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Current Heart Failure Reports
Erschienen in: Current Heart Failure Reports 2/2023

27.02.2023

Role of the Renal Lymphatic System in Heart Failure

verfasst von: Husam M. Salah, Jan Biegus, Marat Fudim

Erschienen in: Current Heart Failure Reports | Ausgabe 2/2023

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Abstract

Purpose of Review

The lymphatic system plays a major but overlooked role in maintaining fluid homeostasis. Given the unique fluid homeostasis functions of the kidneys, dysregulation of the renal lymphatic system underlies the development of self-propagating congestive pathomechanisms. In this review, we outline the roles of the renal lymphatic system in heart failure (HF).

Recent Findings

Studies have uncovered several pathomechanisms involving the renal lymphatic system in congestive states, such as impaired interstitial draining by the renal lymphatic system, impaired structure and valves of renal lymphatics, lymphatic-induced increase in renal reabsorption of water and sodium, and development of albuminuria with proteinuria-induced renal lymphangiogenesis. These self-propagating mechanisms result in “renal tamponade” with manifestations of cardiorenal syndrome and inappropriate renal response to diuretics.

Summary

Dysregulation of the renal lymphatic system is integral to the development and progression of congestion in HF. Targeting renal lymphatics may provide a novel pathway to treat intractable congestion.
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Metadaten
Titel
Role of the Renal Lymphatic System in Heart Failure
verfasst von
Husam M. Salah
Jan Biegus
Marat Fudim
Publikationsdatum
27.02.2023
Verlag
Springer US
Erschienen in
Current Heart Failure Reports / Ausgabe 2/2023
Print ISSN: 1546-9530
Elektronische ISSN: 1546-9549
DOI
https://doi.org/10.1007/s11897-023-00595-0

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