Erschienen in:
12.02.2024 | Invited Commentary
Risk Stratification in Primary Sclerosing Cholangitis: Does Size Matter?
verfasst von:
Nasir Hussain, Palak J. Trivedi
Erschienen in:
Digestive Diseases and Sciences
|
Ausgabe 4/2024
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Excerpt
Primary sclerosing cholangitis (PSC) is a chronic immune-mediated disease, characterized by inflammation and fibrosis of bile ducts, with consequent multifocal stricturing and chronic cholestasis. For most, the diagnosis is made via cholangiography, with contemporary clinical practice adopting magnetic resonance cholangiopancreatography (MRCP) as the imaging modality of choice. Imaging features of biliary irregularities and stricturing, alongside biochemical cholestasis, a history of inflammatory bowel disease (IBD), and exclusion of sclerosing cholangitis from secondary causes are in most cases sufficient to diagnose ‘classical’ or ‘large duct’ PSC [
1]. Given the lack of definitive medical therapy, classical PSC is invariably progressive, with liver transplantation the only life-extending intervention available to patients. …