Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
AIDS and Behavior
Erschienen in: AIDS and Behavior 12/2020

11.05.2020 | Original Paper

Psychosocial Factors, Condomless Sex, and Detectable Viral Load in HIV-Positive Women in Serodiscordant Couples in Nairobi, Kenya

verfasst von: Michela Blain, Barbra A. Richardson, John Kinuthia, Danielle N. Poole, Walter Jaoko, Kate S. Wilson, Anne Kaggiah, Jane M. Simoni, Carey Farquhar, R. Scott McClelland

Erschienen in: AIDS and Behavior | Ausgabe 12/2020

Einloggen, um Zugang zu erhalten

Abstract

This prospective study of HIV-positive Kenyan women in serodiscordant couples examined relationships between psychosocial factors, viral suppression, and condomless sex. Participants were screened for alcohol use disorders and intimate partner violence (IPV) annually and depressive symptoms every 6 months. Prostate specific antigen (PSA) detection was used as a marker for condomless sex. A total of 151 participants contributed 349 person-years of follow-up. Hazardous/harmful alcohol use was associated with increased risk of detecting PSA in vaginal secretions (aRR 1.99, 95%CI 1.08–3.66, χ2 = 4.85 (1)), while IPV and depression were not. Events representing HIV transmission potential, where there was biological evidence of condomless sex at a visit with a detectable plasma viral load, were observed at 2% of visits. The high prevalence of IPV and association between alcohol use and sexual risk suggest the need for monitoring and support for these conditions as part of comprehensive HIV care for women.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
2.
3.
Lurie MN, Williams BG, Zuma K, Mkaya-Mwamburi D, Garnett GP, Sweat MD, et al. Who infects whom? HIV-1 concordance and discordance among migrant and non-migrant couples in South Africa. AIDS [Internet]. 2003;17(15):2245–52.PubMed
4.
Ngilangwa DP, Ochako R, Mboya BA, Noronha RH, Mgomella GS. Prevalence and predictors of HIV sero-discordance among cohabiting couples tested in northern Tanzania. Pan Afr Med J. 2015;22:275.PubMedPubMedCentral
5.
Chemaitelly H, Awad SF, Abu-Raddad LJ. The risk of HIV transmission within HIV-1 sero-discordant couples appears to vary across sub-saharan africa. Epidemics. 2014;6:1–9.PubMed
6.
WHO. GUIDANCE ON COUPLES HIV TESTING AND COUNSELLING INCLUDING ANTIRETROVIRAL THERAPY FOR TREATMENT AND PREVENTION IN SERODISCORDANT COUPLES Recommendations for a public health approach [Internet]. Vol. 71, GUIDANCE ON COUPLES HIV TESTING AND COUNSELLING INCLUDING ANTIRETROVIRAL THERAPY FOR TREATMENT AND PREVENTION IN SERODISCORDANT COUPLES Recommendations for a public health approach. 2012. Available from: https://​www.​ncbi.​nlm.​nih.​gov/​pubmed/​22543954
7.
WHO. Consolidated Guidlines on the use of Anteretroviral Drugs for Treating and Preventing HIV Infection: Recommendations for a Public Health Approach. WHO 2013 Consolidated Guidelines. 2013.
8.
Muessig KE, Cohen MS. Advances in HIV prevention for serodiscordant couples. Curr HIV/AIDS Rep. 2014;11(4):434–46.PubMedPubMedCentral
9.
Chersich MF, Bosire W, King’ola N, Temmerman M, Luchters S. Effects of hazardous and harmful alcohol use on HIV incidence and sexual behaviour: a cohort study of Kenyan female sex workers. Glob Health. 2014;10:22.
10.
Weiser SD, Leiter K, Heisler M, McFarland W, Percy-De Korte F, DeMonner SM, et al. A population-based study on alcohol and high-risk sexual behaviors in Botswana. PLoS Med. 2006;3(10):1940–8.
11.
Jewkes RK, Dunkle K, Nduna M, Shai N. Intimate partner violence, relationship power inequity, and incidence of HIV infection in young women in South Africa: a cohort study. Lancet. 2015;376(9734):41–8.
12.
Sullivan KA, Messer LC, Quinlivan EB. Substance abuse, violence, and HIV/AIDS (SAVA) syndemic effects on viral suppression among HIV positive women of color. AIDS Patient Care STDS. 2015;29(Suppl 1):s42–s4848.PubMedPubMedCentral
13.
Nakimuli-Mpungu E, Mojtabai R, Alexandre PK, Musisi S, Katabira E, Nachega JB, et al. Lifetime depressive disorders and adherence to anti-retroviral therapy in HIV-infected Ugandan adults: a case-control study. J Affect Disord. 2013;145(2):221–6.PubMed
14.
Lundberg P, Rukundo G, Ashaba S, Thorson A, Allebeck P, Ostergren PO, et al. Poor mental health and sexual risk behaviours in Uganda: a cross-sectional population-based study. BMC Public Health. 2011;11:125.PubMedPubMedCentral
15.
Soboka M, Tesfaye M, Feyissa GT, Hanlon C. Alcohol use disorders and associated factors among people living with HIV who are attending services in south west Ethiopia. BMC Res Notes. 2014;7(1):828.PubMedPubMedCentral
16.
Brandt R. The mental health of people living with HIV/AIDS in Africa: a systematic review. Afr J AIDS Res. 2009;8(2):123–33.PubMed
17.
Vagenas P, Azar MM, Copenhaver MM, Springer SA, Molina PE, Altice FL. The impact of alcohol use and related disorders on the HIV continuum of care: a systematic review: alcohol and the HIV continuum of care. Curr. HIV/AIDS Rep. 2015;12(4):421–36.PubMedPubMedCentral
18.
Devries KM, Mak JYT, García-Moreno C, Petzold M, Child JC, Falder G, et al. The global prevalence of intimate partner violence against women. Science (80- ) 2013;340(Ci):27–8
19.
Shamu S, Abrahams N, Zarowsky C, Shefer T, Temmerman M. Intimate partner violence during pregnancy in Zimbabwe: a cross-sectional study of prevalence, predictors and associations with HIV. Trop Med Int Health. 2013;18(6):696–711.PubMed
20.
Kouyoumdjian FG, Calzavara LM, Bondy SJ, O’ campo P, Serwadda D, Nalugoda F, et al. Intimate partner violence is associated with incident HIV infection in women in Uganda. Wolters Kluwer Health AIDS. 2013;27:1331–8.
21.
Wilson KS, Deya R, Yuhas K, Simoni J, Vander Stoep A, Shafi J, et al. A prospective cohort study of intimate partner violence and unprotected sex in HIV-positive female sex workers in Mombasa, Kenya. AIDS Behav. 2016;20(9):2054–64.PubMedPubMedCentral
22.
Mittal M, Senn TE, Carey MP. Intimate partner violence and condom use among women: Does the information-motivation-behavioral skills model explain sexual risk behavior? AIDS Behav. 2012;16(4):1011–9.PubMedPubMedCentral
23.
Illangasekare S, Tello M, Hutton H, Moore R, Anderson J, Baron J, et al. Clinical and mental health correlates and risk factors for intimate partner violence among HIV-positive women in an inner-city HIV clinic. Women’s Heal Issues. 2012;22(6):563–9.
24.
Trimble DD, Nava A, McFarlane J. Intimate partner violence and antiretroviral adherence among women receiving care in an urban southeastern Texas HIV clinic. J Assoc Nurses AIDS Care. 2013;24(4):331–40.PubMed
25.
Myer L, Smit J, Le RL, Parker S, Stein DJ, Seedat S. Common mental disorders among HIV-infected individuals in South Africa: prevalence, predictors, and validation of brief psychiatric rating scales. AIDS Patient Care STDS. 2008;22(2):147–58.PubMed
26.
Cohen MH, Fabri M, Cai X, Shi Q, Hoover DR, Binagwaho A, et al. Prevalence and Predictors of Posttraumatic Stress Disorder and Depression in HIV-Infected and At-Risk Rwandan Women. J Women’s Health. 2009;18(11):1783–91.
27.
28.
Taniguchi T, Shacham E, Önen NF, Grubb JR, Overton ET. Depression severity is associated with increased risk behaviors and decreased CD4 cell counts. AIDS Care. 2014;26(8):1004–122.PubMedPubMedCentral
29.
Nakimuli-Mpungu E, Bass JK, Alexandre P, Mills EJ, Musisi S, Ram M, et al. Depression, alcohol use and adherence to antiretroviral therapy in sub-Saharan Africa: A systematic review. AIDS Behav. 2012;16:2101–8.PubMed
30.
Starace F, Ammassari A, Trotta MP, Murri R, De Longis P, Izzo C, et al. Depression is a risk factor for suboptimal adherence to highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2002;31(Suppl 3):S136–S139139.PubMed
31.
Pence BW, Miller WC, Gaynes BN, Eron JJ. Psychiatric illness and virologic response in patients initiating highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2007;44(2):159–66.PubMed
32.
Do NT, Phiri K, Bussmann H, Gaolathe T, Marlink RG, Wester CW. Psychosocial factors affecting medication adherence among HIV-1 infected adults receiving combination antiretroviral therapy (cART) in Botswana. AIDS Res Hum Retroviruses. 2010;26(6):685–91.PubMedPubMedCentral
33.
Davis EC, Rotheram-Borus MJ, Weichle TW, Rezai R, Tomlinson M. Patterns of Alcohol Abuse, Depression, and Intimate Partner Violence Among Township Mothers in South Africa Over 5 Years. AIDS Behav. 2017;21(Suppl 2):172–82.
34.
Kiene SM, Lule H, Sileo KM, Silmi KP, Wanyenze RK. Depression, alcohol use, and intimate partner violence among outpatients in rural Uganda: vulnerabilities for HIV, STIs and high risk sexual behavior. BMC Infect Dis. 2017;17(1):88.PubMedPubMedCentral
35.
Pack AP, L’Engle K, Mwarogo P, Kingola N, Engle KL, Mwarogo P, et al. Intimate partner violence against female sex workers in Mombasa, Kenya. Cult Health Sex. 2014;16(3):217–30.
36.
Nduna M, Jewkes RK, Dunkle KL, Shai NPJ, Colman I. Associations between depressive symptoms, sexual behaviour and relationship characteristics: A prospective cohort study of young women and men in the Eastern Cape, South Africa. J Int AIDS Soc. 2010;13(1):44.PubMedPubMedCentral
37.
Devries KM, Child JC, Bacchus LJ, Mak J, Falder G, Graham K, et al. Intimate partner violence victimization and alcohol consumption in women: A systematic review and meta-analysis. Addiction. 2014;109:379–91.PubMed
38.
Gonzalez JMR, Connell NM, Businelle MS, Jennings WG, Chartier KG. Characteristics of adults involved in alcohol-related intimate partner violence: results from a nationally representative sample. BMC Public Health. 2014;14(1):466.PubMed
39.
Ellsberg M, Jansen HAFM, Heise L, Watts CH, García-Moreno C. Intimate partner violence and women’s physical and mental health in the WHO multi-country study on women’s health and domestic violence: an observational study. Lancet. 2008;371:1165–72.PubMed
40.
El-Bassel N, Gilbert L, Wu E, Go H, Hill J. HIV and intimate partner violence among methadone-maintained women in New York City. Soc Sci Med. 2005;61(1):171–83.PubMed
41.
White D, Wilson KS, Masese LN, Wanje G, Jaoko W, Mandaliya K, et al. Alcohol use and associations with biological markers and self-reported indicators of unprotected sex in human immunodeficiency virus-positive female sex workers in Mombasa, Kenya. Sex Transm Dis. 2016;43(10):642–7.PubMedPubMedCentral
42.
43.
MacAluso M, Lawson L, Akers R, Valappil T, Hammond K, Blackwell R, et al. Prostate-specific antigen in vaginal fluid as a biologic marker of condom failure. Contraception. 1999;59(3):195–201.PubMed
44.
Minnis AM, Steiner MJ, Gallo MF, Warner L, Hobbs MM, van der Straten A, et al. Biomarker validation of reports of recent sexual activity: results of a randomized controlled study in Zimbabwe. Am J Epidemiol. 2009;170(7):918–24.PubMedPubMedCentral
45.
Graham SM, Masese L, Gitau R, Jalalian-Lechak Z, Richardson BA, Peshu N, et al. Antiretroviral adherence and development of drug resistance are the strongest predictors of genital HIV-1 shedding among women initiating treatment. J Infect Dis. 2010;202(10):1538–42.PubMedPubMedCentral
46.
El-Khatib Z, Katzenstein D, Marrone G, Laher F, Mohapi L, Petzold M, et al. Adherence to drug-refill is a useful early warning indicator of virologic and immunologic failure among HIV patients on first-line art in South Africa. PLoS ONE. 2011;6(3):e17518.PubMedPubMedCentral
47.
48.
Dybek I, Bischof G, Grothues J, Reinhardt S, Meyer C, Hapke U, et al. The reliability and validity of the Alcohol Use Disorders Identification Test (AUDIT) in a German general practice population sample. J Stud Alcohol. 2006;67:473–81.PubMed
49.
Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M. Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption???II. Addiction. 1993;88(6):791–804.PubMed
50.
Reinert DF, Allen JP. The alcohol use disorders identification test: An update of research findings. Alcohol Clin Exp Res. 2007;Vol. 31:185–99.
51.
Schraiber LB, do Rosário DiasO Latorre M, França I, Segri NJ, LucasD’Oliveira AFP. Validity of the WHO VAW study instrument for estimating gender-based violence against women. Rev Saude Publica. 2010;44(4):658–66.
52.
Garcio-Moreno C, Jansen HAFM, Elsberg M. Prevalence of intimate partner violence: findings from the WHO multi-country study on women’s health and domestic violence. Lancet. 2006;368(9543):1260–9.
53.
Frazier T, Yount K. Intimate partner violence screening and the comparative effects of screening mode on disclosure of sensitive health behaviours and exposures in clinical settings. Public Health. 2017;143:52–9.PubMed
54.
Wilson KS, Wanje G, Yuhas K, Simoni JM, Masese L, Vander Stoep A, et al. A prospective study of intimate partner violence as a risk factor for detectable plasma viral load in HIV-positive women engaged in transactional sex in Mombasa, Kenya. AIDS Behav. 2016;20(9):2065–77.PubMedPubMedCentral
55.
Kroenke K, Spitzer RL, Williams JBW. The PHQ-9: Validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606–13.PubMedPubMedCentral
56.
Monahan PO, Shacham E, Reece M, Kroenke K, Ong’Or WO, Omollo O, et al. Validity/reliability of PHQ-9 and PHQ-2 depression scales among adults living with HIV/AIDS in Western Kenya. J Gen Intern Med. 2009;24(2):189–97.PubMed
57.
Gelaye B, Williams MA, Lemma S, Deyessa N, Bahretibeb Y, Shibre T, et al. Validity of the patient health questionnaire-9 for depression screening and diagnosis in East Africa. Psychiatry Res. 2013;210(2):653–61.PubMed
58.
Cholera R, Gaynes BN, Pence BW, Bassett J, Qangule N, Macphail C, et al. Validity of the patient health questionnaire-9 to screen for depression in a high-HIV burden primary healthcare clinic in Johannesburg, South Africa. J Affect Disord. 2014;167:160–6.PubMedPubMedCentral
59.
Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika. 1986;73(1):13–22.
60.
61.
Kiene SM, Subramanian SV. Event-level association between alcohol use and unprotected sex during last sex: evidence from population-based surveys in sub-Saharan Africa. BMC Public Health. 2013;13(1):583.PubMedPubMedCentral
62.
Glass TR, De Geest S, Weber R, Vernazza PL, Rickenbach M, Furrer H, et al. Correlates of self-reported nonadherence to antiretroviral therapy in HIV-infected patients: The Swiss HIV Cohort Study. J Acquir Immune Defic Syndr. 2006;41(3):385–92.PubMed
63.
Shuper PA, Joharchi N, Irving H, Rehm J. Alcohol as a correlate of unprotected sexual behavior among people living with HIV/AIDS: review and meta-analysis. AIDS Behav. 2009;13(6):1021–36.PubMed
64.
Scott-Sheldon LAJ, Walstrom P, Carey KB, Johnson BT, Carey MP. Alcohol Use and Sexual Risk Behaviors among Individuals Infected with HIV: A Systematic Review and Meta-Analysis 2012 to Early 2013. Curr HIV/AIDS Rep. 2013;10(4):314–23.PubMedPubMedCentral
65.
Fisher JC, Bang H, Kapiga SH. The association between HIV infection and alcohol use: a systematic review and meta-analysis of African studies. Sex Transm Dis. 2007;34(11):856–63.PubMed
66.
Kalichman SC, Simbayi LC, Kaufman M, Cain D, Jooste S. Alcohol use and sexual risks for HIV/AIDS in sub-saharan Africa: Systematic review of empirical findings. Prev Sci. 2007;8(2):141–51.PubMed
67.
Gallo MF, Behets FM, Steiner MJ, Hobbs MM, Hoke TH, Van Damme K, et al. Prostate-specific antigen to ascertain reliability of self-reported coital exposure to semen. Sex Transm Dis. 2006;33(8):476–9.PubMed
68.
Hochmeister MN, Budowle B, Rudin O, Gehrig C, Borer U, Thali M, et al. Evaluation of prostate-specific antigen (PSA) membrane test assays for the forensic identification of seminal fluid. J Forensic Sci. 1999;44(5):1057–60.PubMed
69.
Kerridge BT, Tran P, Hasin DS. Intoxication at Last Sexual Intercourse and Unprotected Sex among HIV-Positive and HIV-Negative Individuals in Uganda: An Event-Level Analysis. AIDS Behav. 2015;19(3):412–21.PubMedPubMedCentral
70.
Byrd KK, Hou JG, Hazen R, Kirkham H, Suzuki S, Clay PG, et al. Antiretroviral Adherence Level Necessary for HIV Viral Suppression using Real-World Data. JAIDS J Acquir Immune Defic Syndr. 2019;82(3):245–51.PubMed
71.
Gallo MF, Behets FM, Steiner MJ, Thomsen SC, Ombidi W, Luchters S, et al. Validity of self-reported “safe sex” among female sex workers in Mombasa, Kenya—PSA analysis. Int J STD AIDS. 2007;18(1):33–8.PubMed
72.
Crepaz N, Marks G. Are negative affective states associated with HIV sexual risk behaviors? A meta-analytic review. Health Psychol. 2001;20(4):291–9.PubMed
73.
Musisi S, Wagner GJ, Ghosh-Dastidar B, Nakasujja N, Dickens A, Okello E. Depression and sexual risk behaviour among clients about to start HIV antiretroviral therapy in Uganda. Int J STD AIDS. 2014;25(2):130–7.PubMed
74.
Ammassari A, Antinori A, Aloisi MS, Trotta MP, Murri R, Bartoli L, et al. Depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy among HIV-infected persons. Psychosomatics. 2004;45(5):394–402.PubMed
Metadaten
Titel
Psychosocial Factors, Condomless Sex, and Detectable Viral Load in HIV-Positive Women in Serodiscordant Couples in Nairobi, Kenya
verfasst von
Michela Blain
Barbra A. Richardson
John Kinuthia
Danielle N. Poole
Walter Jaoko
Kate S. Wilson
Anne Kaggiah
Jane M. Simoni
Carey Farquhar
R. Scott McClelland
Publikationsdatum
11.05.2020
Verlag
Springer US
Erschienen in
AIDS and Behavior / Ausgabe 12/2020
Print ISSN: 1090-7165
Elektronische ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-020-02907-0

Weitere Artikel der Ausgabe 12/2020

AIDS and Behavior 12/2020 Zur Ausgabe

Notes From The Field

Attendance to HIV Antiretroviral Collection Clinic Appointments During COVID-19 Lockdown. A Single Center Study in Kigali, Rwanda

Original Paper

Antiretroviral Adherence, Drug Resistance, and the Impact of Social Determinants of Health in HIV-1 Patients in the US

Original Paper

Internalized HIV Stigma and Pain among Women with HIV in the United States: The Mediating Role of Depressive Symptoms

Original Paper

A Randomized Controlled Trial of a Texting Intervention to Maintain Sexual Risk Reduction with Clients Among Female Sex Workers in Tijuana and Ciudad Juarez, Mexico

Editorial

Core Elements of a National COVID-19 Strategy: Lessons Learned from the US National HIV/AIDS Strategy

Original Paper

Practices and Obstacles to Provider-Initiated HIV Testing and Counseling (PITC) Among Healthcare Providers in Côte d’Ivoire

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Herzinfarkt mit 85 – trotzdem noch intensive Lipidsenkung?

16.05.2024 Hypercholesterinämie Nachrichten

Profitieren nach einem akuten Myokardinfarkt auch Betroffene über 80 Jahre noch von einer intensiven Lipidsenkung zur Sekundärprävention? Um diese Frage zu beantworten, wurden jetzt Registerdaten aus Frankreich ausgewertet.

ADHS-Medikation erhöht das kardiovaskuläre Risiko

16.05.2024 Herzinsuffizienz Nachrichten

Erwachsene, die Medikamente gegen das Aufmerksamkeitsdefizit-Hyperaktivitätssyndrom einnehmen, laufen offenbar erhöhte Gefahr, an Herzschwäche zu erkranken oder einen Schlaganfall zu erleiden. Es scheint eine Dosis-Wirkungs-Beziehung zu bestehen.

Bei Herzinsuffizienz muss „Eisenmangel“ neu definiert werden!

16.05.2024 Herzinsuffizienz Nachrichten

Bei chronischer Herzinsuffizienz macht es einem internationalen Expertenteam zufolge wenig Sinn, die Diagnose „Eisenmangel“ am Serumferritin festzumachen. Das Team schlägt vor, sich lieber an die Transferrinsättigung zu halten.

Erstmanifestation eines Diabetes-Typ-1 bei Kindern: Ein Notfall!

16.05.2024 DDG-Jahrestagung 2024 Kongressbericht

Manifestiert sich ein Typ-1-Diabetes bei Kindern, ist das ein Notfall – ebenso wie eine diabetische Ketoazidose. Die Grundsäulen der Therapie bestehen aus Rehydratation, Insulin und Kaliumgabe. Insulin ist das Medikament der Wahl zur Behandlung der Ketoazidose.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise