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Annals of Surgical Oncology
Erschienen in: Annals of Surgical Oncology 4/2016

01.04.2016 | Colorectal Cancer

Predictors of Pathologic Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer

verfasst von: Eisar Al-Sukhni, MD, MSc, Kristopher Attwood, PhD, David M. Mattson, MD, Emmanuel Gabriel, MD, PhD, Steven J. Nurkin, MD, MS

Erschienen in: Annals of Surgical Oncology | Ausgabe 4/2016

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Abstract

Background

Some patients with rectal cancer who receive neoadjuvant chemoradiotherapy (nCRT) achieve a pathologic complete response (pCR) and may be eligible for less radical surgery or non-operative management. The aim of this study was to identify variables that predict pCR after nCRT for rectal cancer and to examine the impact of pCR on postoperative complications.

Methods

A retrospective review was performed of the NCDB from 2006 to 2011. Patients with rectal cancer who received nCRT followed by radical resection were included in this study. Multivariable analysis of the association between clinicopathologic characteristics and pCR was performed, and propensity-adjusted analysis was used to identify differences in postoperative morbidity between pCR and non-pCR patients.

Results

A total of 23,747 patients were included in the study. Factors associated with pCR included lower tumor grade, lower clinical T and N stage, higher radiation dose, and delaying surgery by more than 6–8 weeks after the end of radiation, while lack of health insurance was linked with a lower likelihood of pCR. Complete response was not associated with an increased risk of major postoperative complications.

Conclusions

Several clinical, pathologic, and treatment variables can help to predict which patients are most likely to have pCR after nCRT for rectal cancer. Awareness of these variables can be valuable in counseling patients regarding prognosis and treatment options.
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Metadaten
Titel
Predictors of Pathologic Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer
verfasst von
Eisar Al-Sukhni, MD, MSc
Kristopher Attwood, PhD
David M. Mattson, MD
Emmanuel Gabriel, MD, PhD
Steven J. Nurkin, MD, MS
Publikationsdatum
01.04.2016
Verlag
Springer International Publishing
Erschienen in
Annals of Surgical Oncology / Ausgabe 4/2016
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-015-5017-y

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