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Current Cardiology Reports
Erschienen in: Current Cardiology Reports 8/2015

01.08.2015 | Nuclear Cardiology (V Dilsizian, Section Editor)

Prognostic Significance of Imaging Myocardial Sympathetic Innervation

verfasst von: Saurabh Malhotra, Stanley F. Fernandez, James A. Fallavollita, John M. Canty Jr.

Erschienen in: Current Cardiology Reports | Ausgabe 8/2015

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Abstract

There has been a longstanding interest in understanding whether the presence of inhomogeneity in myocardial sympathetic innervation can predict patients at risk of sudden cardiac arrest from lethal ventricular arrhythmias. The advent of radiolabeled norepinephrine analogs has allowed this to be imaged in patients with ischemic and non-ischemic cardiomyopathy using single, photon emission computed tomography (SPECT) and positron emission tomography (PET). Several observational studies have demonstrated that globally elevated myocardial sympathetic tone (as reflected by reduced myocardial norepinephrine analog uptake) can predict composite cardiac end-points including total cardiovascular mortality. More recent studies have indicated that quantifying the extent of regional denervation can predict the risk of lethal ventricular arrhythmias and sudden cardiac death. This review will summarize our current understanding of the prognostic significance of altered myocardial sympathetic innervation.
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Metadaten
Titel
Prognostic Significance of Imaging Myocardial Sympathetic Innervation
verfasst von
Saurabh Malhotra
Stanley F. Fernandez
James A. Fallavollita
John M. Canty Jr.
Publikationsdatum
01.08.2015
Verlag
Springer US
Erschienen in
Current Cardiology Reports / Ausgabe 8/2015
Print ISSN: 1523-3782
Elektronische ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-015-0613-9

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