh A, Kafaei M, Mirafshrieh A, Mosaffa N, Sabet B. Effects of Intraperitoneal Administration of Simvastatin in Prevention of Postoperative Intra-abdominal Adhesion Formation in Animal Model of Rat. Bull Emerg Trauma. 2016;4(3):156–60.PubMedPubMedCentral
93.
Zurück zum Zitat Brochhausen C, Schmitt VH, Rajab TK, Planck CN, Krämer B, Tapprich C et al. Mesothelial morphology and organisation after peritoneal treatment with solid and liquid adhesion barriers—a scanning electron microscopical study. J Mater Sci Mater Med. 2012;23(8):1931–9. doi:10.1007/s10856-012-4659-6.PubMedCrossRef Brochhausen C, Schmitt VH, Rajab TK, Planck CN, Krämer B, Tapprich C et al. Mesothelial morphology and organisation after peritoneal treatment with solid and liquid adhesion barriers—a scanning electron microscopical study. J Mater Sci Mater Med. 2012;23(8):1931–9. doi:10.​1007/​s10856-012-4659-6.PubMedCrossRef
94.
Zurück zum Zitat Chaturvedi AA, Lomme RM, Hendriks T, van Goor H. Prevention of postsurgical adhesions using an ultrapure alginate-based gel. The British journal of surgery. 2013;100(7):904–10. doi:10.1002/bjs.9131.PubMedCrossRef Chaturvedi AA, Lomme RM, Hendriks T, van Goor H. Prevention of postsurgical adhesions using an ultrapure alginate-based gel. The British journal of surgery. 2013;100(7):904–10. doi:10.​1002/​bjs.​9131.PubMedCrossRef
95.
Zurück zum Zitat Fredriksson F, Sellberg F, Bowden T, Engstrand T, Berglund D, Lilja HE. Sutures impregnated with carbazate-activated polyvinyl alcohol reduce intraperitoneal adhesions. J Pediatr Surg. 2017. doi:10.1016/j.jpedsurg.2017.01.058. Fredriksson F, Sellberg F, Bowden T, Engstrand T, Berglund D, Lilja HE. Sutures impregnated with carbazate-activated polyvinyl alcohol reduce intraperitoneal adhesions. J Pediatr Surg. 2017. doi:10.​1016/​j.​jpedsurg.​2017.​01.​058.
Metadaten
Titel
Postoperative Abdominal Adhesions: Clinical Significance and Advances in Prevention and Management
verfasst von
Demetrios Moris
Jeffery Chakedis
Amir A. Rahnemai-Azar
Ana Wilson
Mairead Marion Hennessy
Antonios Athanasiou
Eliza W. Beal
Chrysoula Argyrou
Evangelos Felekouras
Timothy M. Pawlik
Publikationsdatum
06.07.2017
Verlag
Springer US
Erschienen in
Journal of Gastrointestinal Surgery / Ausgabe 10/2017
Print ISSN: 1091-255X
Elektronische ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-017-3488-9

Weitere Artikel der Ausgabe 10/2017

Journal of Gastrointestinal Surgery 10/2017 Zur Ausgabe

Wie erfolgreich ist eine Re-Ablation nach Rezidiv?

23.04.2024 Ablationstherapie Nachrichten

Nach der Katheterablation von Vorhofflimmern kommt es bei etwa einem Drittel der Patienten zu Rezidiven, meist binnen eines Jahres. Wie sich spätere Rückfälle auf die Erfolgschancen einer erneuten Ablation auswirken, haben Schweizer Kardiologen erforscht.

Hinter dieser Appendizitis steckte ein Erreger

23.04.2024 Appendizitis Nachrichten

Schmerzen im Unterbauch, aber sonst nicht viel, was auf eine Appendizitis hindeutete: Ein junger Mann hatte Glück, dass trotzdem eine Laparoskopie mit Appendektomie durchgeführt und der Wurmfortsatz histologisch untersucht wurde.

Mehr Schaden als Nutzen durch präoperatives Aussetzen von GLP-1-Agonisten?

23.04.2024 Operationsvorbereitung Nachrichten

Derzeit wird empfohlen, eine Therapie mit GLP-1-Rezeptoragonisten präoperativ zu unterbrechen. Eine neue Studie nährt jedoch Zweifel an der Notwendigkeit der Maßnahme.

Ureterstriktur: Innovative OP-Technik bewährt sich

19.04.2024 EAU 2024 Kongressbericht

Die Ureterstriktur ist eine relativ seltene Komplikation, trotzdem bedarf sie einer differenzierten Versorgung. In komplexen Fällen wird dies durch die roboterassistierte OP-Technik gewährleistet. Erste Resultate ermutigen.

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.