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Inflammation Research
Erschienen in: Inflammation Research 3/2021

12.02.2021 | Original Research Paper

Potential of anthocyanin as an anti-inflammatory agent: a human clinical trial on type 2 diabetic, diabetic at-risk and healthy adults

verfasst von: Elham Nikbakht, Indu Singh, Jelena Vider, Lauren T. Williams, Lada Vugic, Almottesembellah Gaiz, Avinash Reddy Kundur, Natalie Colson

Erschienen in: Inflammation Research | Ausgabe 3/2021

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Abstract

Objective

The present research aimed to investigate the anti-inflammatory potential of dietary anthocyanin (ACN) in type 2 diabetic (T2D), T2D-at-risk and healthy individuals. Furthermore, dietary inflammatory index (DII) was used to study the association of diet with biomarkers of inflammation.

Research methods

An open-label clinical trial was conducted at Griffith University investigating the efficacy of 320 mg ACN supplementation per day over the course of 4 weeks. Diabetes-associated inflammatory biomarkers and relevant biochemical and physical parameters were tested pre-and post-intervention, and participants’ dietary inflammatory potential was estimated.

Results

A significant reduction in the pro-inflammatory biomarkers’ interleukin-6, interleukin-18, and tumour necrosis factor-α was observed in the T2D group. In addition, some, but not all, biochemical parameters including fasting blood glucose, low-density lipoprotein cholesterol and uric acid were significantly improved in T2D-at-risk group. Moreover, a significant difference was detected between the DII scores of the healthy and T2D groups. DII score for the T2D group was consistent with an anti-inflammatory diet.

Conclusion

Anti-inflammatory potential of dietary ACN in T2D participants was evidenced in the present study. Although, anti-inflammatory dietary patterns of T2D participants may have accelerated the anti-inflammatory effect of the ACN capsules supplemented in this trial.
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Literatur
1.
2.
Robertson RP, et al. β-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes. 2004;53(suppl 1):S119–24.PubMedCrossRef
3.
4.
Ferrante A. Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med. 2007;262(4):408–14.PubMedCrossRef
5.
Ferrero-Miliani L, et al. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol. 2007;147(2):227–35.PubMedPubMedCentralCrossRef
6.
Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol. 2011;29:415–45.PubMedCrossRef
7.
Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011;11(2):98–107.PubMedCrossRef
8.
9.
Shi Y, Hu FB. The global implications of diabetes and cancer. Lancet (London, England). 2014;383(9933):1947.CrossRef
10.
World Health Organization, Global report on diabetes. 2016.
11.
Burch E, et al. Dietary intake by food group of individuals with type 2 diabetes mellitus: A systematic review. Diabetes Res Clin Pract. 2018;137:160–72.PubMedCrossRef
12.
Donath MY, et al. Islet inflammation impairs the pancreatic β-cell in type 2 diabetes. Physiology. 2009;24(6):325–31.PubMedCrossRef
13.
Maki KC. Dietary factors in the prevention of diabetes mellitus and coronary artery disease associated with the metabolic syndrome. Am J Cardiol. 2004;93(11):12–7.CrossRef
14.
Fujioka K, et al. The effects of grapefruit on weight and insulin resistance: relationship to the metabolic syndrome. J Med Food. 2006;9(1):49–54.PubMedCrossRef
15.
Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000;52(4):673–751.PubMed
16.
Anhê FF, et al. Polyphenols and type 2 diabetes: A prospective review. PharmaNutrition. 2013;1(4):105–14.CrossRef
17.
Jayaprakasam B, et al. Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. J Agricul Food Chem. 2005;53(1):28–31.CrossRef
19.
20.
Dohadwala MM, et al. Effects of cranberry juice consumption on vascular function in patients with coronary artery disease. Am J Clin Nutr. 2011;93(5):934–40.PubMedPubMedCentralCrossRef
21.
22.
Dunstan DW, et al. The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes Obesity and Lifestyle Study. Diabetes Care. 2002;25(5):829–34.PubMedCrossRef
23.
Grundy SM. Pre-diabetes, metabolic syndrome, and cardiovascular risk. J Am Coll Cardiol. 2012;59(7):635–43.PubMedCrossRef
24.
25.
Qin Y, et al. Anthocyanin supplementation improves serum LDL-and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Am J Clin Nutr. 2009;90(3):485–92.PubMedCrossRef
26.
Karlsen A, et al. Anthocyanins inhibit nuclear factor-κ B activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults. J Nutr. 2007;137(8):1951–4.PubMedCrossRef
27.
Kelley DS, et al. Consumption of Bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women. J Nutr. 2006;136(4):981–6.PubMedCrossRef
28.
Cavicchia PP, et al. A new dietary inflammatory index predicts interval changes in serum high-sensitivity C-reactive protein. J Nutr. 2009;139(12):2365–72.PubMedPubMedCentralCrossRef
29.
Shivappa N, et al. Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr. 2014;17(8):1689–96.PubMedCrossRef
30.
World Health Organisation. Waist circumference and waist-hip ratio: report of a WHO expert consultation. Geneva. 2008;8–11:2011.
31.
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499–502.PubMedCrossRef
32.
Dacie JV, Lewis SM, Practical haematology. 2002.
33.
de Onis M, Habicht J-P. Anthropometric reference data for international use: recommendations from a World Health Organization Expert Committee. Am J Clin Nutr. 1996;64(4):650–8.PubMedCrossRef
34.
Whelton PK, et al. ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2017;2017:24430.
35.
Bastard JP, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw. 2006;17(1):4–12.PubMed
36.
Wu T, et al. Blackberry and Blueberry Anthocyanin Supplementation Counteract High-Fat-Diet-Induced Obesity by Alleviating Oxidative Stress and Inflammation and Accelerating Energy Expenditure. Oxid Med Cell Longev. 2018;2018:4051232.PubMedPubMedCentralCrossRef
37.
Tsalamandris S, et al. The role of inflammation in diabetes: current concepts and future perspectives. Eur Cardiol Rev. 2019;14(1):50.CrossRef
38.
Zhu Y, et al. Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial. Nutr Metabol Cardiovascular Dis. 2013;23(9):843–9.CrossRef
39.
Chen L, et al. Protective effects of raspberry on the oxidative damage in HepG2 cells through Keap1/Nrf2-dependent signaling pathway. Food Chem Toxicol. 2019;133:110781.PubMedCrossRef
40.
Shivappa N, et al. Associations between dietary inflammatory index and inflammatory markers in the Asklepios Study. Br J Nutr. 2015;113(4):665–71.PubMedPubMedCentralCrossRef
41.
King DE, Egan BM, Geesey ME. Relation of dietary fat and fiber to elevation of C-reactive protein. Am J Cardiol. 2003;92(11):1335–9.PubMedCrossRef
42.
Estruch R, et al. Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Intern Med. 2006;145(1):1–11.PubMedCrossRef
43.
Papamichou D, Panagiotakos D, Itsiopoulos C. Dietary patterns and management of type 2 diabetes: A systematic review of randomised clinical trials. Nutr Metabol Cardiovascular Dis. 2019;29(6):531–43.CrossRef
44.
Kitabchi AE, et al. Effects of high-protein versus high-carbohydrate diets on markers of β-cell function, oxidative stress, lipid peroxidation, proinflammatory cytokines, and adipokines in obese, premenopausal women without diabetes: a randomized controlled trial. Diabetes Care. 2013;36(7):1919–25.PubMedPubMedCentralCrossRef
45.
Ferrucci L, et al. Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers. J Clin Endocrinol Metabol . 2006;91(2):439–46.CrossRef
46.
Wannamethee SG, et al. Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis. Am J Clin Nutr. 2006;83(3):567–74.PubMedCrossRef
47.
Bertran N, et al. Diet and lifestyle are associated with serum C-reactive protein concentrations in a population-based study. J Labor Clin Med. 2005;145(1):41–6.CrossRef
48.
Erlinger TP, et al. Relationship between systemic markers of inflammation and serum β-carotene levels. Arch Intern Med. 2001;161(15):1903–8.PubMedCrossRef
49.
King DE, et al. Dietary magnesium and C-reactive protein levels. J Am Coll Nutr. 2005;24(3):166–71.PubMedCrossRef
50.
Ma Y, et al. Association between dietary fiber and serum C-reactive protein. Am J Clin Nutr. 2006;83(4):760–6.PubMedCrossRef
51.
Association AD. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2006;29(1):S43.CrossRef
52.
Hashem Dabaghian F, et al. Effects of Rosa canina Lfruit on glycemia and lipid profile in type 2 diabetic patients: A randomized, double-blind, placebo-controlled clinical trial. J Med Plants. 2015;14(55):95–104.
53.
Li D, et al. Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients. J Nutr. 2015;145(4):742–8.PubMedCrossRef
54.
American Diabetes. A Peripheral arterial disease in people with diabetes. Diabetes Care, 2003; 26(12)
55.
Dehghan A, et al. High serum uric acid as a novel risk factor for type 2 diabetes. Diabetes Care. 2008;31(2):361–2.PubMedCrossRef
56.
Jacob RA, et al. Consumption of cherries lowers plasma urate in healthy women. J Nutr. 2003;133(6):1826–9.PubMedCrossRef
57.
Zhu JX, et al. Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver. J Ethnopharmacol. 2004;93(1):133–40.PubMedCrossRef
Metadaten
Titel
Potential of anthocyanin as an anti-inflammatory agent: a human clinical trial on type 2 diabetic, diabetic at-risk and healthy adults
verfasst von
Elham Nikbakht
Indu Singh
Jelena Vider
Lauren T. Williams
Lada Vugic
Almottesembellah Gaiz
Avinash Reddy Kundur
Natalie Colson
Publikationsdatum
12.02.2021
Verlag
Springer International Publishing
Erschienen in
Inflammation Research / Ausgabe 3/2021
Print ISSN: 1023-3830
Elektronische ISSN: 1420-908X
DOI
https://doi.org/10.1007/s00011-021-01438-1

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