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Erschienen in: Pediatric Nephrology 2/2010

01.02.2010 | Original Article

Pre- and postcaptopril renal scintigraphy as a screening test for renovascular hypertension in children

verfasst von: Sameh Abdulsamea, Peter Anderson, Lorenzo Biassoni, Eileen Brennan, Clare A. McLaren, Stephen D. Marks, Derek J. Roebuck, Sabry Selim, Kjell Tullus

Erschienen in: Pediatric Nephrology | Ausgabe 2/2010

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Abstract

We studied the ability of pre- and postcaptopril renal scintigraphy to predict renovascular disease (RVD) in children. Retrospective review of medical notes and radiology reports of all hypertensive children who had had both pre- and postcaptopril renal scintigraphy with [99mTc] dimercaptosuccinic acid (DMSA) and/or [99mTc] mercaptoacetyltriglycine (MAG3) and digital subtraction angiography (DSA). 81 children aged 1–18 (median 10) years were studied with 62% (51) having a diagnosis of RVD. Main renal artery disease, intrarenal disease, and both main and intrarenal artery disease were present in 25, 14, and 12 patients respectively. The isotope study accurately diagnosed RVD, confirmed by DSA, in 47% (24 of 51) children, with eight false positive studies. The sensitivity, specificity, and positive and negative predictive values of the isotope study to predict RVD were 48%, 73%, 76%, and 51%, respectively. Pre- and postcaptopril renal scintigraphy was unable to predict RVD in children.
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Metadaten
Titel
Pre- and postcaptopril renal scintigraphy as a screening test for renovascular hypertension in children
verfasst von
Sameh Abdulsamea
Peter Anderson
Lorenzo Biassoni
Eileen Brennan
Clare A. McLaren
Stephen D. Marks
Derek J. Roebuck
Sabry Selim
Kjell Tullus
Publikationsdatum
01.02.2010
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Nephrology / Ausgabe 2/2010
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-009-1304-9

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