Introduction
Methods
General information on subjects
Parameters | Data | |
---|---|---|
Number of patients | 65 | |
Age (years old) | 35-55 | |
Average age (years old) | 46.6±9.1 | |
Height (cm) | 163.3±5.6 | |
Weight (kg) | 53±5.3 | |
Body mass index (kg/m2) | 25.6±3.9 | |
TNM staging (number of patients) | T1 T2 T3 | 13 33 19 |
Inclusion and exclusion criteria
Inclusion criteria
Exclusion criteria
Neoadjuvant chemotherapy regimens
Parameters measured
Assay of serum markers
Measurement of DCE-MRI
Measurement of DWI
Assessment of effectiveness of neoadjuvant chemotherapy in the two groups of patients
Statistical analysis
Results
Comparison of DCE-MRI quantitative parameters before and after neoadjuvant chemotherapy
Indexes | Group | Number of cases | Before chemotherapy | After chemotherapy | t | P |
---|---|---|---|---|---|---|
Kep (/min) | Remission group | 39 | 1.79±0.5 | 0.79±0.27 | 9.32 | <0.01 |
Ineffective group | 26 | 1.67±0.53 | 1.51±0.53 | 1.19 | >0.05 | |
t | 0.93 | 7.21 | ||||
P | >0.05 | <0.01 | ||||
Ktrans (/min) | Remission group | 39 | 1.39±0.51 | 0.67±0.29 | ||
Ineffective group | 26 | 1.27±0.51 | 1.13±0.33 | 6.52 | <0.01 | |
t | 0.93 | 5.93 | 1.24 | >0.05 | ||
P | 0.36 | 0.00 | ||||
Remission group Ve | 39 | 0.75±0.31 | 0.77±0.19 | 0.29 | <0.01 | |
Ineffective group Ve | 26 | 0.83±0.33 | 0.85±0.13 | 0.29 | >0.05 | |
t | 0.99 | 1.87 | ||||
P | >0.05 | >0.05 |
Comparison of DWI results before and after neoadjuvant chemotherapy
Indexes | Group | Number of cases | Before chemotherapy | After chemotherapy | t | P |
---|---|---|---|---|---|---|
ADCmin | Remission | 39 | 0.72±0.16 | 1.39±0.21 | 15.85 | <0.01 |
Ineffective | 26 | 0.69±0.13 | 0.79±0.19 | 2.21 | <0.05 | |
t | 0.80 | 11.71 | ||||
P | >0.05 | <0.01 | ||||
ADCmean | Remission | 39 | 0.77±0.19 | 1.46±0.23 | 14.44 | <0.01 |
Ineffective | 26 | 0.74±0.17 | 0.87±0.13 | 3.10 | <0.01 | |
t | 0.65 | 11.86 | ||||
P | >0.05 | <0.01 |