nach oben

Erschienen in:

23.10.2017 | Original Article

Prenatal methamphetamine exposure is associated with corticostriatal white matter changes in neonates

verfasst von: Fleur L. Warton, Paul A. Taylor, Christopher M. R. Warton, Christopher D. Molteno, Pia Wintermark, Nadine M. Lindinger, Lilla Zöllei, Andre van der Kouwe, Joseph L. Jacobson, Sandra W. Jacobson, Ernesta M. Meintjes

Erschienen in: Metabolic Brain Disease | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

Diffusion tensor imaging (DTI) studies have shown that prenatal exposure to methamphetamine is associated with alterations in white matter microstructure, but to date no tractography studies have been performed in neonates. The striato-thalamo-orbitofrontal circuit and its associated limbic-striatal areas, the primary circuit responsible for reinforcement, has been postulated to be dysfunctional in drug addiction. This study investigated potential white matter changes in the striatal-orbitofrontal circuit in neonates with prenatal methamphetamine exposure. Mothers were recruited antenatally and interviewed regarding methamphetamine use during pregnancy, and DTI sequences were acquired in the first postnatal month. Target regions of interest were manually delineated, white matter bundles connecting pairs of targets were determined using probabilistic tractography in AFNI-FATCAT, and fractional anisotropy (FA) and diffusion measures were determined in white matter connections. Regression analysis showed that increasing methamphetamine exposure was associated with reduced FA in several connections between the striatum and midbrain, orbitofrontal cortex, and associated limbic structures, following adjustment for potential confounding variables. Our results are consistent with previous findings in older children and extend them to show that these changes are already evident in neonates. The observed alterations are likely to play a role in the deficits in attention and inhibitory control frequently seen in children with prenatal methamphetamine exposure.

Alexander AL, Lee JE, Lazar M, Field AS (2007) Diffusion tensor imaging of the brain. Neurotherapeutics 4:316–329. https://doi.org/10.1016/j.nurt.2007.05.011 CrossRefPubMedPubMedCentral

Alhamud A, Tisdall MD, Hess AT et al (2012) Volumetric navigators for real-time motion correction in diffusion tensor imaging. Magn Reson Med 68:1097–1108. https://doi.org/10.1002/mrm.23314 CrossRefPubMedPubMedCentral

Alicata D, Chang L, Cloak C et al (2009) Higher diffusion in striatum and lower fractional anisotropy in white matter of methamphetamine users. Psychiatry Res 174:1–8. https://doi.org/10.1016/j.pscychresns.2009.03.011 CrossRefPubMedPubMedCentral

Aron AR, Robbins TW, Poldrack RA (2004) Inhibition and the right inferior frontal cortex. Trends Cogn Sci 8:170–177. https://doi.org/10.1016/j.tics.2004.02.010 CrossRefPubMed

Arria AM, Derauf C, Lagasse LL et al (2006) Methamphetamine and other substance use during pregnancy: preliminary estimates from the infant development, environment, and lifestyle (IDEAL) study. Matern Child Health J 10:293–302. https://doi.org/10.1007/s10995-005-0052-0 CrossRefPubMed

Assaf Y, Pasternak O (2008) Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review. J Mol Neurosci 34:51–61. https://doi.org/10.1007/s12031-007-0029-0 CrossRefPubMed

Avants BB, Hackman DA, Betancourt LM et al (2015) Relation of childhood home environment to cortical thickness in late adolescence: specificity of experience and timing. PLoS One 10:e0138217. https://doi.org/10.1371/journal.pone.0138217 CrossRefPubMedPubMedCentral

Beaulieu C (2002) The basis of anisotropic water diffusion in the nervous system - a technical review. NMR Biomed 15:435–455. https://doi.org/10.1002/nbm.782 CrossRefPubMed

Bonelli RM, Cummings JL (2007) Frontal-subcortical circuitry and behavior. Dialogues Clin Neurosci 9:141–151. https://doi.org/10.1001/archneur.1993.00540080076020 PubMedPubMedCentral

Brazelton TB (1984) Neonatal behavioral assessment scale, 2nd edn. J.B. Lippincott Co, Philadelphia

Carter RC, Wainwright H, Molteno CD et al (2016) Alcohol, methamphetamine, and marijuana exposure have distinct effects on the human placenta. Alcohol Clin Exp Res 40:753–764. https://doi.org/10.1111/acer.13022 CrossRefPubMed

Chang L, Smith LM, LoPresti C et al (2004) Smaller subcortical volumes and cognitive deficits in children with prenatal methamphetamine exposure. Psychiatry Res 132:95–106. https://doi.org/10.1016/j.pscychresns.2004.06.004 CrossRefPubMed

Chang L, Cloak C, Patterson K et al (2005) Enlarged striatum in abstinent methamphetamine abusers: a possible compensatory response. Biol Psychiatry 57:967–974. https://doi.org/10.1016/j.biopsych.2005.01.039 CrossRefPubMedPubMedCentral

Chang L, Oishi K, Skranes J et al (2016) Sex-specific alterations of white matter developmental trajectories in infants with prenatal exposure to methamphetamine and tobacco. JAMA psychiatry 73:1217–1227. https://doi.org/10.1001/jamapsychiatry.2016.2794 CrossRefPubMed

Cloak CC, Ernst T, Fujii L et al (2009) Lower diffusion in white matter of children with prenatal methamphetamine exposure. Neurology 72:2068–2075. https://doi.org/10.1212/01.wnl.0000346516.49126.20 CrossRefPubMedPubMedCentral

Colby JB, Smith L, O’Connor MJ et al (2012) White matter microstructural alterations in children with prenatal methamphetamine/polydrug exposure. Psychiatry Res 204:140–148. https://doi.org/10.1016/j.pscychresns.2012.04.017 CrossRefPubMedPubMedCentral

Cole DM, Beckmann CF, Searle GE et al (2012) Orbitofrontal connectivity with resting-state networks is associated with midbrain dopamine D3 receptor availability. Cereb Cortex 22:2784–2793. https://doi.org/10.1093/cercor/bhr354 CrossRefPubMed

Courtney KE, Ray LA (2014) Methamphetamine: an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature. Drug Alcohol Depend 143:11–21. https://doi.org/10.1016/j.drugalcdep.2014.08.003 CrossRefPubMed

Cox RW (1996) AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 29:162–173. https://doi.org/10.1006/cbmr.1996.0014 CrossRefPubMed

Degenhardt L, Baxter AJ, Lee YY et al (2014) The global epidemiology and burden of psychostimulant dependence: findings from the global burden of disease study 2010. Drug Alcohol Depend 137:36–47. https://doi.org/10.1016/j.drugalcdep.2013.12.025 CrossRefPubMed

Derauf C, Lagasse LL, Smith LM et al (2012) Prenatal methamphetamine exposure and inhibitory control among young school-age children. J Pediatr 161:452–459. https://doi.org/10.1016/j.jpeds.2012.02.002 CrossRefPubMedPubMedCentral

Duan J-H, Wang H-Q, Xu J et al (2006) White matter damage of patients with Alzheimer’s disease correlated with the decreased cognitive function. Surg Radiol Anat 28:150–156. https://doi.org/10.1007/s00276-006-0111-2 CrossRefPubMed

Dubois J, Hertz-Pannier L, Dehaene-Lambertz G et al (2006) Assessment of the early organization and maturation of infants’ cerebral white matter fiber bundles: a feasibility study using quantitative diffusion tensor imaging and tractography. NeuroImage 30:1121–1132. https://doi.org/10.1016/j.neuroimage.2005.11.022 CrossRefPubMed

Dubois J, Dehaene-Lambertz G, Kulikova S et al (2014) The early development of brain white matter: a review of imaging studies in fetuses, newborns and infants. Neuroscience 276:48–71. https://doi.org/10.1016/j.neuroscience.2013.12.044 CrossRefPubMed

Feldman HM, Yeatman JD, Lee ES et al (2010) Diffusion tensor imaging: a review for pediatric researchers and clinicians. J Dev Behav Pediatr 31:346–356. https://doi.org/10.1097/DBP.0b013e3181dcaa8b CrossRefPubMedPubMedCentral

Fischl B, Salat DH, van der Kouwe AJW et al (2004) Sequence-independent segmentation of magnetic resonance images. NeuroImage 23(Suppl 1):S69–S84. https://doi.org/10.1016/j.neuroimage.2004.07.016 CrossRefPubMed

Gau SS, Tseng W-L, Tseng W-YI et al (2015) Association between microstructural integrity of frontostriatal tracts and school functioning: ADHD symptoms and executive function as mediators. Psychol Med 45:529–543. https://doi.org/10.1017/S0033291714001664 CrossRefPubMed

Genc K, Genc S, Kizildag S et al (2003) Methamphetamine induces oligodendroglial cell death in vitro. Brain Res 982:125–130. https://doi.org/10.1016/S0006-8993(03)02890-7 CrossRefPubMed

Gorman MC, Orme KS, Nguyen NT et al (2014) Outcomes in pregnancies complicated by methamphetamine use. Am J Obstet Gynecol 211:429.e1–429.e7. https://doi.org/10.1016/j.ajog.2014.06.005 CrossRef

Haber SN, Kunishio K, Mizobuchi M, Lynd-Balta E (1995) The orbital and medial prefrontal circuit through the primate basal ganglia. J Neurosci 15:4851–4867PubMed

Himes SK, LaGasse LL, Derauf C et al (2014) Risk of neurobehavioral disinhibition in prenatal methamphetamine-exposed young children with positive hair toxicology results. Ther Drug Monit 36:535–543. https://doi.org/10.1097/FTD.0000000000000049 CrossRefPubMedPubMedCentral

Hollingshead AB (2011) Four factor index of social status. Yale. J Sociol 8:21–52

Hüppi PS, Dubois J (2006) Diffusion tensor imaging of brain development. Semin Fetal Neonatal Med 11:489–497. https://doi.org/10.1016/j.siny.2006.07.006 CrossRefPubMed

Jacobsen LK, Picciotto MR, Heath CJ et al (2007) Prenatal and adolescent exposure to tobacco smoke modulates the development of white matter microstructure. J Neurosci 27:13491–13498. https://doi.org/10.1523/JNEUROSCI.2402-07.2007 CrossRefPubMed

Jacobson SW, Chiodo LM, Sokol RJ, Jacobson JL (2002) Validity of maternal report of prenatal alcohol, cocaine, and smoking in relation to neurobehavioral outcome. Pediatrics 109:815–825. https://doi.org/10.1542/peds.109.5.815 CrossRefPubMed

Jacobson SW, Jacobson JL, Molteno CD et al (2017) Heavy prenatal alcohol exposure is related to smaller corpus callosum in newborn MRI scans. Alcohol Clin Exp Res 41:965–975. https://doi.org/10.1111/acer.13363 CrossRefPubMed

Jarbo K, Verstynen TD (2015) Converging structural and functional connectivity of orbitofrontal, dorsolateral prefrontal, and posterior parietal cortex in the human striatum. J Neurosci 35:3865–3878. https://doi.org/10.1523/JNEUROSCI.2636-14.2015 CrossRefPubMedPubMedCentral

Kiblawi ZN, Smith LM, LaGasse LL et al (2013) The effect of prenatal methamphetamine exposure on attention as assessed by continuous performance tests: results from the infant development, environment, and lifestyle study. J Dev Behav Pediatr 34:31–37. https://doi.org/10.1097/DBP.0b013e318277a1c5 PubMedPubMedCentral

Kim I-S, Kim Y-T, Song H-J et al (2009) Reduced corpus callosum white matter microstructural integrity revealed by diffusion tensor eigenvalues in abstinent methamphetamine addicts. Neurotoxicology 30:209–213. https://doi.org/10.1016/j.neuro.2008.12.002 CrossRefPubMed

Kwiatkowski MA, Donald KA, Stein DJ et al (2017) Cognitive outcomes in prenatal methamphetamine exposed children aged six to seven years. Compr Psychiatry. https://doi.org/10.1016/j.comppsych.2017.08.003

Ladhani NNN, Shah PS, Murphy KE, Knowledge Synthesis Group on Determinants of Preterm/LBW Births (2011) Prenatal amphetamine exposure and birth outcomes: a systematic review and metaanalysis. Am J Obstet Gynecol 205:219e1–219e7. https://doi.org/10.1016/j.ajog.2011.04.016 CrossRef

LaGasse LL, Wouldes T, Newman E et al (2011) Prenatal methamphetamine exposure and neonatal neurobehavioral outcome in the USA and New Zealand. Neurotoxicol Teratol 33:166–175. https://doi.org/10.1016/j.ntt.2010.06.009 CrossRefPubMed

Laswad T, Wintermark P, Alamo L et al (2009) Method for performing cerebral perfusion-weighted MRI in neonates. Pediatr Radiol 39:260–264. https://doi.org/10.1007/s00247-008-1081-9 CrossRefPubMed

Liu J, Cohen RA, Gongvatana A et al (2011) Impact of prenatal exposure to cocaine and tobacco on diffusion tensor imaging and sensation seeking in adolescents. J Pediatr 159(5):771. https://doi.org/10.1016/j.jpeds.2011.05.020 CrossRefPubMedPubMedCentral

Lloyd SA, Oltean C, Pass H et al (2013) Prenatal exposure to psychostimulants increases impulsivity, compulsivity, and motivation for rewards in adult mice. Physiol Behav 119:43–51. https://doi.org/10.1016/j.physbeh.2013.05.038 CrossRefPubMed

London ED, Berman SM, Voytek B et al (2005) Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers. Biol Psychiatry 58:770–778. https://doi.org/10.1016/j.biopsych.2005.04.039 CrossRefPubMed

Mabbott DJ, Noseworthy M, Bouffet E et al (2006) White matter growth as a mechanism of cognitive development in children. NeuroImage 33:936–946. https://doi.org/10.1016/j.neuroimage.2006.07.024 CrossRefPubMed

McDonnell-Dowling K, Donlon M, Kelly JP (2014) Methamphetamine exposure during pregnancy at pharmacological doses produces neurodevelopmental and behavioural effects in rat offspring. Int J Dev Neurosci 35:42–51. https://doi.org/10.1016/j.ijdevneu.2014.03.005 CrossRefPubMed

Meade CS, Towe SL, Watt MH et al (2015) Addiction and treatment experiences among active methamphetamine users recruited from a township community in cape town, South Africa: a mixed-methods study. Drug Alcohol Depend 152:79–86. https://doi.org/10.1016/j.drugalcdep.2015.04.016 CrossRefPubMedPubMedCentral

Melo P, Moreno VZ, Vázquez SP et al (2006) Myelination changes in the rat optic nerve after prenatal exposure to methamphetamine. Brain Res 1106:21–29. https://doi.org/10.1016/j.brainres.2006.05.020 CrossRefPubMed

Mitter C, Prayer D, Brugger PC et al (2015) In vivo tractography of fetal association fibers. PLoS One 10:e0119536. https://doi.org/10.1371/journal.pone.0119536 CrossRefPubMedPubMedCentral

Mori S, Zhang J (2006) Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron 51:527–539. https://doi.org/10.1016/j.neuron.2006.08.012 CrossRefPubMed

Nakano K (2000) Neural circuits and topographic organization of the basal ganglia and related regions. Brain and Development 22(Suppl 1):S5–16CrossRefPubMed

Nguyen D, Smith LM, Lagasse LL et al (2010) Intrauterine growth of infants exposed to prenatal methamphetamine: results from the infant development, environment, and lifestyle study. J Pediatr 157:337–339. https://doi.org/10.1016/j.jpeds.2010.04.024 CrossRefPubMedPubMedCentral

Orikabe L, Yamasue H, Inoue H et al (2011) Reduced amygdala and hippocampal volumes in patients with methamphetamine psychosis. Schizophr Res 132:183–189. https://doi.org/10.1016/j.schres.2011.07.006 CrossRefPubMed

Ouyang A, Jeon T, Sunkin SM et al (2015) Spatial mapping of structural and connectional imaging data for the developing human brain with diffusion tensor imaging. Methods 73:27–37. https://doi.org/10.1016/j.ymeth.2014.10.025 CrossRefPubMed

Panenka WJ, Procyshyn RM, Lecomte T et al (2013) Methamphetamine use: a comprehensive review of molecular, preclinical and clinical findings. Drug Alcohol Depend 129:167–179. https://doi.org/10.1016/j.drugalcdep.2012.11.016 CrossRefPubMed

Peltzer K, Ramlagan S, Johnson BD, Phaswana-Mafuya N (2010) Illicit drug use and treatment in South Africa: a review. Subst Use Misuse 45:2221–2243. https://doi.org/10.3109/10826084.2010.481594 CrossRefPubMedPubMedCentral

Petersen Williams P, Jordaan E, Mathews C et al (2014) Alcohol and other drug use during pregnancy among women attending midwife obstetric units in the cape metropole, South Africa. Adv Prev Med 2014:871427. https://doi.org/10.1155/2014/871427 CrossRefPubMedPubMedCentral

Piper BJ, Acevedo SF, Kolchugina GK et al (2011) Abnormalities in parentally rated executive function in methamphetamine/polysubstance exposed children. Pharmacol Biochem Behav 98:432–439. https://doi.org/10.1016/j.pbb.2011.02.013 CrossRefPubMedPubMedCentral

Qiu A, Mori S, Miller MI (2015) Diffusion tensor imaging for understanding brain development in early life. Annu Rev Psychol 66:853–876. https://doi.org/10.1146/annurev-psych-010814-015340 CrossRefPubMedPubMedCentral

Riddle EL, Fleckenstein AE, Hanson GR (2006) Mechanisms of methamphetamine-induced dopaminergic neurotoxicity. AAPS J 8:E413–E418CrossRefPubMedPubMedCentral

Rolls ET (2004) The functions of the orbitofrontal cortex. Brain Cogn 55:11–29. https://doi.org/10.1016/S0278-2626(03)00277-X CrossRefPubMed

Roos A, Jones G, Howells FM et al (2014) Structural brain changes in prenatal methamphetamine-exposed children. Metab Brain Dis 29:341–349. https://doi.org/10.1007/s11011-014-9500-0 CrossRefPubMed

Roos A, Kwiatkowski MA, Fouche J et al (2015) White matter integrity and cognitive performance in children with prenatal methamphetamine exposure. Behav Brain Res 279:62–67. https://doi.org/10.1016/j.bbr.2014.11.005 CrossRefPubMed

Roussotte FF, Bramen JE, Nunez SC et al (2011) Abnormal brain activation during working memory in children with prenatal exposure to drugs of abuse: the effects of methamphetamine, alcohol, and polydrug exposure. NeuroImage 54:3067–3075. https://doi.org/10.1016/j.neuroimage.2010.10.072 CrossRefPubMed

Saad ZS, Reynolds RC (2012) SUMA. NeuroImage 62:768–773. https://doi.org/10.1016/j.neuroimage.2011.09.016 CrossRefPubMed

Shang CY, YH W, Gau SS, Tseng WY (2013) Disturbed microstructural integrity of the frontostriatal fiber pathways and executive dysfunction in children with attention deficit hyperactivity disorder. Psychol Med 43:1093–1107. https://doi.org/10.1017/S0033291712001869 CrossRefPubMed

Smith LM, Chang L, Yonekura ML et al (2001) Brain proton magnetic resonance spectroscopy in children exposed to methamphetamine in utero. Neurology 57:255–260. https://doi.org/10.1212/WNL.57.2.255 CrossRefPubMed

Smith SM, Jenkinson M, Woolrich MW et al (2004) Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage 23(Suppl 1):S208–S219. https://doi.org/10.1016/j.neuroimage.2004.07.051 CrossRefPubMed

Song S, Yoshino J, Le TQ et al (2005) Demyelination increases radial diffusivity in corpus callosum of mouse brain. NeuroImage 26:132–140. https://doi.org/10.1016/j.neuroimage.2005.01.028 CrossRefPubMed

Sowell ER, Leow AD, Bookheimer SY et al (2010) Differentiating prenatal exposure to methamphetamine and alcohol versus alcohol and not methamphetamine using tensor-based brain morphometry and discriminant analysis. J Neurosci 30:3876–3885. https://doi.org/10.1523/JNEUROSCI.4967-09.2010 CrossRefPubMedPubMedCentral

Stek AM, Baker RS, Fisher BK et al (1995) Fetal responses to maternal and fetal methamphetamine administration in sheep. Am J Obstet Gynecol 173:1592–1598CrossRefPubMed

Tanabe J, Tregellas JR, Dalwani M et al (2009) Medial orbitofrontal cortex gray matter is reduced in abstinent substance-dependent individuals. Biol Psychiatry 65:160–164. https://doi.org/10.1016/j.biopsych.2008.07.030 CrossRefPubMed

Tang CY, Friedman J, Shungu D et al (2007) Correlations between diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (1H MRS) in schizophrenic patients and normal controls. BMC Psychiatry 7:25. https://doi.org/10.1186/1471-244X-7-25 CrossRefPubMedPubMedCentral

Tavares MA, Silva MC, Silva-Araújo A et al (1996) Effects of prenatal exposure to amphetamine in the medial prefrontal cortex of the rat. Int J Dev Neurosci 14:585–596CrossRefPubMed

Taylor PA, Saad ZS (2013) FATCAT: (an efficient) functional and Tractographic connectivity analysis toolbox. Brain Connect 3:523–535. https://doi.org/10.1089/brain.2013.0154 CrossRefPubMedPubMedCentral

Taylor PA, Cho K, Lin C, Biswal BB (2012) Improving DTI tractography by including diagonal tract propagation. PLoS One 7:e43415. https://doi.org/10.1371/journal.pone.0043415 CrossRefPubMedPubMedCentral

Taylor PA, Jacobson SW, van der Kouwe A et al (2015) A DTI-based tractography study of effects on brain structure associated with prenatal alcohol exposure in newborns. Hum Brain Mapp 36:170–186. https://doi.org/10.1002/hbm.22620 CrossRefPubMed

Thompson PM, Hayashi KM, Simon SL et al (2004) Structural abnormalities in the brains of human subjects who use methamphetamine. J Neurosci 24:6028–6036. https://doi.org/10.1523/JNEUROSCI.0713-04.2004 CrossRefPubMed

Tobias MC, O’Neill J, Hudkins M et al (2010) White-matter abnormalities in brain during early abstinence from methamphetamine abuse. Psychopharmacology 209:13–24. https://doi.org/10.1007/s00213-009-1761-7 CrossRefPubMedPubMedCentral

UNODC (2017a) World drug report 2017. Market analysis of synthetic drugs. United Nations Office on Drugs and Crime. http://www.unodc.org/documents/scientific/Booklet_4_Market_Analysis_of_Synthetic_Drugs_ATS_NPS.pdf. Accessed 16 Oct 2017

UNODC (2017b) World drug report 2017. Global overview of drug demand and supply. United Nations Office on Drugs and Crime. https://www.unodc.org/wdr2017/field/Booklet_2_HEALTH.pdf. Accessed 16 Oct 2017

van der Kouwe AJW, Benner T, Salat DH, Fischl B (2008) Brain morphometry with multiecho MPRAGE. NeuroImage 40:559–569. https://doi.org/10.1016/j.neuroimage.2007.12.025 CrossRefPubMedPubMedCentral

Volkow ND, Fowler JS (2000) Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb Cortex 10:318–325. https://doi.org/10.1093/cercor/10.3.318 CrossRefPubMed

Volkow ND, Chang L, Wang GJ et al (2001) Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers. Am J Psychiatry 158:383–389. https://doi.org/10.1176/appi.ajp.158.3.383 CrossRefPubMed

Winer B (1971) Statistical principles in experimental design, 2nd edn. McGraw-Hill Publishing Co, Columbus

Wu Q, Butzkueven H, Gresle M et al (2007) MR diffusion changes correlate with ultra-structurally defined axonal degeneration in murine optic nerve. NeuroImage 37:1138–1147. https://doi.org/10.1016/j.neuroimage.2007.06.029 CrossRefPubMed

Wu Y-H, Gau SS-F, Lo Y-C, Tseng W-YI (2014) White matter tract integrity of frontostriatal circuit in attention deficit hyperactivity disorder: association with attention performance and symptoms. Hum Brain Mapp 35:199–212. https://doi.org/10.1002/hbm.22169 CrossRefPubMed

Titel: Prenatal methamphetamine exposure is associated with corticostriatal white matter changes in neonates
verfasst von: Fleur L. Warton
Paul A. Taylor
Christopher M. R. Warton
Christopher D. Molteno
Pia Wintermark
Nadine M. Lindinger
Lilla Zöllei
Andre van der Kouwe
Joseph L. Jacobson
Sandra W. Jacobson
Ernesta M. Meintjes
Publikationsdatum: 23.10.2017
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 2/2018
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-017-0135-9

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

25.04.2024 | Hypotonie | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Prenatal methamphetamine exposure is associated with corticostriatal white matter changes in neonates

Abstract

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Frühe Alzheimertherapie lohnt sich

Viel Bewegung in der Parkinsonforschung

Demenzkranke durch Antipsychotika vielfach gefährdet

Update Neurologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2018

Altered brain morphometry in 7-year old HIV-infected children on early ART

Moringa oleifera supplemented diet modulates nootropic-related biomolecules in the brain of STZ-induced diabetic rats treated with acarbose

Hypothalamic-pituitary-adrenal axis variants and childhood trauma influence anxiety sensitivity in South African adolescents

Fractional anisotropy of white matter, disability and blood iron parameters in multiple sclerosis

Curcumin-supplemented diets improve antioxidant enzymes and alter acetylcholinesterase genes expression level in Drosophila melanogaster model

Peromyscus maniculatus bairdii as a naturalistic mammalian model of obsessive-compulsive disorder: current status and future challenges

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Frühe Alzheimertherapie lohnt sich

Viel Bewegung in der Parkinsonforschung

Demenzkranke durch Antipsychotika vielfach gefährdet

Update Neurologie