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Archives of Virology

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01.12.2011 | Brief Report

Presence of a full-length highly polymorphic region (HPR) in the ISAV haemagglutinin-esterase does not affect the primary functions of receptor binding and esterase activity

verfasst von: Alastair McBeath, Mickael Fourrier, Eann Munro, Knut Falk, Mike Snow

Erschienen in: Archives of Virology | Ausgabe 12/2011

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Abstract

The putatively avirulent infectious salmon anaemia virus (ISAV) HPR0 variant has key phenotypic differences to isolates from disease outbreaks in Atlantic salmon farms. It appears to not cause disease, potentially displays a different tissue tropism and has yet to be isolated in conventional ISAV-permissive cell lines. This study focussed on identifying the biological basis for the observed differences by examining the properties of the haemagglutinin-esterase (HE) proteins derived from NWM10 (HPR0), Nevis 390/98 (HPR7 pathogenic strain) and mutant combinations of the two. Using a transfection-based system and haemadsorption analysis in salmon cell lines, this study demonstrated for the first time that an HPR0 HE was fully functional in terms of receptor-binding and -destroying activity and also suggested that the presence of a full-length HPR alone did not appear to affect these functions.

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Titel: Presence of a full-length highly polymorphic region (HPR) in the ISAV haemagglutinin-esterase does not affect the primary functions of receptor binding and esterase activity
verfasst von: Alastair McBeath
Mickael Fourrier
Eann Munro
Knut Falk
Mike Snow
Publikationsdatum: 01.12.2011
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 12/2011
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-011-1106-9

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