Background
Materials and methods
Search strategy
Criteria for inclusion and exclusion
Data extraction and quality assessment
Statistical analysis
Results
Study characteristics
Study | Country | Cancer | Case number | Median age (year, range) | M/F | Stage | Gal-1 (±) NO. | Cut-off | Multivariate analysis | HR and 95% CI |
---|---|---|---|---|---|---|---|---|---|---|
Wu [5] | Japan | CCA | 78 | NA | 50/28 | TNM I–IV | (45/33) | IRS ≥ 3 | No | SC |
Chen [6] | China | gastric | 214 | Mean 64.5 | 129/85 | TNM I–IV | (138/76) | IRS ≥ 2 | No | SC |
Noda [9] | Japan | GSCC | 80 | Mean 63.8 | 39/41 | TNM I–IV | (22/58) | IHC > 50% | No | SC |
Chong [8] | China | Gastric | 111 | NA | NA | TNM I–IV | (61/50) | IHC > 20% | No | SC |
Zhang [10] | China | HCC | 209 | NA | 179/30 | TNM I–IV | (128/81) | IHC > 20% | No | SC |
Huang [13] | Tainan | RCC | 45 | NA | 31/14 | TNM I–IV | (25/20) | H-score > median | No | SC |
Le [14] | USA | HNSCC | 101 | Median 58 | 84/17 | TNM I–IV | (56/44) | IRS ≥ 3 | No | SC |
Schulz [15] | Germany | Ovarian | 150 | Median 62 (31–88) | 0/150 | FIGO I–IV | (102/48) | IRS > 1 | No | SC |
Chen [7] | China | Gastric | 108 | NA | 61/47 | TNM I–IV | (68/40) | IRS ≥ 2 | Yes | Report |
You [11] | China | HCC | 162 | NA | 127/35 | TNM I–IV | (105/57) | IRS ≥ 2 | Yes | Report |
Wu [12] | China | HCC | 386 | NA | 341/45 | TNM I–IV | (189/197) | NA | Yes | Report |
Kamper [19] | Denmark | cHL | 143 | 35 | 78/80 | Ann Arbor I–IV | (35/108) | NA | No | Report |
Ye [20] | China | LSCC | 187 | Mean 52.4 | 179/8 | TNM I–IV | (102/85) | NA | No | SC |
Szoke [17] | Hungary | NSCLC | 94 | Mean 58.8 | 84/10 | TNM I–III | (40/54) | NA | No | SC |
Carlini [18] | Argentina | NSCLC | 103 | Median 64 (45–85) | 69/34 | TNM I–III | (53/47) | IRS > 1 | No | SC |
Van Woensel [21] | Belgium | GBM | 349 | NA | NA | NA | (174/175) | Median gene expression | No | Report |
Chou [22] | China | GBM | 45 | NA | 27/18 | NA | (34/11) | IHC > 35% | No | Report |
Chen [16] | China | EOC | 109 | NA | 0/109 | FIGO | (91/18) | IRS ≥ 3 | Yes | Report |
Quality assessment
Meta-analysis results
Outcome subgroup | No. of studies | No. of patients | HR (95% CI) | P value | Model | Heterogeneity | |
---|---|---|---|---|---|---|---|
I2 (%) | P | ||||||
All | 18 | 2674 | 1.79 (1.54–2.08) | < 0.001 | Random | 43.6 | 0.025 |
Ethnicity | |||||||
Asian | 12 | 1734 | 1.96 (1.60–2.42) | < 0.001 | Random | 50.5 | 0.023 |
Caucasian | 6 | 940 | 1.42 (1.21–1.66) | < 0.001 | Fixed | 0.00 | 0.716 |
Tumor type | |||||||
Digestive system | 7 | 1268 | 1.94 (1.64–2.30) | < 0.001 | Fixed | 20.1 | 0.276 |
NOT digestive system | 11 | 1406 | 1.61 (1.33–1.94) | < 0.001 | Random | 42.5 | 0.066 |
Analysis type | |||||||
Univariate | 18 | 2674 | 1.79 (1.54–2.09) | < 0.001 | Random | 50.0 | 0.008 |
Multivariate | 4 | 765 | 1.93 (1.60–2.32) | < 0.001 | Fixed | 0.00 | 0.572 |
HR obtained method | |||||||
Reported in text | 7 | 1302 | 1.77 (1.42–2.20) | < 0.001 | Random | 49.2 | 0.066 |
Data extrapolated | 11 | 1372 | 1.77 (1.42–2.20) | < 0.001 | Random | 47.6 | 0.039 |