Excerpt
Breast cancer, the most common malignancy in women, begins as a local disease and later metastasizes to the lymph nodes and multiple vital organs, such as the lung, liver, bone, and brain. Metastatic, or stage IV breast cancers, have a 5-year survival rate of about 22%. Despite great efforts in biomedical research into breast cancer, metastasis and therapy resistance remain major obstacles in ending breast cancer and breast cancer-related death and suffering. In this thematic tissue of cancer and metastasis reviews, we bring to our readers a panel of experts who are highlighting the recent advances in breast cancer research and treatment. …