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16.10.2019 | Original Article - Tumor - Other

Recurrence or neurological loss? Resection mode selection for patients with large sacral chordoma: an analysis of prognostic factors and quality of life

verfasst von: Xin Gao, Qi Jia, Xiaopan Cai, Chenglong Zhao, Jiaxiang Yang, Lianfeng Dong, Guangjian Bai, Baoquan Xin, Wei Wan, Tielong Liu, Jianru Xiao

Erschienen in: Acta Neurochirurgica | Ausgabe 12/2019

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Abstract

Background

Surgical resection represents the main therapeutic method for sacral chordoma, but plans for resection mode must weigh neurological loss against complete tumor excision, a difficult balance to strike. The purpose of this study was to provide useful information contributing to surgical decision making in sacral chordoma.

Methods

A retrospective review was performed on 47 patients with large sacral chordoma. Prognostic factors affecting recurrence-free survival (RFS) and overall survival (OS) were analyzed using the Kaplan–Meier method and Cox proportional hazards model. Quality of life was assessed by the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire and compared using Student’s t test.

Results

Resection mode was the independent prognostic factor affecting RFS, while independent prognostic factors affecting OS were resection mode and postoperative recurrence. As for quality of life, the en bloc resection group showed a higher score in emotional well-being, while the piecemeal resection group scored better in function well-being. No significant difference was identified in total the FACT-G score between two groups.

Conclusions

On the one hand, en bloc resection showed huge advantages in disease control for sacral chordoma. On the other hand, despite the unsatisfaction in functional well-being, en bloc resection did not sacrifice quality of life significantly in terms of the total FACT-G score.

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Titel: Recurrence or neurological loss? Resection mode selection for patients with large sacral chordoma: an analysis of prognostic factors and quality of life
verfasst von: Xin Gao
Qi Jia
Xiaopan Cai
Chenglong Zhao
Jiaxiang Yang
Lianfeng Dong
Guangjian Bai
Baoquan Xin
Wei Wan
Tielong Liu
Jianru Xiao
Publikationsdatum: 16.10.2019
Verlag: Springer Vienna
Erschienen in: Acta Neurochirurgica / Ausgabe 12/2019
Print ISSN: 0001-6268
Elektronische ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-019-04072-3

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Recurrence or neurological loss? Resection mode selection for patients with large sacral chordoma: an analysis of prognostic factors and quality of life