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Cancer and Metastasis Reviews
Erschienen in: Cancer and Metastasis Reviews 4/2018

12.12.2018

Roles of the mitochondrial genetics in cancer metastasis: not to be ignored any longer

verfasst von: Thomas C. Beadnell, Adam D. Scheid, Carolyn J. Vivian, Danny R. Welch

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 4/2018

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Abstract

Mitochondrial DNA (mtDNA) encodes for only a fraction of the proteins that are encoded within the nucleus, and therefore has typically been regarded as a lesser player in cancer biology and metastasis. Accumulating evidence, however, supports an increased role for mtDNA impacting tumor progression and metastatic susceptibility. Unfortunately, due to this delay, there is a dearth of data defining the relative contributions of specific mtDNA polymorphisms (SNP), which leads to an inability to effectively use these polymorphisms to guide and enhance therapeutic strategies and diagnosis. In addition, evidence also suggests that differences in mtDNA impact not only the cancer cells but also the cells within the surrounding tumor microenvironment, suggesting a broad encompassing role for mtDNA polymorphisms in regulating the disease progression. mtDNA may have profound implications in the regulation of cancer biology and metastasis. However, there are still great lengths to go to understand fully its contributions. Thus, herein, we discuss the recent advances in our understanding of mtDNA in cancer and metastasis, providing a framework for future functional validation and discovery.
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Metadaten
Titel
Roles of the mitochondrial genetics in cancer metastasis: not to be ignored any longer
verfasst von
Thomas C. Beadnell
Adam D. Scheid
Carolyn J. Vivian
Danny R. Welch
Publikationsdatum
12.12.2018
Verlag
Springer US
Erschienen in
Cancer and Metastasis Reviews / Ausgabe 4/2018
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-018-9772-7

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