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01.12.2013

Serotonin receptor 1B genotype and hostility, anger and aggressive behavior through the lifespan: the Young Finns study

verfasst von: Christian Hakulinen, Markus Jokela, Mirka Hintsanen, Päivi Merjonen, Laura Pulkki-Råback, Ilkka Seppälä, Leo-Pekka Lyytikäinen, Terho Lehtimäki, Mika Kähönen, Jorma Viikari, Olli T. Raitakari, Liisa Keltikangas-Järvinen

Erschienen in: Journal of Behavioral Medicine | Ausgabe 6/2013

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Abstract

The serotonin system has been shown to be involved in the regulation of hostility, anger, and aggressive behavior. Previous molecular genetic studies suggest that the serotonin receptor 1B (HTR1B) rs6296 genotype might have a particular role in these types of behaviors. We examined whether HTR1B is related to hostility, anger, and aggressive behavior phenotypes over a lifespan and whether it modifies the connection between childhood aggressive behavior and adulthood hostility and anger. The participants were 967 women and men from a large population based sample (The Young Finns Study) with a 27-year follow-up. Childhood aggressive behavior was reported by the mother twice when the participants were 3 to 12 years of age. Adulthood hostility and anger were self-reported by the participants between ages 24 and 36. Childhood aggressive behavior predicted adulthood hostility over 27 years. HTR1B SNP rs6296 was associated with childhood aggressive behavior but not with adulthood anger or hostility. The HTR1B SNP rs6296 modified the association between childhood aggressive behavior and adulthood hostility. Aggressive behavior and hostility might form a life course pattern, and the HTR1B might contribute to a development of this pattern.

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Titel: Serotonin receptor 1B genotype and hostility, anger and aggressive behavior through the lifespan: the Young Finns study
verfasst von: Christian Hakulinen
Markus Jokela
Mirka Hintsanen
Päivi Merjonen
Laura Pulkki-Råback
Ilkka Seppälä
Leo-Pekka Lyytikäinen
Terho Lehtimäki
Mika Kähönen
Jorma Viikari
Olli T. Raitakari
Liisa Keltikangas-Järvinen
Publikationsdatum: 01.12.2013
Verlag: Springer US
Erschienen in: Journal of Behavioral Medicine / Ausgabe 6/2013
Print ISSN: 0160-7715
Elektronische ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-012-9452-y

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