Background
Methods
Search strategy
Study selection criteria
Data analyses
Results
Included studies
Author (year) | Objective | Participants | Intervention | Outcome | Note |
---|---|---|---|---|---|
Matsuo, J. et al. 2018 [35] | To assess PPI deficits in patients with BD stratified by gender and disease status (euthymic/depressed). | 106 BD (63 with depression and 43 euthymic; 26 BD I and 80 BD II) and 232 control subjects. | All individuals were evaluated using the computerized startle reflex test unit, lead Interval of prepulse-pulse is 60 ms and 120 ms. | The male BD patients with depression had significant PPI deficits, female BD patients with psychosis show lower PPI. | qualitative synthesis |
QJ, Bo. et al. 2018 [36] | Using a perceived PSS-PPI paradigm to assess PPI levels in patients with BD. | 30 non-manic patients with BD and 33 HC | PPI was evaluated using a modified PSS-PPI paradigm, lead Interval of prepulse-pulse is 120 ms | Patients with BD exhibited PPI deficit by using PSS-PPI paradigm. PSS-PPI deficits was significantly associated with the language domain of RBANS. | qualitative synthesis |
Sanchez-Morla, E. M. et al. 2016 [16] | To assess PPI level in euthymic patients with BD. | 64 euthymic patients with BD and 64 control subjects | The acoustic startle measures of PPI were performed using 60-ms and 120-ms lead interval. | Compared with HC, BD patients showed PPI deficits that is related to social cognition | qualitative/quantitative synthesis |
Tamminga, C. A. et al. 2014 [37] | To assess SPEM, PPI, and ERP between schizophrenia and BD | 26 psychotic bipolar I disorder and 22 HC were tested for PPI level. | Standard clinical characterization and PPI (lead Interval, 120 ms) paradigm were applied. | PPI level did not differ between psychotic bipolar I disorder and HC. | qualitative synthesis |
Gogos, A. et al. 2009 [26] | To explore gender difference in PPI level in patients with BD. | 29 euthymic patients with BD, and 32 HC. | Two PPI stimulus onset asynchrony levels (60, 120 ms) were assessed by 21 pulse-alone trials (115 dB) and a total of 42 prepulse-pulse trials. | Compared with controls, the male patients with BD showed reduced PPI, whereas female patients had increased PPI levels. | qualitative/quantitative synthesis |
Carroll, C. A. et al. 2007 [29] | To assess PPI level in manic and mixed episode BD. | 14 manic patients with BD, 21 mixed episode patients with BD and 32 HC. | The acoustic startle measures of PPI were performed using a 120-ms lead interval. | Compared to HC, mixed episode patients exhibited less PPI latency facilitation, but PPI deficits were not observed across diagnostic groups (manic, mixed, control) | qualitative synthesis |
Giakoumaki, S. G. et al. 2007 [20] | To assess PPI level in remitted patients with BD and their unaffected siblings. | 21 patients with BD, 19 unaffected siblings and 17 HC | The tests of acoustic startle reactivity and PPI (lead Interval, 60 ms and 120 ms) of the startle response were investigated. | Patients with BD and their unaffected siblings showed PPI deficits, and had no significant correlation with symptom and disease severity. | qualitative/quantitative synthesis |
Barrett, S. L. et al. 2005 [28] | To assess PPI level in the euthymic phase of BD. | 23 euthymic patients with BD, and 20 HC. | The tests of acoustic startle reactivity and PPI of the startle response were performed. Lead interval of prepulse-pulse is 60 ms and 120 ms | There was no significant PPI deficits in the euthymic phase of BD. | qualitative/quantitative synthesis |
Rich, B. A. et al. 2005 [30] | To investigate PPI level in pediatric BD. | 16 patients with BD (medicated, euthymic and nonpsychotic), and 13 HC. | The magnitude of startle habituation, startle-alone response, and inhibition of startle following a 60 or 120-ms prepulse were evaluated. | Pediatric BD patients did not show PPI deficits compared to healthy controls. | qualitative/quantitative synthesis |
Braff, D. L. et al. 2001 [27] | To explore PPI level in BD patients with acute psychotic mania. | 15 patients with BD, 16 patients with schizophrenia and 17 HC | PPI (60 ms and 120 ms interstimulus intervals) was measured using Xeye Human startle reflex system. | Compared with HC, BD patients with acute psychotic mania had PPI deficits, and the extent of deficits was not significantly different from schizophrenia | qualitative synthesis |
Meta analyses
Author (year) | Sample (N) | Male (%) | Age (year) | Smokers (%) | Stages of disease | Psychosis History | medications | Patients clinical characteristics | Experimental paradigm | Getdata |
---|---|---|---|---|---|---|---|---|---|---|
Sanchez-Morla, E. M. et al. 2016 [16] | BD I (52) | 22 (42.3) | 42.6 (11.0) | 18 (34.6) | Euthymic (HAMD < 7, YMRS < 6, for at least the previous 3 months) | NA | 59.6% SGA, 50% Lithium, 48.1% Anticonvulsants, 30.8% Antidepressants, 30.8% Benzodiazepines | YMRS < 6 HAMD < 7 | Background noise 70 dB Pulse 40 ms 118 dB Prepulse 20 ms 80 dB Interval 60 and 120 ms | No |
HC (50) | 23 (46) | 39.3 (10.1) | 17 (34.0) | |||||||
Gogos, A. et al. 2009 [26] | BD (29) | 14 (48.3) | 42.9 (10.9) | 9 (31.0) | Euthymic (Self-reported Euthymic) | NA | 51.7% Antipsychotics,48.3% Sodium valproate, 24.1% Lithium, 37.9% Antidepressants | MRS 2.5 ± 3.7 HAMD 7.0 ± 6.3 PANSS 44 ± 9.5 | Background noise 70 dB Pulse 40 ms 115 dB Prepulse 20 ms 74,78 and 86 dB Interval 60 and 120 ms | Yes |
HC (32) | 16 (50) | 40.5 (11.7) | 1 (3.1) | |||||||
HC (32) | 15 (46.9) | 30.4 (8.5) | NA | |||||||
Giakoumaki, S. G. et al. 2007 [20] | BD I (21) | 11 (52.4) | 32.9 (7.3) | NA | Euthymic (HAMD < 7, YMRS < 7) | N = 10 | 71.42% Antipsychotic Medication 28.57% Lithium 23.8% Valproate, 52.38% Carbamazepine | YMRS 3.29 ± 2.28 HAMD 3.43 ± 2.48, BPRS 27.00 ± 5.18, GAF 72.71 ± 9.83 | Background noise 70 dB Pulse 40 ms 115 dB Prepulse 20 ms 85 dB Interval 60 and 120 ms | Yes |
HC (17) | 10 (58.8) | 31.6 (6.9) | NA | |||||||
Barrett, S. L. et al. 2005 [28] | BD (23) | 12 (52.17) | 46.4 (13.4) | 10 (43.47) | Euthymic (HAMD < 8, YMRS < 20) | NA | 26.09% Antipsychotics, 26.09% Sodium valproate, 78.26% Lithium 21.74% Antidepressants 8.70% Carbamazepine | YMRS 1.9 ± 3.1 HAMD 3.0 ± 2.0 | Background noise 70 dB Pulse 40 ms 111 dB Prepulse 40 ms 70 and 85 dB Interval 60 or 120 ms | Yes |
HC (20) | 10 (50) | 42.4 (13.0) | 2 (10) | |||||||
Rich, B. A. et al. 2005 [30] | BD (16) | 7 (53.8) | 12.7 (2.7) | NA | Euthymic (16 subjects were in euthymic period, no clear definition) | No | 68.8% antipsychotics, 68.8% anticonvulsants 50.0% antidepressants, 43.8% lithium 25.0% stimulants, 25.0% sedatives | YMRS 3.71 ± 6.20 CDRS 23.14 ± 6.16, K-SADS psychosis score 2.00 ± 0.00 | Background noise NA Pulse NA 104 dB Prepulse 50 ms 70 dB Interval 60 or 120 ms | Yes |
HC (13) | 7 (43.8) | 13.2 (2.2) | NA |
Quality assessments
The Case Definition | Representativeness of the Cases | Selection of Controls | Definition of Controls | Comparability(a) | Comparability (b) | Exposure (1) | Exposure (2) | Exposure (3)a | |
---|---|---|---|---|---|---|---|---|---|
Sanchez-Morla, E. M. et al. 2016 | * | * | * | * | * | * | * | ||
Gogos, A. et al. 2009 | * | * | * | * | * | * | * | * | |
Giakoumaki, S. G. et al. 2007 | * | * | * | * | * | * | * | * | |
Barrett, S. L. et al. 2005 | * | * | * | * | * | * | * | * | |
Rich, B. A. et al. 2005 | * | * | * | * | * | * |