Erschienen in:
01.08.2014
Protective Effect of Melatonin on Infrarenal Aortic Occlusion: This Effect Is Related to Anti-inflammatory Effect and Antioxidant Effect
verfasst von:
Ahmet Ahsen, Yucel Gonul, Abdurrahman Genc, Memnune Sena Ulu, Murat Yagmurca, Cevdet Ugur Kocogullari, Sefa Celik, Seref Yuksel
Erschienen in:
Inflammation
|
Ausgabe 4/2014
Einloggen, um Zugang zu erhalten
Excerpt
Aortic cross-clamping is frequently exerted during surgery of the abdominal aorta (AA). Ischemia–reperfusion (IR) damage, which is observed in the surgery of AA, is a complex situation and is considered not only in lower extremities but also in remote tissues and organs like the lungs, kidneys, heart, and liver [
1‐
6]. IR damage leads to important morbidity and mortality because of its systemic complications [
7,
8]. Acute renal dysfunction, which is one of the most important complications following elective surgery of AA, is still a frequently seen condition (15–22 %), but acute kidney injury (AKI) is relatively rare (1.8–4 %) [
9,
10]. Infrarenal clamping of the aorta has been shown to decrease renal blood flow especially in patients who postoperatively developed renal failure [
11‐
13]. This clamping procedure can cause vasoconstriction in renal arteries by forming turbulent flow in the aorta at the level of renal arteries [
13]. …
