The development of biosimilars has raised some concerns in certain aspects such as immunogenicity, antidrug antibodies formation, safety and efficacy issues. |
Given the paucity of data regarding the treatment of Behçet’s syndrome-related uveitis with biosimilars, we investigated the efficacy of SB5, an adalimumab biosimilar, in the management of this rare condition. |
SB5 displayed encouraging results by reducing uveitis relapses and controlling retinal vasculitis while allowing preservation of visual acuity. |
SB5 may constitute a valid option for effective management of Behçet’s syndrome-related uveitis. |
Introduction
Methods
Population and Study Design
Aims and Endpoints
Statistical Analysis
Results
Patient | Gender | Age (years) | Age at disease onset (years) | HLA B51 | Disease duration (years) | Characteristics of eye involvement | Mucosal involvement | Skin | CNS | PNS | Gut | Vascular | Joint | ISGC | Previous biologic treatments |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | F | 49 | 41 | + | 9 | Bilateral posterior uveitis | + | − | − | − | − | − | + | + | ANA, ADAo |
2 | M | 43 | 24 | + | 19 | Bilateral panuveitis | + | − | − | − | − | − | − | + | IFX |
3 | F | 67 | 44 | − | 23 | Bilateral panuveitis and retinal vasculitis | + | + | − | − | − | + | + | + | ETN, ANA |
4 | M | 56 | 36 | + | 20 | Bilateral panuveitis | + | + | − | − | − | − | − | + | IFX |
5 | M | 54 | 42 | + | 12 | Bilateral panuveitis | + | + | + | − | + | + | − | + | ANA, ADAo |
6 | M | 53 | 32 | − | 21 | Bilateral panuveitis | + | + | − | − | − | − | + | + | IFX, ADAo |
7 | M | 48 | 35 | + | 13 | Bilateral panuveitis | + | − | − | − | − | − | − | + | ADAo |
8 | M | 30 | 29 | + | 1 | Bilateral posterior uveitis and retinal vasculitis | + | + | − | − | − | − | + | + | – |