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13.10.2018 | Original Article

Prevalence of vitamin B₁₂ deficiency in South Indians with different grades of glucose tolerance

verfasst von: Ramamoorthy Jayashri, Ulagamathesan Venkatesan, Menon Rohan, Kuppan Gokulakrishnan, Coimbatore Subramanian Shanthi Rani, Mohan Deepa, Ranjit Mohan Anjana, Viswanathan Mohan, Rajendra Pradeepa

Erschienen in: Acta Diabetologica | Ausgabe 12/2018

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Abstract

Aims

To determine the prevalence of vitamin B₁₂ deficiency in an urban south Indian population in individuals with different grades of glucose tolerance.

Methods

A total of 1500 individuals [900 normal glucose tolerance (NGT), 300 prediabetes and 300 type 2 diabetes (T2DM)] who were not on vitamin B₁₂ supplementation were randomly selected from the Chennai Urban Rural Epidemiological Study (CURES) follow-up study. Anthropometric, clinical and biochemical investigations, which included vitamin B₁₂, insulin, homocysteine, HbA1c and serum lipids, were measured. Vitamin B₁₂ ≤ 191 pg/ml was defined as absolute vitamin B₁₂ deficiency and vitamin B₁₂ > 191 pg/ml and ≤ 350 pg/ml as borderline deficiency.

Results

The mean levels of vitamin B₁₂ significantly decreased with increasing degrees of glucose tolerance (NGT 444 ± 368; prediabetes 409 ± 246; T2DM 389 ± 211 pg/ml, p = 0.021). The prevalence of absolute vitamin B₁₂ deficiency was 14.9% while 37.6% had borderline deficiency. The prevalence of absolute vitamin B₁₂ deficiency was significantly higher among individuals with T2DM (18.7%) followed by prediabetes (15%) and NGT(13.7%) [p for trend = 0.05]. The prevalence of vitamin B₁₂ significantly increased with age (p < 0.05) and in those with abdominal obesity (p < 0.001). Men and vegetarians had twice the risk of vitamin B₁₂ deficiency compared to women and non-vegetarians, respectively. Among individuals with NGT, prediabetes and T2DM, vitamin B₁₂ negatively correlated with homocysteine.

Conclusion

This study reports that the levels of vitamin B₁₂ decreased with increasing severity of glucose tolerance.

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Titel: Prevalence of vitamin B12 deficiency in South Indians with different grades of glucose tolerance
verfasst von: Ramamoorthy Jayashri
Ulagamathesan Venkatesan
Menon Rohan
Kuppan Gokulakrishnan
Coimbatore Subramanian Shanthi Rani
Mohan Deepa
Ranjit Mohan Anjana
Viswanathan Mohan
Rajendra Pradeepa
Publikationsdatum: 13.10.2018
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 12/2018
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-018-1240-x

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