Erschienen in:
06.06.2020 | Case Report
Resected High-Risk Rectal GIST Harboring NTRK1 Fusion: a Case Report and Review of the Literature
verfasst von:
Renata D’Alpino Peixoto, Bruno Amaral Medeiros, Eduardo Henrique Cronemberger
Erschienen in:
Journal of Gastrointestinal Cancer
|
Ausgabe 1/2021
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Excerpt
Gastrointestinal stromal tumors (GISTs) are the most common malignant mesenchymal tumors in the gastrointestinal tract and arise from the intestinal pacemaker cells of Cajal. They are most often encountered in the stomach, followed by the small intestine. Nonetheless, GISTs may arise in many gastrointestinal sites and peritoneal cavity, including the colon and rectum [
1]. Approximately 80–90% of GISTs harbor gain-of-function mutations either in the KIT (70–80%) or platelet-derived growth factor receptor alpha (
PDGFRA) gene (5–10%), which are responsible for their proliferation [
2,
3]. Mutations in these tyrosine kinase receptors result in ligand-independent kinase activation, resulting in cellular proliferation and oncogenesis [
2,
3]. …