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01.12.2013 | Original Paper | Ausgabe 12/2013

Journal of Cancer Research and Clinical Oncology 12/2013

Prognostic nutritional index predicts outcomes of malignant pleural mesothelioma

Zeitschrift:
Journal of Cancer Research and Clinical Oncology > Ausgabe 12/2013
Autoren:
Zhou-Hong Yao, Guang-Yan Tian, Yun-Yan Wan, Yan-Meng Kang, Hai-Sheng Guo, Qing-Hua Liu, Dian-Jie Lin

Abstract

Purpose

Nutritional status has been associated with long-time outcomes in cancer patients. We investigated whether the prognostic nutritional index (PNI), an indicator of nutritional status, affects overall survival in patients with malignant pleural mesothelioma (MPM).

Methods

We enrolled 121 patients with histologically confirmed MPM, who had successfully undergone biopsy by medical thoracoscopy in this study. Demographic, clinical and laboratory data were collected retrospectively. The PNI was calculated as 10× serum albumin value (g/dl) + 0.005 × total lymphocyte count (per mm3) in peripheral blood. Univariate and multivariate analyses were used to identify prognostic factors.

Results

Mean pretreatment PNI was 44.6. PNI was significantly associated with age (P = 0.031), smoking habits (P = 0.039) and weight loss (P = 0.029). Survival analysis showed PNI to be an independent prognostic factor in MPM. Patients with lower PNIs (PNI < 44.6) had greater risk of death than those with higher PNIs (PNI ≥ 44.6; hazard ratio: 2.290; 95 % confidence interval: 1.415–3.706; P = 0.001). These analyses were adjusted for patient age, gender, smoking habits, dyspnea, chest pain, weight loss, primary site of tumor, histology, platinum-based systemic chemotherapy, hospital and stage.

Conclusions

Pretreatment PNI is a novel independent prognostic factor in MPM.

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