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15.08.2023 | Chest

Pulmonary MRI with ultra-short TE using single- and dual-echo methods: comparison of capability for quantitative differentiation of non- or minimally invasive adenocarcinomas from other lung cancers with that of standard-dose thin-section CT

verfasst von: Yoshiharu Ohno, Masao Yui, Kaori Yamamoto, Masato Ikedo, Yuka Oshima, Nayu Hamabuchi, Satomu Hanamatsu, Hiroyuki Nagata, Takahiro Ueda, Hirotaka Ikeda, Daisuke Takenaka, Takeshi Yoshikawa, Yoshiyuki Ozawa, Hiroshi Toyama

Erschienen in: European Radiology | Ausgabe 2/2024

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Abstract

Objective

The purpose of this study was thus to compare capabilities for quantitative differentiation of non- and minimally invasive adenocarcinomas from other of pulmonary MRIs with ultra-short TE (UTE) obtained with single- and dual-echo techniques (UTE-MRI_Single and UTE-MRI_Dual) and thin-section CT for stage IA lung cancer patients.

Methods

Ninety pathologically diagnosed stage IA lung cancer patients who underwent thin-section standard-dose CT, UTE-MRI_Single, and UTE-MRI_Dual, surgical treatment and pathological examinations were included in this retrospective study. The largest dimension (D_long), solid portion (solid D_long), and consolidation/tumor (C/T) ratio of each nodule were assessed. Two-tailed Student’s t-tests were performed to compare all indexes obtained with each method between non- and minimally invasive adenocarcinomas and other lung cancers. Receiver operating characteristic (ROC)-based positive tests were performed to determine all feasible threshold values for distinguishing non- or minimally invasive adenocarcinoma (MIA) from other lung cancers. Sensitivity, specificity, and accuracy were then compared by means of McNemar’s test.

Results

Each index showed significant differences between the two groups (p < 0.0001). Specificities and accuracies of solid D_long for UTE-MRI_{Dual2nd echo} and CT_Mediastinal were significantly higher than those of solid D_long for UTE-MRI_Single and UTE-MRI_{Dual1st echo} and all C/T ratios except CT_Mediastinal (p < 0.05). Moreover, the specificities and accuracies of solid D_long and C/T ratio were significantly higher than those of D_long for each method (p < 0.05).

Conclusion

Pulmonary MRI with UTE is considered at least as valuable as thin-section CT for quantitative differentiation of non- and minimally invasive adenocarcinomas from other stage IA lung cancers.

Clinical relevance statement

Pulmonary MRI with UTE’s capability for quantitative differentiation of non- and minimally invasive adenocarcinomas from other lung cancers in stage IA lung cancer patients is equal or superior to that of thin-section CT.

Key Points

• Correlations were excellent for pathologically examined nodules with the largest dimensions (D_long) and a solid component (solid D_long) for all indexes (0.95 ≤ r ≤ 0.99, p < 0.0001).

• Pathologically examined D_long and solid D_long obtained with all methods showed significant differences between non- and minimally invasive adenocarcinomas and other lung cancers (p < 0.0001).

• Solid tumor components are most accurately measured by UTE-MRI_{Dual2nd echo} and CT_Mediastinal, whereas the ground-glass component is imaged by UTE-MRI_{Dual1st echo} and CT_lung with high accuracy. UTE-MRI_Dual predicts tumor invasiveness with 100% sensitivity and 87.5% specificity at a C/T threshold of 0.5.

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Titel: Pulmonary MRI with ultra-short TE using single- and dual-echo methods: comparison of capability for quantitative differentiation of non- or minimally invasive adenocarcinomas from other lung cancers with that of standard-dose thin-section CT
verfasst von: Yoshiharu Ohno
Masao Yui
Kaori Yamamoto
Masato Ikedo
Yuka Oshima
Nayu Hamabuchi
Satomu Hanamatsu
Hiroyuki Nagata
Takahiro Ueda
Hirotaka Ikeda
Daisuke Takenaka
Takeshi Yoshikawa
Yoshiyuki Ozawa
Hiroshi Toyama
Publikationsdatum: 15.08.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 2/2024
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-023-10105-4

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Pulmonary MRI with ultra-short TE using single- and dual-echo methods: comparison of capability for quantitative differentiation of non- or minimally invasive adenocarcinomas from other lung cancers with that of standard-dose thin-section CT