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17.10.2016 | Gastrointestinal

Prognostic significance of contrast-enhanced CT attenuation value in extrahepatic cholangiocarcinoma

verfasst von: Yoshiki Asayama, Akihiro Nishie, Kousei Ishigami, Yasuhiro Ushijima, Yukihisa Takayama, Daisuke Okamoto, Nobuhiro Fujita, Takao Ohtsuka, Tomoharu Yoshizumi, Shinichi Aishima, Yoshinao Oda, Hiroshi Honda

Erschienen in: European Radiology | Ausgabe 6/2017

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Abstract

Objectives

To determine whether washout characteristics of dynamic contrast-enhanced computed tomography (CT) could predict survival in patients with extrahepatic cholangiocarcinoma (EHC).

Methods

This study collected 46 resected cases. All cases were examined by dynamic contrast study on multidetector-row CT. Region-of-interest measurements were obtained at the non-enhanced, portal venous phase and delayed phase in the tumour and were used to calculate the washout ratio as follows: [(attenuation value at portal venous phase CT − attenuation value at delayed enhanced CT)/(attenuation value at portal venous phase CT − attenuation value at unenhanced CT)] × 100. On the basis of the median washout ratio, we classified the cases into two groups, a high-washout group and low-washout group. Associations between overall survival and various factors including washout rates were analysed.

Results

The median washout ratio was 29.4 %. Univariate analysis revealed that a lower washout ratio, venous invasion, lymphatic permeation and lymph node metastasis were associated with shorter survival. Multivariate analysis identified the lower washout ratio as an independent prognostic factor (hazard ratio, 3.768; p value, 0.027).

Conclusions

The washout ratio obtained from the contrast-enhanced CT may be a useful imaging biomarker for the prediction of survival of patients with EHC.

Key points

• Dynamic contrast study can evaluate the aggressiveness of extrahepatic cholangiocarcinoma.

• A lower washout ratio was an independent prognostic factor for overall survival.

• CT can predict survival and inform decisions on surgical options or chemotherapy.

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Titel: Prognostic significance of contrast-enhanced CT attenuation value in extrahepatic cholangiocarcinoma
verfasst von: Yoshiki Asayama
Akihiro Nishie
Kousei Ishigami
Yasuhiro Ushijima
Yukihisa Takayama
Daisuke Okamoto
Nobuhiro Fujita
Takao Ohtsuka
Tomoharu Yoshizumi
Shinichi Aishima
Yoshinao Oda
Hiroshi Honda
Publikationsdatum: 17.10.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 6/2017
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4621-y

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Prognostic significance of contrast-enhanced CT attenuation value in extrahepatic cholangiocarcinoma