nach oben

European Journal of Nutrition

Erschienen in:

01.02.2013 | Original Contribution

Principal component 1 score calculated from metabolic syndrome diagnostic parameters is a possible marker for the development of metabolic syndrome in middle-aged Japanese men without treatment for metabolic diseases

verfasst von: Kazuki Mochizuki, Rie Miyauchi, Yasumi Misaki, Yoko Ichikawa, Toshinao Goda

Erschienen in: European Journal of Nutrition | Ausgabe 1/2013

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The risk of metabolic syndrome (MetS) is assessed based on the presence of risk factors that include dyslipidemia, hyperglycemia, hypertension and obesity. In this study, we assessed the risk of MetS using principle component (PC) analysis of MetS diagnostic parameters and examined whether the resulting eigenvalues are associated with the circulating concentrations of inflammatory cytokines [interleukin (IL)-1β and IL-6] and a marker for insulin sensitivity (adiponectin) in middle-aged Japanese men without treatment for metabolic diseases.

Materials

We conducted a cross-sectional study of 308 Japanese men without treatment for metabolic diseases aged 40–69 years who participated in health checkups in Japan. We calculated the PC1 score from the following MetS diagnostic parameters: body mass index (BMI), fasting blood glucose, diastolic blood pressure, triacylglycerol and high-density lipoprotein cholesterol. We compared the relationship between PC1 scores and other clinical parameters, including IL-1β, IL-6 and adiponectin, by Spearman’s rank correlation coefficient analyses and Jonckheere–Terpstra test.

Results

The associations for most clinical parameters were higher with the PC1 score than with other MetS diagnostic parameters. Homeostasis model assessment–insulin resistance, an index of insulin resistance, showed stronger associations with PC1 score than with MetS diagnostic parameters. Significant associations for IL-1β, IL-6 and adiponectin were observed with the PC1 score, BMI and triacylglycerol; these associations were higher with the PC1 score than with BMI and triacylglycerol.

Conclusions

The present results show that the PC1 score is closely associated with parameters of MetS, inflammation and insulin resistance.

Vettor R, Milan G, Rossato M, Federspil G (2005) Review article: adipocytokines and insulin resistance. Aliment Pharmacol Ther 22(suppl 2):3–10CrossRef

Brownlee M (2001) Biochemistry and molecular cell biology of diabetic complications. Nature 414(6865):813–820CrossRef

Ceriello A, Motz E (2004) Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 24(5):816–823CrossRef

Wajchenberg BL (2000) Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 21(6):697–738CrossRef

Perrini S, Leonardini A, Laviola L, Giorgino F (2008) Biological specificity of visceral adipose tissue and therapeutic intervention. Arch Physiol Biochem 114(4):277–286CrossRef

Smith SC Jr (2007) Multiple risk factors for cardiovascular disease and diabetes mellitus. Am J Med 120(3 suppl 1):S3–S11CrossRef

Kokubo Y, Kamide K (2009) High-normal blood pressure and the risk of cardiovascular disease. Circ J 73(8):1381–1385CrossRef

Doi Y, Ninomiya T, Hata J, Fukuhara M, Yonemoto K, Iwase M, Iida M, Kiyohara Y (2010) Impact of glucose tolerance status on development of ischemic stroke and coronary heart disease in a general Japanese population The Hisayama study. Stroke 41(2):203–209

Choo KE, Lau KB, Davis WA, Chew PH, Jenkins AJ, Davis TM (2007) Cardiovascular risk factors in pre-pubertal Malays: effects of diabetic parentage. Diabetes Res Clin Pract 76(1):119–125CrossRef

10.

Anderson PJ, Critchley JA, Chan JC, Cockram CS, Lee ZS, Thomas GN, Tomlinson B (2001) Factor analysis of the metabolic syndrome: obesity vs. insulin resistance as the central abnormality. Int J Obes Relat Metab Disord 25(12):1782–1788CrossRef

11.

Hanley AJ, Karter AJ, Festa A, D’Agostino R Jr, Wagenknecht LE, Savage P, Tracy RP, Saad MF, Haffner S (2002) Factor analysis of metabolic syndrome using directly measured insulin sensitivity: the insulin resistance atherosclerosis study. Diabetes 51(8):2642–2647CrossRef

12.

Esteghamati A, Zandieh A, Khalilzadeh O, Meysamie A, Ashraf H (2010) Clustering of metabolic syndrome components in a Middle Eastern diabetic and non-diabetic population. Diabetol Metab Syndr 2:36

13.

Spranger J, Kroke A, Mohlig M, Hoffmann K, Bergmann MM, Ristow M, Boeing H, Pfeiffer AF (2003) Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European prospective investigation into cancer and nutrition (EPIC)-potsdam study. Diabetes 52(3):812–817CrossRef

14.

Kim ES, Im JA, Kim KC, Park JH, Suh SH, Kang ES, Kim SH, Jekal Y, Lee CW, Yoon YJ, Lee HC, Jeon JY (2007) Improved insulin sensitivity and adiponectin level after exercise training in obese Korean youth. Obesity (Silver Spring) 15(12):3023–3030CrossRef

15.

Bruun JM, Stallknecht B, Helge JW, Richelsen B (2007) Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss. Eur J Endocrinol 157(4):465–471CrossRef

16.

Hoge M, Amar S (2006) Role of interleukin-1 in bacterial atherogenesis. Drugs Today (Barc) 42(10):683–688CrossRef

17.

Mahmoudi M, Curzen N, Gallagher PJ (2007) Atherogenesis: the role of inflammation and infection. Histopathology 50(5):535–546CrossRef

18.

Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V (2000) Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 148(2):209–214CrossRef

19.

Deepa R, Velmurugan K, Arvind K, Sivaram P, Sientay C, Uday S, Mohan V (2006) Serum levels of interleukin 6, C-reactive protein, vascular cell adhesion molecule 1, and monocyte chemotactic protein 1 in relation to insulin resistance and glucose intolerance—The Chennai Urban Rural Epidemiology Study (CURES). Metabolism 55(9):1232–1238CrossRef

20.

Matsushita K, Yatsuya H, Tamakoshi K, Wada K, Otsuka R, Takefuji S, Sugiura K, Kondo T, Murohara T, Toyoshima H (2006) Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men. Arterioscler Thromb Vasc Biol 26(4):871–876CrossRef

21.

Misaki Y, Miyauchi R, Mochizuki K, Takabe S, Shimada M, Ichikawa Y, Goda T (2010) Plasma IL-1β concentrations are closely associated with fasting blood glucose levels in healthy and preclinical middle-aged, non-overweight and overweight Japanese men. Metabolism 59(10):1465–1471CrossRef

22.

Bastard JP, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M, Vidal H, Hainque B (2000) Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 85(9):3338–3342CrossRef

23.

Lin Y, Berg AH, Iyengar P, Lam TK, Giacca A, Combs TP, Rajala MW, Du X, Rollman B, Li W, Hawkins M, Barzilai N, Rhodes CJ, Fantus IG, Brownlee M, Scherer PE (2005) The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem 280(6):4617–4626CrossRef

24.

Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T (2002) Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8(11):1288–1295CrossRef

25.

Shetty GK, Economides PA, Horton ES, Mantzoros CS, Veves A (2004) Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes. Diabetes Care 27(10):2450–2457CrossRef

26.

Gottsater A, Szelag B, Kangro M, Wroblewski M, Sundkvist G (2004) Plasma adiponectin and serum advanced glycated end-products increase and plasma lipid concentrations decrease with increasing duration of type 2 diabetes. Eur J Endocrinol 151(3):361–366CrossRef

27.

Mannucci E, Ognibene A, Cremasco F, Dicembrini I, Bardini G, Brogi M, Terreni A, Caldini A, Messeri G, Rotella CM (2003) Plasma adiponectin and hyperglycaemia in diabetic patients. Clin Chem Lab Med 41(9):1131–1135CrossRef

28.

Chandran M, Phillips SA, Ciaraldi T, Henry RR (2003) Adiponectin: more than just another fat cell hormone? Diabetes Care 26(8):2442–2450CrossRef

29.

Sakuta H, Suzuki T, Yasuda H, Ito T (2005) Adiponectin levels and cardiovascular risk factors in Japanese men with type 2 diabetes. Endocr J 52(2):241–244CrossRef

30.

Jaleel F, Jaleel A, Aftab J, Rahman MA (2006) Relationship between adiponectin, glycemic control and blood lipids in diabetic type 2 postmenopausal women with and without complication of ischemic heart disease. Clin Chim Acta 370(1–2):76–81CrossRef

31.

Suzuki T, Katz R, Jenny NS, Zakai NA, LeWinter MM, Barzilay JI, Cushman M (2008) Metabolic syndrome, inflammation, and incident heart failure in the elderly: the cardiovascular health study. Circ Heart Fail 1(4):242–248CrossRef

32.

Ley SH, Harris SB, Connelly PW, Mamakeesick M, Gittelsohn J, Hegele RA, Retnakaran R, Zinman B, Hanley AJ (2008) Adipokines and incident type 2 diabetes in an Aboriginal Canadian [corrected] population: the Sandy Lake Health and Diabetes Project. Diabetes Care 31(7):1410–1415CrossRef

33.

Taniguchi A, Fukushima M, Ohya M, Nakai Y, Yoshii S, Nagasaka S, Matsumoto K, Taki Y, Kuroe A, Nishimura F, Seino Y (2006) Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patients. Metabolism 55(2):258–262CrossRef

34.

Higashiyama A, Okamura T, Ono Y, Watanabe M, Kokubo Y, Okayama A (2009) Risk of smoking and metabolic syndrome for incidence of cardiovascular disease—Comparison of relative contribution in urban Japanese population: the Suita study. Circ J 73(12):2258–2263CrossRef

35.

Kadota A, Miura K, Okamura T, Hozawa A, Murakami Y, Fujiyoshi A, Takashima N, Hayakawa T, Kita Y, Okayama A, Nakamura Y, Ueshima H (2011) Relationship of moderate metabolic risk factor clustering to cardiovascular disease mortality in non-lean Japanese: a 15-year follow-up of NIPPON DATA90. Atherosclerosis 215(1):209–213CrossRef

36.

Sone H, Mizuno S, Fujii H, Yoshimura Y, Yamasaki Y, Ishibashi S, Katayama S, Saito Y, Ito H, Ohashi Y, Akanuma Y, Yamada N (2005) Is the diagnosis of metabolic syndrome useful for predicting cardiovascular disease in Asian diabetic patients? Analysis from the Japan Diabetes Complications Study. Diabetes Care 28(6):1463–1471CrossRef

37.

Suzuki A, Kosuge K, Nanyu O, Watanabe H, Watanabe T, Usuda Y, Sasaki S, Aizawa Y (2010) Five year study of cardiovascular risk factors in Japanese people: implications concerning new onset of metabolic syndrome. Intern Med 49(1):1–6CrossRef

38.

Doi Y, Ninomiya T, Hata J, Yonemoto K, Arima H, Kubo M, Tanizaki Y, Iwase M, Iida M, Kiyohara Y (2009) Proposed criteria for metabolic syndrome in Japanese based on prospective evidence: the Hisayama study. Stroke 40(4):1187–1194CrossRef

39.

Nakanishi N, Takatorige T, Fukuda H, Shirai K, Li W, Okamoto M, Yoshida H, Matsuo Y, Suzuki K, Tatara K (2004) Components of the metabolic syndrome as predictors of cardiovascular disease and type 2 diabetes in middle-aged Japanese men. Diabetes Res Clin Pract 64(1):59–70CrossRef

Titel: Principal component 1 score calculated from metabolic syndrome diagnostic parameters is a possible marker for the development of metabolic syndrome in middle-aged Japanese men without treatment for metabolic diseases
verfasst von: Kazuki Mochizuki
Rie Miyauchi
Yasumi Misaki
Yoko Ichikawa
Toshinao Goda
Publikationsdatum: 01.02.2013
Verlag: Springer-Verlag
Erschienen in: European Journal of Nutrition / Ausgabe 1/2013
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-011-0287-z

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Purpose

Materials

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2013

Suboptimal maternal vitamin D status and low education level as determinants of small-for-gestational-age birth weight

Proteomic study of granulocytic differentiation induced by apigenin 7-glucoside in human promyelocytic leukemia HL-60 cells

Consumption of red meat and whole-grain bread in relation to biomarkers of obesity, inflammation, glucose metabolism and oxidative stress

Cardioprotective and hepatoprotective effects of ellagitannins from European oak bark (Quercus petraea L.) extract in rats

Accuracy and measures of association of anthropometric indexes of obesity to identify the presence of hypertension in adults: a population-based study in Southern Brazil