nach oben

Graefe's Archive for Clinical and Experimental Ophthalmology

Erschienen in:

01.11.2014 | Glaucoma

Retinal vessel diameter in normal-tension glaucoma patients with asymmetric progression

verfasst von: Tae-Eun Lee, Yong Yeon Kim, Chungkwon Yoo

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 11/2014

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To investigate the longitudinal changes in the central retinal vessel diameter in asymmetric progressive normal-tension glaucoma (NTG) patients.

Methods

This study included 27 patients with bilateral NTG without any systemic vascular disease who showed glaucomatous progression in one eye at the mean follow-up of 24.3 months (range, 18–29 months). Progression was determined by the development of new retinal nerve fiber layer (RNFL) defects or widening of pre-existing defects on red-free RNFL photographs. The central retinal arteriolar equivalent (CRAE) and the central retinal venular equivalent (CRVE) were measured at baseline and at the mean follow-up of 24.3 months. We classified the eyes of each patient as either progressed or stable eyes, and compared the differences and changes in the CRAE and CRVE.

Results

No significant inter-eye difference was observed at baseline in the mean CRAE (167.5 ± 22.2 μm vs. 168.2 ± 15.5 μm, p = 0.809) and in the mean CRVE (276.3 ± 18.2 μm vs. 281.6 ± 21.9 μm, p = 0.267) between the progressed and stable eyes. There were significant changes in CRAE in the progressed eyes between baseline and 2 years after baseline (from 167.5 ± 22.2 μm to 146.9 ± 18.0 μm, p < 0.0001), but there were no significant changes in the stable eyes (from 168.2 ± 15.5 μm to 167.5 ± 14.8 μm, p = 0.084).

Conclusions

In our series of NTG patients with asymmetric progression, central retinal artery diameter decreased over time in the progressed eyes, whereas no significant decrease in the central retinal artery diameter was seen in the stable eyes.

Collaborative Normal-Tension Glaucoma Study Group (1998) Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures. Am J Ophthalmol 126:487–497CrossRef

Flammer J, Orgül S, Costa VP et al (2002) The impact of ocular blood flow in glaucoma. Prog Retin Eye Res 21:359–393PubMedCrossRef

Shoshani YZ, Harris A, Shoja MM et al (2012) Endothelin and its suspected role in the pathogenesis and possible treatment of glaucoma. Curr Eye Res 37:1–11. doi:10.3109/02713683.2011.622849 PubMedCrossRef

Emre M, Orgül S, Gugleta K, Flammer J (2004) Ocular blood flow alteration in glaucoma is related to systemic vascular dysregulation. Br J Ophthalmol 88:662–666PubMedCentralPubMedCrossRef

Hayreh SS (2001) The blood supply of the optic nerve head and the evaluation of it—myth and reality. Prog Retin Eye Res 20:563–593PubMedCrossRef

Mackenzie PJ, Cioffi GA (2008) Vascular anatomy of the optic nerve head. Can J Ophthalmol 43:308–312. doi:10.3129/i08-042 PubMedCrossRef

Papastathopoulos KI, Jonas JB (1999) Follow-up of focal narrowing of retinal arterioles in glaucoma. Br J Ophthalmol 83:285–289PubMedCentralPubMedCrossRef

Rader J, Feuer WJ, Anderson DR (1994) Peripapillary vasoconstriction in the glaucomas and the anterior ischemic optic neuropathies. Am J Ophthalmol 117:72–80PubMedCrossRef

Chang M, Yoo C, Kim SW, Kim YY (2011) Retinal vessel diameter, retinal nerve fiber layer thickness, and intraocular pressure in Korean patients with normal-tension glaucoma. Am J Ophthalmol 151:100–105.e1. doi:10.1016/j.ajo.2010.07.025 PubMedCrossRef

10.

Lee JY, Yoo C, Park J, Kim YY (2012) Retinal vessel diameter in young patients with open-angle glaucoma: comparison between high-tension and normal-tension glaucoma. Acta Ophthalmol 90:e570–e571. doi:10.1111/j.1755-3768.2011.02371.x PubMedCrossRef

11.

Kawasaki R, Wang JJ, Rochtchina E et al (2013) Retinal vessel caliber is associated with the 10-year incidence of glaucoma: the Blue Mountains Eye Study. Ophthalmology 120:84–90. doi:10.1016/j.ophtha.2012.07.007 PubMedCrossRef

12.

Anderson DR PV (1999) Automated static perimetry. St. Louis: Mosby, p 164

13.

Hoyt WF, Frisén L, Newman NM (1973) Fundoscopy of nerve fiber layer defects in glaucoma. Invest Ophthalmol 12:814–829PubMed

14.

Quigley HA, Katz J, Derick RJ et al (1992) An evaluation of optic disc and nerve fiber layer examinations in monitoring progression of early glaucoma damage. Ophthalmology 99:19–28PubMedCrossRef

15.

Suh MH, Kim DM, Kim YK et al (2010) Patterns of progression of localized retinal nerve fibre layer defect on red-free fundus photographs in normal-tension glaucoma. Eye (Lond) 24:857–863. doi:10.1038/eye.2009.209 CrossRef

16.

Boden C, Blumenthal EZ, Pascual J et al (2004) Patterns of glaucomatous visual field progression identified by three progression criteria. Am J Ophthalmol 138:1029–1036. doi:10.1016/j.ajo.2004.07.003 PubMedCrossRef

17.

Hubbard LD, Brothers RJ, King WN et al (1999) Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. Ophthalmology 106:2269–2280PubMedCrossRef

18.

Knudtson MD, Lee KE, Hubbard LD et al (2003) Revised formulas for summarizing retinal vessel diameters. Curr Eye Res 27:143–149PubMedCrossRef

19.

Kim JM, Sae Kim M, Ju Jang H et al (2012) The association between retinal vessel diameter and retinal nerve fiber layer thickness in asymmetric normal tension glaucoma patients. Invest Ophthalmol Vis Sci 53:5609–5614. doi:10.1167/iovs.12-9783 PubMedCrossRef

20.

Jonas JB, Nguyen XN, Naumann GO (1989) Parapapillary retinal vessel diameter in normal and glaucoma eyes. I. Morphometric data. Invest Ophthalmol Vis Sci 30:1599–1603PubMed

21.

Jonas JB, Naumann GO (1989) Parapapillary retinal vessel diameter in normal and glaucoma eyes. II. Correlations. Invest Ophthalmol Vis Sci 30:1604–1611PubMed

22.

Vannas S, Tarkkanen A (1960) Retinal vein occlusion and glaucoma. Tonographic study of the incidence of glaucoma and of its prognostic significance. Br J Ophthalmol 44:583–589PubMedCentralPubMedCrossRef

23.

Ikram MK, de Jong FJ, Vingerling JR et al (2004) Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam Study. Invest Ophthalmol Vis Sci 45:2129–2134PubMedCrossRef

24.

Wong TY, Islam FMA, Klein R et al (2006) Retinal vascular caliber, cardiovascular risk factors, and inflammation: the multi-ethnic study of atherosclerosis (MESA). Invest Ophthalmol Vis Sci 47:2341–2350. doi:10.1167/iovs.05-1539 PubMedCentralPubMedCrossRef

25.

Cherecheanu AP, Garhofer G, Schmidl D et al (2013) Ocular perfusion pressure and ocular blood flow in glaucoma. Curr Opin Pharmacol 13:36–42. doi:10.1016/j.coph.2012.09.003 PubMedCentralPubMedCrossRef

26.

Mozaffarieh M, Flammer J (2013) New insights in the pathogenesis and treatment of normal tension glaucoma. Curr Opin Pharmacol 13:43–49. doi:10.1016/j.coph.2012.10.001 PubMedCrossRef

27.

Mitchell P, Smith W, Chey T, Healey PR (1997) Open-angle glaucoma and diabetes: the Blue Mountains eye study, Australia. Ophthalmology 104:712–718PubMedCrossRef

28.

Bonomi L, Marchini G, Marraffa M et al (2000) Vascular risk factors for primary open-angle glaucoma: the Egna-Neumarkt Study. Ophthalmology 107:1287–1293PubMedCrossRef

29.

Leske MC, Wu S-Y, Hennis A et al (2008) Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. Ophthalmology 115:85–93. doi:10.1016/j.ophtha.2007.03.017 PubMedCrossRef

30.

Quigley HA, West SK, Rodriguez J et al (2001) The prevalence of glaucoma in a population-based study of Hispanic subjects: Proyecto VER. Arch Ophthalmol 119:1819–1826PubMedCrossRef

31.

Tielsch JM, Katz J, Sommer A et al (1995) Hypertension, perfusion pressure, and primary open-angle glaucoma. A population-based assessment. Arch Ophthalmol 113:216–221PubMedCrossRef

32.

Wang JJ, Mitchell P, Smith W (1997) Is there an association between migraine headache and open-angle glaucoma? Findings from the Blue Mountains Eye Study. Ophthalmology 104:1714–1719PubMedCrossRef

33.

Broadway DC, Drance SM (1998) Glaucoma and vasospasm. Br J Ophthalmol 82:862–870PubMedCentralPubMedCrossRef

34.

Flammer J, Konieczka K, Flammer AJ (2013) The primary vascular dysregulation syndrome: implications for eye diseases. EPMA J 4:14. doi:10.1186/1878-5085-4-14 PubMedCentralPubMedCrossRef

35.

Gugleta K, Waldmann N, Polunina A et al (2013) Retinal neurovascular coupling in patients with glaucoma and ocular hypertension and its association with the level of glaucomatous damage. Graefes Arch Clin Exp Ophthalmol 251:1577–1585. doi:10.1007/s00417-013-2276-9 PubMedCrossRef

36.

Olafsdottir OB, Hardarson SH, Gottfredsdottir MS et al (2011) Retinal oximetry in primary open-angle glaucoma. Invest Ophthalmol Vis Sci 52:6409–6413. doi:10.1167/iovs.10-6985 PubMedCrossRef

37.

Olafsdottir OB, Vandewalle E, Abegão Pinto L et al (2014) Retinal oxygen metabolism in healthy subjects and glaucoma patients. Br J Ophthalmol 98:329–333. doi:10.1136/bjophthalmol-2013-303162 PubMedCrossRef

38.

Vandewalle E, Abegão Pinto L, Olafsdottir OB et al (2014) Oximetry in glaucoma: correlation of metabolic change with structural and functional damage. Acta Ophthalmol 92:105–110. doi:10.1111/aos.12011 PubMedCrossRef

39.

Jonas JB, Fernández MC, Naumann GO (1991) Parapapillary atrophy and retinal vessel diameter in nonglaucomatous optic nerve damage. Invest Ophthalmol Vis Sci 32:2942–2947PubMed

40.

Leske MC, Heijl A, Hussein M et al (2003) Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial. Arch Ophthalmol 121:48–56PubMedCrossRef

41.

De Moraes CGV, Prata TS, Tello C et al (2009) Glaucoma with early visual field loss affecting both hemifields and the risk of disease progression. Arch Ophthalmol 127:1129–1134. doi:10.1001/archophthalmol.2009.165 PubMedCrossRef

42.

Teng CCV, De Moraes CG, Prata TS et al (2010) Beta-Zone parapapillary atrophy and the velocity of glaucoma progression. Ophthalmology 117:909–915. doi:10.1016/j.ophtha.2009.10.016 PubMedCrossRef

43.

Kim M, Kim DM, Park KH et al (2013) Intraocular pressure reduction with topical medications and progression of normal-tension glaucoma: a 12-year mean follow-up study. Acta Ophthalmol 91:e270–e275. doi:10.1111/aos.12082 PubMedCrossRef

44.

Nakagami T, Yamazaki Y, Hayamizu F (2006) Prognostic factors for progression of visual field damage in patients with normal-tension glaucoma. Jpn J Ophthalmol 50:38–43. doi:10.1007/s10384-005-0273-1 PubMedCrossRef

45.

Hao H, Sasongko MB, Wong TY et al (2012) Does retinal vascular geometry vary with cardiac cycle? Invest Ophthalmol Vis Sci 53:5799–5805. doi:10.1167/iovs.11-9326 PubMedCrossRef

46.

Reber F, Gersch U, Funk RW (2003) Blockers of carbonic anhydrase can cause increase of retinal capillary diameter, decrease of extracellular and increase of intracellular pH in rat retinal organ culture. Graefes Arch Clin Exp Ophthalmol 241:140–148. doi:10.1007/s00417-002-0560-1 PubMedCrossRef

47.

Kehler AK, Holmgaard K, Hessellund A et al (2007) Variable involvement of the perivascular retinal tissue in carbonic anhydrase inhibitor induced relaxation of porcine retinal arterioles in vitro. Invest Ophthalmol Vis Sci 48:4688–4693. doi:10.1167/iovs.07-0048 PubMedCrossRef

48.

Howard KP, Klein BEK, Dreyer JO et al (2014) Cross-sectional associations of medication and supplement use with retinal vascular diameter in the Beaver Dam Eye Study. JAMA Ophthalmol 132:23–31. doi:10.1001/jamaophthalmol.2013.6326 PubMedCrossRef

Titel: Retinal vessel diameter in normal-tension glaucoma patients with asymmetric progression
verfasst von: Tae-Eun Lee
Yong Yeon Kim
Chungkwon Yoo
Publikationsdatum: 01.11.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 11/2014
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-014-2756-6

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Retinal vessel diameter in normal-tension glaucoma patients with asymmetric progression

Abstract

Purpose

Methods

Results

Conclusions

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 11/2014

Next generation sequencing uncovers a missense mutation in COL4A1 as the cause of familial retinal arteriolar tortuosity

Investigation of blood flow regulation and oxygen saturation of the retinal vessels in primary open-angle glaucoma

Early axonal damage detection by ganglion cell complex analysis with optical coherence tomography in nonarteritic anterior ischaemic optic neuropathy

Evaluation of congenital excavated optic disc anomalies with spectral-domain and swept-source optical coherence tomography

Soluble vascular endothelial growth factor receptor-3 suppresses allosensitization and promotes corneal allograft survival

The effect of posterior corneal flat meridian and astigmatism amount on the total corneal astigmatism estimated from anterior corneal measurements

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde