Primary cutaneous CD30+ lymphoproliferative disorders with DUSP22 translocation
- 27.11.2023
- Hauptreferate: Hauptprogramm der DGP
Erschienen in:
- Verfasst von
- Santiago Montes-Moreno, MD, PhD
- Erschienen in
- Die Pathologie | Sonderheft 3/2023
Abstract
Primary cutaneous CD30+ lymphoproliferative disorders (LPD) encompass a broad category of clonal T cell proliferations with varied clinical presentations. Classically, lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (ALCL) have been recognized as distinct clinicopathological entities according to their differing clinical features. Recently, a subset of LyP and both cutaneous and systemic ALCL have been shown to carry a DUSP22 translocation [1‐3], a defining molecular feature for the novel entity “LyP with DUSP22t” [1]. In cutaneous biopsies, both primary cutaneous DUSP22-translocated ALCL and LyP with DUSP22 rearrangements are characterized by a biphasic pattern with significant small cell epidermotropism. A distinct protein expression profile with preserved T Cell Receptor (TCR) expression, positivity for CD30, LEF1, HLA, and CD58, and negativity for cytotoxic marker expression as well as phospho-STAT3 protein is consistently found in these cases.
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- Titel
- Primary cutaneous CD30+ lymphoproliferative disorders with DUSP22 translocation
- Verfasst von
-
Santiago Montes-Moreno, MD, PhD
- Publikationsdatum
- 27.11.2023
- Verlag
- Springer Medizin
- Erschienen in
-
Die Pathologie / Ausgabe Sonderheft 3/2023
Print ISSN: 2731-7188
Elektronische ISSN: 2731-7196 - DOI
- https://doi.org/10.1007/s00292-023-01258-6
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