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Erschienen in: Heart Failure Reviews 6/2010

01.11.2010

Proinflammatory cytokines in heart failure: double-edged swords

verfasst von: Mona Hedayat, Mohammad Jafar Mahmoudi, Noel R. Rose, Nima Rezaei

Erschienen in: Heart Failure Reviews | Ausgabe 6/2010

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Abstract

Increased circulating and intracardiac levels of proinflammatory cytokines have been associated with chronic heart failure. Following an initial insult, the increased production of proinflammatory cytokines, including TNF-α, IL-6, IL-1, and IL-18, jeopardizes the surrounding tissue through propagation of the inflammatory response and direct effects on the cardiac myocyte structure and function. Cardiac myocyte hypertrophy, contractile dysfunction, cardiac myocyte apoptosis, and extracellular matrix remodeling contribute enormously to the development and progression of chronic heart failure. Despite the identification of efficacious pharmacological regimens and introduction of mechanical interventions, chronic heart failure remains among the leading causes of mortality worldwide. To introduce novel therapeutic strategies that modulate the inflammatory response in the context of the failing heart, it is of prime importance to determine the contributions of TNF-α, IL-6, IL-1, and IL-18 in mediating cardiac adaptive and maladaptive responses, as well as delineating their downstream intracellular signaling pathways and their potential therapeutic implications.
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Metadaten
Titel
Proinflammatory cytokines in heart failure: double-edged swords
verfasst von
Mona Hedayat
Mohammad Jafar Mahmoudi
Noel R. Rose
Nima Rezaei
Publikationsdatum
01.11.2010
Verlag
Springer US
Erschienen in
Heart Failure Reviews / Ausgabe 6/2010
Print ISSN: 1382-4147
Elektronische ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-010-9168-4

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