Erschienen in:
01.06.2011 | Brief Report
Serotype-specific and cross-reactive neutralizing antibody responses in cynomolgus monkeys after infection with multiple dengue virus serotypes
verfasst von:
Mikako Ito, Yuko Katakai, Fumiko Ono, Hirofumi Akari, Ryo-zabro Mukai, Tomohiko Takasaki, Akira Kotaki, Ichiro Kurane
Erschienen in:
Archives of Virology
|
Ausgabe 6/2011
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Abstract
Neutralizing antibody responses were examined in monkeys after dengue virus infections. In monkeys that had been infected once or twice with DENV-2, neutralizing antibody was cross-reactive with all four serotypes after secondary or tertiary infection with DENV-3. In monkeys that had been inoculated with DENV-1 and DENV-2 in the primary and secondary infections, neutralizing antibody titers did not increase after tertiary infection with DENV-3. These results indicate that antibody responses after secondary and tertiary infections with different serotypes are cross-reactive with all four serotypes, consistent with what has been observed in humans, and suggest that monkeys are useful for determining neutralizing antibody responses.