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01.04.2009 | Original Article

Preliminary result of accelerated partial breast irradiation after breast-conserving surgery

verfasst von: Ken Yoshida, Takayuki Nose, Norikazu Masuda, Hideya Yamazaki, Tadayuki Kotsuma, Mineo Yoshida, Jun Yamamura, Hiroko Masuda, Eisei Shin, Hiroyuki Nakaba, Yoshifumi Komoike, Yukiko Tokuda, Masashi Takeda, Keiko Kuriyama

Erschienen in: Breast Cancer | Ausgabe 2/2009

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Abstract

Purpose

To investigate the feasibility of accelerated partial breast irradiation (APBI) for Japanese patients, we started high-dose-rate interstitial brachytherapy (HDR-ISBT) as monotherapy after breast-conserving surgery (BCS).

Methods

We implanted 45 Tis-2 breast cancer patients at National Hospital Organization Osaka National Hospital between June 2002 and June 2006. Our eligibility criteria were broader than the ones used previously in western countries. We included margin-positive cases and younger patients (median age: 44; range: 26–68) to adapt the criteria for Japanese women. Total prescribed doses were 36–42 Gy in six to seven fractions, and the volumes encompassed by 100% prescribed dose (V100) were 38.5–315.1 cc. Fifteen patients received chemotherapy.

Results

Treatment could be completed for all patients. Two local failures (4%) and two distant metastases were observed, while one patient died of liver metastasis. Seven wound complications, four with and three without infection, and two rib fractures occurred. The significant risk factors for wound complications were non-administration of prophylactic antibiotics during ISBT (P < 0.01), open cavity implant (P < 0.05), large V100 (P < 0.01), V150 (P < 0.05), and V200 (P < 0.05).

Conclusion

APBI after BCS for Japanese women with relatively small breasts was well tolerated, but special care should be taken with treatment technique.

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Titel: Preliminary result of accelerated partial breast irradiation after breast-conserving surgery
verfasst von: Ken Yoshida
Takayuki Nose
Norikazu Masuda
Hideya Yamazaki
Tadayuki Kotsuma
Mineo Yoshida
Jun Yamamura
Hiroko Masuda
Eisei Shin
Hiroyuki Nakaba
Yoshifumi Komoike
Yukiko Tokuda
Masashi Takeda
Keiko Kuriyama
Publikationsdatum: 01.04.2009
Verlag: Springer Japan
Erschienen in: Breast Cancer / Ausgabe 2/2009
Print ISSN: 1340-6868
Elektronische ISSN: 1880-4233
DOI: https://doi.org/10.1007/s12282-008-0067-7

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Preliminary result of accelerated partial breast irradiation after breast-conserving surgery