Introduction
BENCI (90 min) | KILIFI TOOLKIT (120 MINUTES) | ||||
---|---|---|---|---|---|
Domain | Sub-test | Outcome Measures | Domain | Sub-test | Outcome Measures |
Processing Speed | Simple Reaction Time Test (a plus sign of the screen prompts the child to press a key on the keyboard fast) | Mean RT & Median RT | - | - | |
Visuo-motor Coordination | Visuo-motor test (involves connection of elements/number in a given sequence) | TT & Total Errors | |||
Sustained Attention | Continuous Performance Test (respondent presses any key every time the required stimulus appears) | Hits/CA, EO, EC, Mean RT & Median RT | Visual Sustained and Selective Attention Auditory Sustained and Selective Attention | People Search (A stimulus sheet comprising complete and incomplete stick figures is presented. The subject is required to cross out only complete figures, as quickly as possible) Digit span as we could not find the tape. The child is instructed to repeat a series of numbers (with increasing numbers of digits) forward. Each correct response is worth one point; with a maximum of 14 points for each sub-score series | TT, RT, Errors of Omission (EO) and Errors of Commission (EC) TT and Highest Score |
Memory | Verbal memory test (child listens to some words then repeats the ones remembered) Verbal memory delayed recall test (the series of words said are repeated after 20 min) Verbal Memory Essay of Recognition test (words are read out loud and respondents identifies those that were in the previous list) Visual memory (series of images are presented after which respondents verbalizes those remembered) Visual Memory delayed Essay (the images remembered are said out loud after 20 min) Visual Memory Essay of Recognition (respondent identifies if images presented were in previous list) | Hits/CA, P & I Hits/CA, P & I Hits/CA & Errors Hits/CA, EC & EO Hits/CA, EC & EO Hits/CA, EC & EO | Memory | Working Memory: Verbal List Learning – VLL (Two lists of 15 items are read out to the child as a shopping list. The first is presented five times and the second only once) Subtests within include: - Verbal Memory Test Free Recall Trial Test Short Delay Free Recall Trial Short Delay Cued Recall Trial Long Delay Free Recall Trial Long Delay Cued Recall Trial Long Delay Recognition Trial | Intrusions (I), Perseverations (P), CA and TT |
Language | Verbal Comprehension Images Test (respondent matches images to given conditions) Verbal Comprehension Figures (respondent matches geographic shapes to given conditions) Phonetic Fluency (a letter is presented and respondents verbalizes all words that start with the letter given.) | Hits/CA & Errors Hits/CA & Errors Hits/CA, I & P | - | - | |
Executive Functioning | Working Memory (a list of color and numbers are said and respondent repeats the numbers then the colors) Abstract Reasoning (respondent completes a logical series by selecting the right element) Semantic Fluency (a category is given and respondents says the elements known in that category) Inhibition: Go/NO-GO (respondents identifies distinguishing factor between two elements and later identify the distinguishing element) Flexibility: Spatial Stroop (respondent matches arrow directions to arrow labels) (Two components of spatial stroop—attention shifting task measures flexibility while proper spatial stroop task measures inhibition) Flexibility: Alternate Visuo-motor (is flexibility measure that involves two distinct series in which the respondent should connect alternatively) Planning: Attraction Park (respondent chooses a number of attractions according to money in hand with each attraction chosen expiring after a given period) | Hits/CA Hits/CA Hits/CA, I & P EC, Hits/CA & Mean RT Median RT, EC, EO TT & Total Errors Planning Time, TT, Rule 1, Rule 2, fairground amusements & different fairground amusements/CA | Executive Functioning | Self-Ordered Pointing Test—SOPT (Selection of pictures displayed in varying positions on separate sheets in sets of 6, 8, 10, and 12. As each page is turned the subject is required to identify all members of the set, but to point to each item of the set only once. Touching a picture more than once is considered an error) Raven progressive matrices: Reasoning: Colored Progressive Matrices – CPM (Three sets with 12 matrices made of abstract patterns. The subject is asked to complete the matrix by placing one of a choice of four patterns in the empty space) Attention and attention shift: Contingency Naming Test – CNT (The child is taught a series of rules to name nine drawings displayed in a single series. Each drawing consists of a large outer colored shape and a smaller inner colored shape. Each drawing is named according to the shape or color of one of its two shapes. The rules taught for selecting the name of the item become more complex over four trials) Planning: Tower Test/ Tower of London (Three colored wooden balls are moved between three pegs to match a goal position. Time and number of moves required are recorded) | Time Taken(TT), Reaction Time(RT) and Correct Answers (CA) |
Methodology
Participants and settings
Measures
The BENCI Adaptation process
Procedure
Analyses
Results
Variables | HIV Negative N (%) | HIV Positive N (%) | |
---|---|---|---|
Gender | Male | 163 (49.40) | 148 (54.00) |
Female | 166 (50.30) | 125 (45.60) | |
Missing | 1 (0.30) | 1 (0.40) | |
Age in months (Mean ± SD) | 117.2 ± 16.24 | 119.40 ± 14.63 | |
Age in Years (Mean ± SD) | 9.41 ± 1.37 | 9.56 ± 1.24 | |
Nutrition | Weight in kg (Mean ± SD) | 34.98 ± 7.12 | 32.27 ± 5.85 |
Height in cm (Mean ± SD) | 136.34 ± 8.00 | 133.02 ± 8.11 |
Scale attenuation effects
Internal consistency of the BENCI
BENCI Subtests | No. of Items | Skewness | Overall Cronbach's Alpha | HIV Negative Cronbach's Alpha | HIV Positive Cronbach's Alpha |
---|---|---|---|---|---|
Verbal comprehension images Time | 8 | 3.113 | .689 | .519 | .682 |
Verbal comprehension images Hits | 8 | -1.302 | 0.592 | 0.386 | 0.602 |
Verbal comprehension figures Time | 8 | 1.926 | 0.613 | 0.56 | 0.609 |
Verbal comprehension figures Hits | 8 | -.737 | 0.496 | 0.349 | 0.571 |
Abstract reasoning Hits | 25 | .019 | 0.832 | 0.813 | 0.781 |
Abstract reasoning Time | 25 | .851 | 0.890 | 0.904 | 0.875 |
Go No Go Total Hits | 101 | -.745 | 0.870 | 0.824 | 0.895 |
Go No Go Total Time | 101 | 1.136 | 0.879 | 0.872 | 0.864 |
Planning Total time | 12 | .895 | 0.753 | 0.760 | 0.744 |
Spatial Stroop Hits | 90 | -.933 | 0.973 | 0.966 | 0.975 |
Spatial Stroop Time | 90 | -1.701 | 0.950 | 0.924 | 0.959 |
Processing speed Reaction Time | 50 | 1.598 | 0.832 | 0.832 | 0.822 |
Test (N = 38) | First Visit Mean (sd) | Second Visit Mean (sd) | ICC | CI 95% | Pearson correlation |
---|---|---|---|---|---|
Visuomotor Coordination (TT) | 73,772.32 (34,587.11) | 54,539.74 (27,326.12) | .66** | .35—.82 | .51** |
Alternate Visuomotor Coordination (TT) | 75,473.65 (32,581.90) | 50,385.71 (23,478.43) | .74** | .49—.87 | .62** |
Sustained Attention CPT (CA) | 49.06 (12.06) | 51.70 (6.26) | .13 | -.74—.57 | .08 |
Sustained Attention CPT (RT) | 626.96 (191.41) | 618.57 (196.13) | .81** | .62—.90 | .68** |
Immediate Verbal Memory (CA) | 5.19 (2.60) | 6.26 (3.38) | .58* | .12—.77 | .39* |
Delayed Verbal Memory (CA) | 5.30 (3.01) | 5.58 (3.00) | .71** | .44—.85 | .55** |
Verbal Recognition Memory (CA) | 18.89 (3.49) | 20.00 (3.08) | .41 | -.15—.70 | .26 |
Immediate Visual Memory (CA) | 5.76 (2.60) | 6.30 (3.29) | .75** | .51—.87 | .61** |
Delayed Visual Memory (CA) | 5.35 (3.22) | 6.47 (3.29) | .55* | .13—.77 | .38* |
Visual Recognition Memory (CA) | 44.30 (6.08) | 45.47 (4.11) | .52* | .07—.75 | .38* |
Comprehension of Images (CA) | 7.53 (0.97) | 7.78 (0.42) | .49* | -.01—.74 | .45* |
Working Memory (CA) | 11.58 (5.69) | 13.76 (4.92) | .71** | .43—.85 | .55** |
Reasoning (CA) | 13.89 (4.11) | 15.74 (4.39) | -.34 | -1.63—.32 | -.15 |
Semantic Fluency (CA) | 8.00 (3.01) | 6.84 (3.58) | .64* | .30—.81 | .48* |
Phonetic Fluency (CA) | 4.89 (2.48) | 5.68 (2.83) | .48* | -.00—.73 | .32 |
Go/No-Go (CA) | 0.87 (0.14) | 0.84 (0.16) | .43* | -11—.71 | .27 |
Go/No-Go (RT) | 0.64 (0.08) | 0.66 (0.11) | .14 | -.71—.56 | .08 |
Selective Attention (RT) | 575.21 (148.28) | 573.16 (153.80) | .66** | .32—.83 | .49* |
Planning FO (RT) | 5047.03 (5865.45) | 2600.13 (3168.40) | .43* | -.11—.71 | .32* |
Tests retest reliability of the BENCI
Convergent validity
BENCI Tests | Kilifi Toolkit Tests | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
People Search test | Digit Span test | Contingency Naming test | Self-Ordered Pointing Test | Verbal List Learning (VLL) test – Total CA | Nonverbal Selective Reminding Memory Test (NVSRT) | Tower Test | Ravens Progressive Matrices test | VLL Immediate Memory Span | VLL Level of Learning | ||
Domains | Visual Sustained and Selective Attention | Auditory Sustained and Selective Attention | EF: Flexibility—Attention and attention shift | EF: Working Memory | Memory | Non-Verbal Memory | EF: Inhibition—Planning | EF: Reasoning | Memory | Memory | |
Sustained Attention CPT (CA) | Sustained Attention | -0.103 | 0.053 | -0.157 | 0.093 | .303b | 0.089 | 0.056 | .288 b | 0.056 | .266 b |
Sustained Attention CPT (RT) | Sustained Attention | 0.123 | -0.024 | 0.130 | -0.043 | -0.110 | 0.123 | 0.066 | -0.151 | 0.066 | -0.062 |
Working Memory (CA) | EF: Working Memory | .194 a | -0.124 | -0.047 | 0.004 | .276 b | 0.085 | -0.143 | 0.049 | -0.143 | .297 b |
Verbal memory (CA) | Memory | -0.006 | 0.005 | -0.030 | 0.014 | .414 b | -0.181 | -0.165 | .346 b | -0.165 | .372 b |
Verbal Memory Delayed (CA) | Memory | -0.038 | 0.043 | -0.089 | 0.116 | 0.193 | -0.102 | -0.171 | 0.162 | -0.171 | .212 a |
Verbal Memory Recognition (CA) | Memory | -0.010 | -0.025 | -0.001 | 0.068 | -0.076 | 0.012 | -.186a | -0.073 | -.186 a | -0.085 |
Planning Total Time | EF: Inhibition—Planning | -0.083 | -0.176 | .279b | -0.011 | -0.030 | -.405 b | -.209a | -0.010 | -.209a | 0.004 |
Planning Time FO | EF: Inhibition—Planning | -0.169 | -0.128 | .219 a | -0.070 | -0.060 | -.310 b | -0.113 | 0.047 | -0.113 | -0.028 |
Reasoning (CA) | EF: Reasoning | -.367 b | 0.119 | 0.042 | 0.000 | .424 b | -.279 b | -0.087 | .206a | -0.087 | .380 b |
Visual Memory Immediate (CA) | Memory | 0.041 | 0.012 | 0.010 | -0.081 | .322 b | -0.112 | 0.060 | 0.119 | 0.060 | .234 a |
Visual Memory Delayed (CA) | Memory | 0.038 | -0.033 | -0.007 | 0.064 | .252 a | -0.088 | -0.179 | .261 a | -0.179 | 0.220 |
Visual Memory Recognition (CA) | Memory | -0.109 | 0.215 | -0.057 | 0.092 | 0.129 | -0.022 | 0.008 | 0.078 | 0.008 | 0.047 |
Spatial Stroop Flexibility | EF: Flexibility | -0.142 | 0.086 | 0.027 | 0.084 | .414 b | -.202a | -0.037 | .327 b | -0.037 | .361 b |
The BENCI functionality in age and HIV groups
N | Mean | Std. Deviation | Std. Error Mean | Mean Difference | Significance (2-tailed) | ||
---|---|---|---|---|---|---|---|
Verbal Comprehension Figures Hits | HIV negative | 317 | 7.030 | .990 | .056 | .498 | .000 |
HIV positive | 258 | 6.530 | 1.171 | .073 | |||
Verbal Comprehension Images Hits | HIV negative | 318 | 7.540 | .743 | .042 | .760 | .000 |
HIV positive | 259 | 6.780 | 1.220 | .076 | |||
Continuous performance Hits | HIV negative | 322 | 47.329 | 12.756 | .712 | 1.928 | .097 |
HIV positive | 264 | 45.401 | 14.891 | .916 | |||
Continuous performance RT Median | HIV negative | 318 | 585.997 | 149.796 | 8.400 | 20.093 | .061 |
HIV positive | 260 | 565.904 | 107.263 | 6.652 | |||
Go No Go Hits | HIV negative | 315 | 42.333 | 8.007 | .451 | .287 | .709 |
HIV positive | 258 | 42.047 | 9.968 | .621 | |||
Go No Go Mean RT | HIV negative | 315 | .825 | .007 | .000 | -.002 | .023 |
HIV positive | 252 | .827 | .009 | .001 | |||
Processing Speed Median Reaction Time | HIV negative | 313 | 584.931 | 146.541 | 8.283 | 20.6036 | .048 |
HIV positive | 267 | 564.328 | 102.179 | 6.253 | |||
Phonetic Fluency Hits | HIV negative | 319 | 5.100 | 2.729 | .153 | 1.658 | .000 |
HIV positive | 271 | 3.440 | 2.546 | .155 | |||
Semantic Fluency Hits | HIV negative | 321 | 7.310 | 3.295 | .184 | 1.909 | .000 |
HIV positive | 271 | 5.410 | 3.440 | .209 | |||
Working Memory Hits | HIV negative | 319 | 10.510 | 6.060 | .339 | 1.955 | .000 |
HIV positive | 270 | 8.560 | 6.314 | .384 | |||
Verbal Memory Hits | HIV negative | 264 | 6.240 | 2.249 | .138 | .747 | .000 |
HIV positive | 206 | 5.500 | 2.040 | .142 | |||
Verbal Memory Hits Delayed | HIV negative | 317 | 4.670 | 3.192 | .179 | 1.125 | .000 |
HIV positive | 270 | 3.540 | 2.706 | .165 | |||
Verbal Memory Hits Recognition | HIV negative | 317 | 18.310 | 3.533 | .198 | .517 | .089 |
HIV positive | 270 | 17.790 | 3.810 | .232 | |||
Planning Total Time | HIV negative | 303 | 18,178.770 | 12,791.017 | 734.825 | 148.873 | .891 |
HIV positive | 259 | 18,029.900 | 12,776.036 | 793.864 | |||
Planning Time of First Option | HIV negative | 304 | 3404.050 | 3027.831 | 173.658 | -567.889 | .036 |
HIV positive | 259 | 3971.940 | 3316.305 | 206.065 | |||
Abstract Reasoning Hits | HIV negative | 319 | 14.870 | 4.835 | .271 | 4.261 | .000 |
HIV positive | 269 | 10.610 | 4.775 | .291 | |||
Visual Motor Total time | HIV negative | 320 | 70,080.740 | 28,797.814 | 1609.847 | -18,559.339 | .000 |
HIV positive | 254 | 88,640.080 | 35,451.218 | 2224.407 | |||
Alternative Visual-Motor Total Time | HIV negative | 315 | 74,940.830 | 36,611.539 | 2062.827 | -22,239.897 | .000 |
HIV positive | 255 | 97,180.730 | 45,435.071 | 2845.254 | |||
Visual Memory Immediate Hits | HIV negative | 278 | 6.140 | 2.295 | .138 | 1.277 | .000 |
HIV positive | 207 | 4.860 | 2.030 | .141 | |||
Visual Memory Delayed Hits | HIV negative | 273 | 6.150 | 2.459 | .149 | 1.289 | .000 |
HIV positive | 201 | 4.860 | 1.990 | .140 | |||
Visual Memory Recognition Hits | HIV negative | 314 | 44.580 | 5.122 | .289 | 1.527 | .003 |
HIV positive | 264 | 43.050 | 6.975 | .429 | |||
Spatial Stroop Hits | HIV negative | 328 | 66.500 | 21.956 | 1.212 | 7.270 | .000 |
HIV positive | 270 | 59.230 | 23.769 | 1.447 | |||
Spatial Stroop Omission Errors | HIV negative | 328 | 9.050 | 10.469 | .578 | -5.962 | .000 |
HIV positive | 270 | 15.010 | 16.667 | 1.014 | |||
Spatial Stroop Commission Errors | HIV negative | 328 | 11.710 | 15.242 | .842 | -2.719 | .032 |
HIV positive | 270 | 14.430 | 15.571 | .948 | |||
Spatial Stroop Mean Time | HIV negative | 328 | 979.504 | 223.457 | 12.338 | -68.133 | .001 |
HIV positive | 270 | 1047.638 | 249.922 | 15.210 |
HIV Positive | HIV Negative | |||||
---|---|---|---|---|---|---|
Pearson Correlation | Sig. (2-tailed) | N | Pearson Correlation | Sig. (2-tailed) | N | |
Age in years | 252 | 292 | ||||
Verbal comprehension Images Hits | .188b | .004 | 239 | .038 | .520 | 283 |
Continuous Performance Hits | -.050 | .435 | 244 | -.004 | .945 | 288 |
Continuous Performance RT Median | -.054 | .409 | 240 | -.168b | .004 | 285 |
Go No Go Total Hits | .074 | .253 | 239 | -.023 | .698 | 281 |
Go No Go Mean RT | -.113 | .085 | 233 | .048 | .422 | 281 |
Processing Speed Median Reaction Time | -.123 | .053 | 247 | -.156b | .009 | 279 |
Phonetic Fluency Hits | -.063 | .321 | 250 | .034 | .571 | 284 |
Semantic Fluency Hits | .025 | .689 | 250 | .006 | .921 | 286 |
Working Memory Hits | -.046 | .468 | 249 | -.100 | .094 | 284 |
Verbal Memory Hits | .156a | .032 | 190 | .255b | .000 | 234 |
Verbal Memory Hits Delayed | .048 | .450 | 249 | -.006 | .921 | 282 |
Verbal Memory Hits recognition | .151a | .017 | 249 | .034 | .564 | 282 |
Planning Total Time | .128a | .049 | 238 | -.015 | .803 | 267 |
Planning Time of First Option | .237b | .000 | 240 | .006 | .922 | 269 |
Abstract Reasoning Hits | .156a | .014 | 248 | .210b | .000 | 284 |
Visual Motor Total Time | -.126 | .055 | 233 | -.083 | .161 | 285 |
Alternative Visual Motor Total Time | .105 | .108 | 237 | -.006 | .914 | 281 |
Visual Memory Immediate Hits | .160a | .027 | 191 | .082 | .196 | 248 |
Visual Memory Delayed Hits | .096 | .195 | 185 | .230b | .000 | 243 |
Visual Memory Recognition Hits | .150a | .019 | 245 | .037 | .541 | 279 |
Spatial Stroop Hits | .106 | .095 | 249 | .034 | .561 | 292 |
Spatial Stroop Omission Errors | -.152a | .017 | 249 | -.082 | .163 | 292 |
Spatial Stroop Commission Errors | -.013 | .838 | 249 | .003 | .964 | 292 |
Spatial Stroop Mean Time | -.017 | .788 | 249 | -.072 | .218 | 292 |