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Archives of Virology

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01.09.2015 | Brief Report

Repurposing of rutin for the inhibition of norovirus replication

verfasst von: Nicolas Chéron, Chenchen Yu, Abimbola O. Kolawole, Eugene I. Shakhnovich, Christiane E. Wobus

Erschienen in: Archives of Virology | Ausgabe 9/2015

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Abstract

Drug repurposing is a strategy employed to circumvent some of the bottlenecks involved in drug development, such as the cost and time needed for developing new molecular entities. Noroviruses cause recurrent epidemics and sporadic outbreaks of gastroenteritis associated with significant mortality and economic costs, but no treatment has been approved to date. Herein, a library of molecules previously used in humans was screened to find compounds with anti-noroviral activity. Antiviral testing for four selected compounds against murine norovirus infection revealed that rutin has anti-murine norovirus activity in cell-based assays.

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Titel: Repurposing of rutin for the inhibition of norovirus replication
verfasst von: Nicolas Chéron
Chenchen Yu
Abimbola O. Kolawole
Eugene I. Shakhnovich
Christiane E. Wobus
Publikationsdatum: 01.09.2015
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 9/2015
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-015-2495-y

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