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01.10.2010 | Review | Ausgabe 5/2010

Breast Cancer Research 5/2010

Role of miR-10b in breast cancer metastasis

Zeitschrift:
Breast Cancer Research > Ausgabe 5/2010
Autor:
Li Ma
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​bcr2720) contains supplementary material, which is available to authorized users.

Competing interests

The author declares that they have no competing interests.

Abstract

Ninety percent of cancer-related mortality is caused by metastasis. Current cancer treatments can control many primary tumors but rarely stop the metastatic spread. Accumulating evidence demonstrates that miRNAs are involved in cancer initiation and progression. Furthermore, several miRNAs have been found to regulate metastasis. In particular, recent studies provide the first functional evidence that overexpression of a specific miRNA, miR-10b, can contribute to the development of metastasis, which can be exploited therapeutically in treating breast cancer metastasis in mice. Further in-depth analysis should provide more precise evaluation of the roles, mechanisms, and therapeutic utility of this miRNA in breast cancer.

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Authors’ original file for figure 1
13058_2010_2708_MOESM1_ESM.tiff
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