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Pediatric Nephrology

Erschienen in:

22.07.2017 | Review

Regenerative medicine in kidney disease: where we stand and where to go

verfasst von: Fernanda T. Borges, Nestor Schor

Erschienen in: Pediatric Nephrology | Ausgabe 9/2018

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Abstract

The kidney is a complex organ with more than 20 types of specialized cells that play an important role in maintaining the body’s homeostasis. The epithelial tubular cell is formed during embryonic development and has little proliferative capacity under physiological conditions, but after acute injury the kidney does have regenerative capacity. However, after repetitive or severe lesions, it may undergo a maladaptation process that predisposes it to chronic kidney injury. Regenerative medicine includes various repair and regeneration techniques, and these have gained increasing attention in the scientific literature. In the future, not only will these techniques contribute to the repair and regeneration of the human kidney, but probably also to the construction of an entire organ. New mechanisms studied for kidney regeneration and repair include circulating stem cells as mesenchymal stromal/stem cells and their paracrine mechanisms of action; renal progenitor stem cells; the leading role of tubular epithelial cells in the tubular repair process; the study of zebrafish larvae to understand the process of nephron development, kidney scaffold and its repopulation; and, finally, the development of organoids. This review elucidates where we are in terms of current scientific knowledge regarding these mechanisms and the promises of future scientific perspectives.

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Titel: Regenerative medicine in kidney disease: where we stand and where to go
verfasst von: Fernanda T. Borges
Nestor Schor
Publikationsdatum: 22.07.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 9/2018
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-017-3754-9

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