The online version of this article (doi:10.1186/1475-2875-11-186) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
All authors contributed to meta-analysis of publications. CW drafted the text. All authors read and approved the final manuscript.
A recent paper in Malaria Journal suggests that a high proportion of Plasmodium falciparum isolates found in travellers returning from a range of African countries carry the PfATP6 A623E S769N haplotype, and that this genotype is associated with artemether resistance. Such a finding would represent a substantial departure from the extensive literature reporting these individual mutations to be very rare, with the double mutation never documented. The number of isolates screened to obtain these double mutants is unstated, but highly relevant, not least because selection of isolates could have introduced significant confounders, such as timing of in vitro testing. An additional concern relates to the location of sequencing primers used to assess these positions. In the absence of clear information on these fundamental questions it would be appropriate to treat the findings with caution.
Authors’ original file for figure 112936_2012_2439_MOESM1_ESM.pdf
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- Questions over high frequency of mutant PfATP6 haplotypes in traveller isolates
Charles J Woodrow
Kate B Gardner
Leyla Y Bustamante
- BioMed Central
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