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Cancer and Metastasis Reviews

Erschienen in:

02.12.2016

From transformation to metastasis: deconstructing the extracellular matrix in breast cancer

verfasst von: Shelly Kaushik, Michael W Pickup, Valerie M Weaver

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 4/2016

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Abstract

The extracellular matrix (ECM) is a guiding force that regulates various developmental stages of the breast. In addition to providing structural support for the cells, it mediates epithelial-stromal communication and provides cues for cell survival, proliferation, and differentiation. Perturbations in ECM architecture profoundly influence breast tumor progression and metastasis. Understanding how a dysregulated ECM can facilitate malignant transformation is crucial to designing treatments to effectively target the tumor microenvironment. Here, we address the contribution of ECM mechanics to breast cancer progression, metastasis, and treatment resistance and discuss potential therapeutic strategies targeting the ECM.

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Titel: From transformation to metastasis: deconstructing the extracellular matrix in breast cancer
verfasst von: Shelly Kaushik
Michael W Pickup
Valerie M Weaver
Publikationsdatum: 02.12.2016
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 4/2016
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-016-9650-0

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Springer Medizin

From transformation to metastasis: deconstructing the extracellular matrix in breast cancer

Abstract

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