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28.10.2021 | Original Article

Prevalence of cognitive dysfunction and its risk factors in children with chronic kidney disease in a developing country

verfasst von: Elawin Viriyapak, Sasitorn Chantaratin, Kanokwan Sommai, Achra Sumboonnanonda, Anirut Pattaragarn, Suroj Supavekin, Nuntawan Piyaphanee, Kraisoon Lomjansook, Thanaporn Chaiyapak

Erschienen in: Pediatric Nephrology | Ausgabe 6/2022

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Abstract

Background

Chronic kidney disease (CKD) is associated with cognitive dysfunction. Cognitive function in children with CKD residing in developing countries has not been previously reported.

Methods

This cross-sectional study included children aged 6–18 years with CKD stages 2–5D and kidney transplant. Cognitive function was assessed by WISC-V for children from 6–16 years of age. In adolescents 17–18 years of age, WAIS-III was used. Factors associated with cognitive dysfunction were identified using multivariable regression analysis.

Results

Thirty-seven children with median age 13.9 (11.3–15.7) years were recruited. The median full-scale intelligence quotient (FSIQ) was 83.0 (71.0–95.0). Below-average cognitive function (FSIQ <90) was identified in 24 children (64.8%), 24.3% of whom had cognitive impairment (FSIQ <70). Most children (94.6%) scored lower than average on at least 1 cognitive domain. Kidney replacement therapy (p = 0.03) and low family income (p = 0.02) were associated with below-average cognitive function in multivariable logistic regression analysis. Children who left school and low family income were significantly associated with cognitive function. The FSIQ of children who had left school was 12.94 points lower than the educated group (p = 0.046). In addition, every 10,000 Thai Baht (approximately 330 United States dollars) increase in family income correlated with 1.58 increase in FSIQ (p = 0.047).

Conclusion

Cognitive dysfunction was commonly found in children with CKD. Socioeconomic factors, particularly school attendance and family income, were associated with cognitive dysfunction. Cognitive evaluation is suggested for children with CKD who have socioeconomic risk factors.

Graphical abstract

“A higher resolution version of the Graphical abstract is available as Supplementary information.”

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Titel: Prevalence of cognitive dysfunction and its risk factors in children with chronic kidney disease in a developing country
verfasst von: Elawin Viriyapak
Sasitorn Chantaratin
Kanokwan Sommai
Achra Sumboonnanonda
Anirut Pattaragarn
Suroj Supavekin
Nuntawan Piyaphanee
Kraisoon Lomjansook
Thanaporn Chaiyapak
Publikationsdatum: 28.10.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 6/2022
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-021-05280-9

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Springer Medizin

Prevalence of cognitive dysfunction and its risk factors in children with chronic kidney disease in a developing country

Abstract

Background

Methods

Results

Conclusion

Graphical abstract

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Background

Methods

Results

Conclusion

Graphical abstract

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