Background
Methods
Patients and materials
Statistical analysis
Results
Characteristics of patients with simple febrile seizure
Men/Women | 73 (54.9)/60 (45.1) |
Age (year) | 2.1 [1.7 ̶ 3.1] |
Family history of febrile seizure epilepsy | 19 (14.3)/1 (0.8) |
Past history of febrile convulsion | 40 (30.1) |
Developmental delay | 4 (3.0) |
Mean seizure duration (minute) | 2.37 ± 2.20 |
Seizure longer than 15 min | 0 (0) |
Multiple seizure episodes | 9 (6.8) |
Seizure type (Focal/Generalized) | 0 (0) / 133 (100) |
Comparison of laboratory values
Group | Febrile seizure (n = 133) | Control (n = 141) | P-value |
---|---|---|---|
Age (year) | 2.1 [1.7 ̶ 3.1] | 1.9 [1.5 ̶ 3.0] | 0.128 |
Men/Women | 73 (54.9)/60 (45.1) | 77 (54.6)/64 (45.4) | 1.000 |
Hypocalcemiaa | 13 (11.6) | 14 (10.6) | 0.763 |
Hypomagnesemia | 57 (42.9) | 7 (6.9) | < 0.001* |
Serum iMg2+ (mmol/L) | 0.5 ± 0.1 | 0.6 ± 0.0 | |
Hyponatremia | 28 (21.1) | 7 (5.0) | < 0.001* |
Serum Na (mmol/L) | 136.0 [135.0;137.0] | 138.0 [137.0; 139.0] | |
Hypokalemia | 3 (2.3) | 5 (3.5) | 0.783 |
Predicting independent risk factors for developing febrile seizure
Univariate Analysis | Multivariate Analysis | |||||
---|---|---|---|---|---|---|
Crude OR | 95% CI | P-value | Adjusted OR | 95% CI | P-value | |
Age | 1.09 | 0.89–1.34 | 0.4189 | |||
Sex | 0.99 | 0.61–1.59 | 0.9632 | |||
Hypocalcemia | 1.23 | 0.55–2.75 | 0.6120 | |||
Hypomagnesemia | 14.36 | 6.24–33.05 | < 0.001 | 22.12 | 9.23–53.02 | < 0.001 |
Hyponatremia | 5.10 | 2.15–12.14 | 0.0002 | 4.81 | 1.67–13.85 | 0.0036 |
Hypokalemia | 0.63 | 0.15–2.68 | 0.5294 |
Hypomagnesemia
Variables | Serum levels of ionized Mg2+ | P-value | |
---|---|---|---|
< 0.51 mmol/L (n = 60) | ≥ 0.51 mmol/L (n = 73) | ||
Men/Women | 33 (55.0)/27 (45.0) | 40 (54.8)/33 (45.2) | 1.000 |
Age (year) | 2.2 [1.7; 3.4] | 2.1 [1.7; 3.0] | 0.741 |
Family history of epilepsy | 0 | 1 (1.4) | 1.000 |
Family history of FS | 10 (16.7) | 9 (12.3) | 0.644 |
Past history of FS | 18 (30.0) | 22 (30.1) | 1.000 |
Developmental delay | 0 | 4 (5.5) | 0.183 |
Multiple seizure episodes | 5 (8.3) | 4 (5.5) | 0.760 |
Seizure duration (min) | 2.0 [1.0; 3.0] | 1.0 [1.0; 3.0] | 0.366 |
Seizure longer than 5 min | 2 (3.3) | 5 (6.8) | 0.608 |