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Inflammopharmacology

Erschienen in:

19.12.2023 | Original Article

Rapamycin can alleviate the submandibular gland pathology of Sjögren's syndrome by limiting the activation of cGAS–STING signaling pathway

verfasst von: Wen Zhu, Yabei Wang, Yin Guan, Yun Lu, Yehui Li, Lixia sun, Yue Wang

Erschienen in: Inflammopharmacology | Ausgabe 2/2024

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Abstract

Background

Sjögren’s Syndrome (SS) is also known as autoimmune exocrine gland disease. Previous studies have confirmed that adaptive immunity plays an important role in the development of this disease. But less is known about the role of the innate immune system.

Methods

To identify the core pathways, and local infiltrated immune cells in the local immune microenvironment of SS. We verified the activation of these core genes and core signaling pathways in SS model mice by in vivo experiment and transcriptome sequencing.

Results

Finally, we identified 6 core genes EPSTI1, IFI44L, MX1, CXCL10, IFIT3, and IFI44. All the 6 genes had good diagnostic value. Based on multi-omics sequencing results and experimental studies, we found that cGAS–STING signaling pathway is most relevant to the pathogenesis of SS. By in vivo experiments, we verified that autophagy is the key brake to limit the activation of cGAS–STING signaling pathway.

Conclusions

Maladaptive activation of autophagy and cGAS–STING signaling pathway are central contributors to the SG pathogenesis of pSS patient. Regulating autophagy by rapamycin may be a possible treatment for Sjögren's syndrome in the future.

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Titel: Rapamycin can alleviate the submandibular gland pathology of Sjögren's syndrome by limiting the activation of cGAS–STING signaling pathway
verfasst von: Wen Zhu
Yabei Wang
Yin Guan
Yun Lu
Yehui Li
Lixia sun
Yue Wang
Publikationsdatum: 19.12.2023
Verlag: Springer International Publishing
Erschienen in: Inflammopharmacology / Ausgabe 2/2024
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-023-01393-9

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Rapamycin can alleviate the submandibular gland pathology of Sjögren's syndrome by limiting the activation of cGAS–STING signaling pathway

Abstract

Background

Methods

Results

Conclusions

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Springer Medizin

Abstract

Background

Methods

Results

Conclusions

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