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17.04.2023 | Gynecologic Endocrinology and Reproductive Medicine

Presence of endometrioma decreased blastocyst formation rate but not impair Assisted Reproductive Technology (ART) outcome

verfasst von: Jui-Chun Chang, Yu-Chiao Yi, Ya-Fang Chen, Hwa-Fen Guu, Hsiao-Fan Kung, Li-Yu Chen, Shih-Ting Chuan, Ming-Jer Chen

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 6/2023

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Abstract

Purpose

This study aims to assess the impact of endometrioma on patients who undergo ART treatment due to endometriosis.

Methods

A retrospective study was conducted on women ≤ 40 years of age who underwent ART treatment at an academic medical center between January 2014 and December 2020. Two-hundred-and-eight women had received IVF/ICSI treatment due to endometriosis and there were 89 patients presence of endometrioma. Patients were further divided into primary endometrioma, recurrent endometrioma and those having received cystectomy for endometrioma prior to IVF/ICSI. The control group included 624 infertile women without endometriosis.

Results

In the endometrioma subgroup (B) the blastocyst formation rate was significantly lower when compared with the endometriosis (A) and control groups (C). The cumulative live birth rates (CLBRs) (60.5% versus 49.4% versus 56.9%, p = 0.194 in A versus B, p = 0.406 in A versus C, p = 0.878 in B versus C) were comparable. Multiple logistic regression analysis revealed that female age, total FSH dose and blastocyst formation rate were the significant variables in predicting CLBR (OR 0.89, CI 0.80–0.99, p < 0.025, OR 0.68 CI 0.53–0.88, p = 0.003 and OR 30.04, CI 9.93–90.9, p < 0.001, respectively). The CLBRs were comparable at 47.1%, 60% and 57.9% in the primary endometrioma, s/p cystectomy and recurrent endometrioma group.

Conclusion

Although the blastocyst formation rate was lower in the endometrioma group, CLBR was not worse than those who were in the endometriosis or control group. Cystectomy for endometrioma did not alter IVF/ICSI outcomes if the ovarian reserve was comparable. Recurrent endometrioma did not worsen IVF/ICSI outcomes than primary endometrioma.

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Titel: Presence of endometrioma decreased blastocyst formation rate but not impair Assisted Reproductive Technology (ART) outcome
verfasst von: Jui-Chun Chang
Yu-Chiao Yi
Ya-Fang Chen
Hwa-Fen Guu
Hsiao-Fan Kung
Li-Yu Chen
Shih-Ting Chuan
Ming-Jer Chen
Publikationsdatum: 17.04.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 6/2023
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-023-07036-2

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Presence of endometrioma decreased blastocyst formation rate but not impair Assisted Reproductive Technology (ART) outcome