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European Child & Adolescent Psychiatry
Erschienen in: European Child & Adolescent Psychiatry 7/2006

01.10.2006 | ORIGINAL CONTRIBUTION

Prevalence of movement disorders in adolescent patients with schizophrenia and in relationship to predominantly atypical antipsychotic treatment

verfasst von: Stefan Gebhardt, MD, Fabian Härtling, MD, Markus Hanke, Markus Mittendorf, Frank M. Theisen, MD, Karin Wolf-Ostermann, Phillip Grant, Matthias Martin, MD, Christian Fleischhaker, MD, Eberhard Schulz, MD, Helmut Remschmidt, MD, PhD

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 7/2006

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Abstract

Objective

To examine prevalence of movement disorders (MDs) such as tardive dyskinesia (TD), parkinsonism or akathisia in an adolescent population with schizophrenia and in relationship to predominantly atypical antipsychotic treatment.

Method

Ninety-three patients (aged 19.6±2.2 years) were ascertained in this cross-sectional/retrospective study. 76 patients (81.7%) received atypical, 10 (10.8%) typical antipsychotics and 7 (7.5%) combinations of atypical/typical antipsychotics. MD symptoms were assessed using Tardive Dyskinesia Rating Scale (TDRS), Abnormal Involuntary Movement Scale (AIMS), Extrapyramidal Symptom Scale (EPS), Barnes Akathisia Scale (BAS).

Results

Movement disorder symptoms were found in 37 patients (39.8%) fulfilling strict/subthreshold criteria for TD (5.4/11.8%), parkinsonism (2.2/25.8%) or akathisia (1.1/11.8%), respectively. Patients treated with typical antipsychotics displayed a significantly higher EPS-score (P=0.036) and a tendency towards a higher BAS-score (P=0.061) compared to patients with atypical antipsychotics. Treatment durations with typical/atypical antipsychotics showed trends towards advantages of atypical antipsychotics with regard to parkinsonism/akathisia symptoms (P=0.061; P=0.054), but not with regard to TD symptoms (P=0.003), possibly due to confounding effects.

Conclusion

Under treatment with atypical antipsychotics MD symptoms are less prevalent and less pronounced than under typical antipsychotics. We speculate that the finding of relatively high prevalence rates of subthreshold MD symptoms may be, at least partially, explained by previous or combined therapy with typical antipsychotics.
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Metadaten
Titel
Prevalence of movement disorders in adolescent patients with schizophrenia and in relationship to predominantly atypical antipsychotic treatment
verfasst von
Stefan Gebhardt, MD
Fabian Härtling, MD
Markus Hanke
Markus Mittendorf
Frank M. Theisen, MD
Karin Wolf-Ostermann
Phillip Grant
Matthias Martin, MD
Christian Fleischhaker, MD
Eberhard Schulz, MD
Helmut Remschmidt, MD, PhD
Publikationsdatum
01.10.2006
Erschienen in
European Child & Adolescent Psychiatry / Ausgabe 7/2006
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-006-0544-5

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European Child & Adolescent Psychiatry 7/2006 Zur Ausgabe

ORIGINAL CONTRIBUTION

Impaired working speed and executive functions as frontal lobe dysfunctions in young first-degree relatives of schizophrenic patients

ORIGINAL CONTRIBUTION

Ethnic differences in parental detection of externalizing disorders

ORIGINAL CONTRIBUTION

The effect of birth-weight with genetic susceptibility on depressive symptoms in childhood and adolescence

ORIGINAL CONTRIBUTION

The continuity of psychopathology from early childhood to preadolescence

ORIGINAL CONTRIBUTION

Children aged 4–8 years treated with parent training and child therapy because of conduct problems: generalisation effects to day-care and school settings

ORIGINAL CONTRIBUTION

Suicide in Austrian children and young adolescents aged 14 and younger

Neu im Fachgebiet Psychiatrie

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

23.04.2024 Depression antepartal oder postpartal Nachrichten

Bislang gibt es kein Medikament zur Prävention von Wochenbettdepressionen. Das Injektionsanästhetikum Esketamin könnte womöglich diese Lücke füllen.

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

22.04.2024 DGIM 2024 Kongressbericht

Die Kombination aus Medikamenten und Psychotherapie gilt als effektivster Ansatz bei Depressionen. Das ist bei betagten Menschen nicht anders, trotz Besonderheiten.

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

22.04.2024 DGIM 2024 Nachrichten

Um Menschen nach der Flucht aus einem Krisengebiet bestmöglich medizinisch betreuen zu können, ist es gut zu wissen, welche Erkrankungen im jeweiligen Herkunftsland häufig sind. Dabei hilft eine Internetseite der CDC (Centers for Disease Control and Prevention).

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