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International Urology and Nephrology

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01.12.2007 | Original Article

Serum and urine cystatin C levels in children with post-pyelonephritic renal scarring: a pilot study

verfasst von: Hüray Islekel, Alper Soylu, Zekiye Altun, Uluç Yis, Mehmet Turkmen, Salih Kavukcu

Erschienen in: International Urology and Nephrology | Ausgabe 4/2007

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Abstract

Aim

We aimed to investigate in children with a history of acute pyelonephritis the influence of unilateral post-pyelonephritic renal scarring detected by DMSA scan on serum (S_CysC) and urine cystatin C (U_CysC) as well as upon other traditional markers of renal damage.

Methods

Children with DMSA proven pyelonephritis (n = 28) were grouped as either scar [+] (n = 19, unilateral renal scarring) or scar [−] (no scarring, n = 9). The scar [+] group was further divided into scar-1 (differential DMSA uptake, Δ_DMSA ≤ 10%; n = 8) and scar-2 (Δ_DMSA > 10%, n = 11) subgroups. S_CysC, serum creatinine, urine NAG, microalbumin, protein, fractional sodium excretion (FE_Na), tubular phosphate reabsorption (TPR), and U_CysC/Cr were evaluated in all patients.

Results

Neither S_CysC nor U_CysC were affected by age, height, and weight. scar [+] versus scar [−] groups and scar-1 versus scar-2 subgroups were not different with regard to all studied parameters. S_CysC did not increase in children with post-pyelonephritic unilateral renal scarring. However, 11 children with slightly increased (>0.95 mg/l) S_CysC levels in scar [+] group tended to have higher Δ_DMSA, albeit not significantly. Furthermore, U_CysC/Cr correlated well with urine microalbumin, NAG, and FE_Na in all children and the scar [+] group (P < 0.05).

Conclusion

S_CysC and U_CysC did not differ among pediatric patients with and without unilateral post-pyelonephritic renal scarring. However, Δ_DMSA uptake between the two kidneys tended to be raised in children with S_CysC levels higher than the reference ranges. Additionally, U_CysC/Cr exhibits parallelism with tubular functions.

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Titel: Serum and urine cystatin C levels in children with post-pyelonephritic renal scarring: a pilot study
verfasst von: Hüray Islekel
Alper Soylu
Zekiye Altun
Uluç Yis
Mehmet Turkmen
Salih Kavukcu
Publikationsdatum: 01.12.2007
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 4/2007
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-007-9260-4

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