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Arthritis Research & Therapy
Erschienen in: Arthritis Research & Therapy 5/2007

01.10.2007 | Review

Proteinases in the joint: clinical relevance of proteinases in joint destruction

verfasst von: Yvonne Rengel, Caroline Ospelt, Steffen Gay

Erschienen in: Arthritis Research & Therapy | Ausgabe 5/2007

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Abstract

Proteinases are involved in essential steps in cartilage and bone homeostasis. Consequently, efforts have been made to establish their potential role in the pathology of rheumatic conditions such as rheumatoid arthritis, osteoarthritis and spondyloarthritis. Matrix metalloproteinases (MMPs) are sensitive markers of disease severity and response to treatment, and therefore they have potential in the assessment of rheumatic diseases. Despite disappointing early results with synthetic inhibitors of MMPs, there is still much scope for developing effective and safe MMPs inhibitors, and consequently to deliver new options to inhibit joint destruction.
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Metadaten
Titel
Proteinases in the joint: clinical relevance of proteinases in joint destruction
verfasst von
Yvonne Rengel
Caroline Ospelt
Steffen Gay
Publikationsdatum
01.10.2007
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 5/2007
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2304

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Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

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Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

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