Skip to main content
Erschienen in: International Urology and Nephrology 5/2014

01.05.2014 | Nephrology - Original Paper

Sexual dysfunction is more than twice as frequent in Danish female predialysis patients compared to age- and gender-matched healthy controls

verfasst von: Lotte Prescott, Inge Eidemak, Adrian P. Harrison, Stig Molsted

Erschienen in: International Urology and Nephrology | Ausgabe 5/2014

Einloggen, um Zugang zu erhalten

Abstract

Purpose

This study aimed to compare sexual dysfunction in Danish female predialysis patients with chronic kidney disease (CKD) stage 4–5 with age-matched healthy women in Denmark.

Methods

Twenty-seven adult female predialysis patients (CKD stage 4–5 ~ creatinine clearance ≤ 30 ml/min) without diagnosed depression and 54 randomly assigned healthy female controls completed the questionnaires Female Sexual Function Index, Female Sexual Distress Scale, and the Major Depression Inventory.

Results

Predialysis patients reported lower Female Sexual Function Index scores compared to the controls (14.2 ± 2.1 vs. 20.1 ± 1.7, respectively, p = 0.048), more frequent sexual distress (44 vs. 22 %, respectively, p = 0.044), and more frequent sexual dysfunction (41 vs. 17 %, respectively, p = 0.041). There was no difference between the patients’ and the controls’ depression scores (12.2 ± 2.2 vs. 8.6 ± 1.1, respectively, p = 0.180).

Conclusion

Sexual dysfunction was found to be more than two times as frequent in Danish female predialysis patients with CKD stage 4–5 compared to age- and gender-matched healthy controls, and this result emphasizes the need for attention towards sexual function in the treatment for CKD.
Literatur
1.
Zurück zum Zitat Basson R, Berman J, Burnett A et al (2000) Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. J Urol 163(3):888–893PubMed Basson R, Berman J, Burnett A et al (2000) Report of the international consensus development conference on female sexual dysfunction: definitions and classifications. J Urol 163(3):888–893PubMed
2.
Zurück zum Zitat Basson R, Schultz WW (2007) Sexual sequelae of general medical disorders. Lancet 369(9559):409–424PubMedCrossRef Basson R, Schultz WW (2007) Sexual sequelae of general medical disorders. Lancet 369(9559):409–424PubMedCrossRef
3.
Zurück zum Zitat Basok EK, Atsu N, Rifaioglu MM, Kantarci G, Yildirim A, Tokuc R (2009) Assessment of female sexual function and quality of life in predialysis, peritoneal dialysis, hemodialysis, and renal transplant patients. Int Urol Nephrol 41(3):473–481PubMedCrossRef Basok EK, Atsu N, Rifaioglu MM, Kantarci G, Yildirim A, Tokuc R (2009) Assessment of female sexual function and quality of life in predialysis, peritoneal dialysis, hemodialysis, and renal transplant patients. Int Urol Nephrol 41(3):473–481PubMedCrossRef
4.
Zurück zum Zitat Diemont WL, Vruggink PA, Meuleman EJ, Doesburg WH, Lemmens WA, Berden JH (2000) Sexual dysfunction after renal replacement therapy. Am J Kidney Dis 35(5):845–851PubMedCrossRef Diemont WL, Vruggink PA, Meuleman EJ, Doesburg WH, Lemmens WA, Berden JH (2000) Sexual dysfunction after renal replacement therapy. Am J Kidney Dis 35(5):845–851PubMedCrossRef
5.
Zurück zum Zitat Bellinghieri G, Santoro D, Mallamace A, Savica V (2008) Sexual dysfunction in chronic renal failure. J Nephrol 21(Suppl 13):S113–S117PubMed Bellinghieri G, Santoro D, Mallamace A, Savica V (2008) Sexual dysfunction in chronic renal failure. J Nephrol 21(Suppl 13):S113–S117PubMed
6.
Zurück zum Zitat Finkelstein FO, Shirani S, Wuerth D, Finkelstein SH (2007) Therapy Insight: sexual dysfunction in patients with chronic kidney disease. Nat Clin Pract Nephrol 3(4):200–207PubMedCrossRef Finkelstein FO, Shirani S, Wuerth D, Finkelstein SH (2007) Therapy Insight: sexual dysfunction in patients with chronic kidney disease. Nat Clin Pract Nephrol 3(4):200–207PubMedCrossRef
7.
Zurück zum Zitat Peng YS, Chiang CK, Kao TW et al (2005) Sexual dysfunction in female hemodialysis patients: a multicenter study. Kidney Int 68(2):760–765PubMed Peng YS, Chiang CK, Kao TW et al (2005) Sexual dysfunction in female hemodialysis patients: a multicenter study. Kidney Int 68(2):760–765PubMed
8.
Zurück zum Zitat Palmer BF (2003) Sexual dysfunction in men and women with chronic kidney disease and end-stage kidney disease. Adv Ren Replace Ther 10(1):48–60PubMedCrossRef Palmer BF (2003) Sexual dysfunction in men and women with chronic kidney disease and end-stage kidney disease. Adv Ren Replace Ther 10(1):48–60PubMedCrossRef
9.
Zurück zum Zitat Palmer BF (1999) Sexual dysfunction in uremia. J Am Soc Nephrol 10(6):1381–1388PubMed Palmer BF (1999) Sexual dysfunction in uremia. J Am Soc Nephrol 10(6):1381–1388PubMed
10.
Zurück zum Zitat Toorians AW, Janssen E, Laan E et al (1997) Chronic renal failure and sexual functioning: clinical status versus objectively assessed sexual response. Nephrol Dial Transplant 12(12):2654–2663PubMedCrossRef Toorians AW, Janssen E, Laan E et al (1997) Chronic renal failure and sexual functioning: clinical status versus objectively assessed sexual response. Nephrol Dial Transplant 12(12):2654–2663PubMedCrossRef
11.
Zurück zum Zitat Bailie GR, Elder SJ, Mason NA et al (2007) Sexual dysfunction in dialysis patients treated with antihypertensive or antidepressive medications: results from the DOPPS. Nephrol Dial Transplant 22(4):1163–1170PubMedCrossRef Bailie GR, Elder SJ, Mason NA et al (2007) Sexual dysfunction in dialysis patients treated with antihypertensive or antidepressive medications: results from the DOPPS. Nephrol Dial Transplant 22(4):1163–1170PubMedCrossRef
12.
Zurück zum Zitat Kimmel PL, Cukor D, Cohen SD, Peterson RA (2007) Depression in end-stage renal disease patients: a critical review. Adv Chronic Kidney Dis 14(4):328–334PubMedCrossRef Kimmel PL, Cukor D, Cohen SD, Peterson RA (2007) Depression in end-stage renal disease patients: a critical review. Adv Chronic Kidney Dis 14(4):328–334PubMedCrossRef
13.
Zurück zum Zitat Lopes AA, Bragg J, Young E et al (2002) Depression as a predictor of mortality and hospitalization among hemodialysis patients in the United States and Europe. Kidney Int 62(1):199–207PubMedCrossRef Lopes AA, Bragg J, Young E et al (2002) Depression as a predictor of mortality and hospitalization among hemodialysis patients in the United States and Europe. Kidney Int 62(1):199–207PubMedCrossRef
14.
Zurück zum Zitat National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 39(2 Suppl 1):S1–266 National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 39(2 Suppl 1):S1–266
15.
Zurück zum Zitat Rosen R, Brown C, Heiman J et al (2000) The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther 26(2):191–208PubMedCrossRef Rosen R, Brown C, Heiman J et al (2000) The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther 26(2):191–208PubMedCrossRef
16.
Zurück zum Zitat Wiegel M, Meston C, Rosen R (2005) The female sexual function index (FSFI): cross-validation and development of clinical cutoff scores. J Sex Marital Ther 31(1):1–20PubMedCrossRef Wiegel M, Meston C, Rosen R (2005) The female sexual function index (FSFI): cross-validation and development of clinical cutoff scores. J Sex Marital Ther 31(1):1–20PubMedCrossRef
17.
Zurück zum Zitat ter Kuile MM, Brauer M, Laan E (2006) The Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (FSDS): psychometric properties within a Dutch population. J Sex Marital Ther 32(4):289–304PubMedCrossRef ter Kuile MM, Brauer M, Laan E (2006) The Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (FSDS): psychometric properties within a Dutch population. J Sex Marital Ther 32(4):289–304PubMedCrossRef
18.
Zurück zum Zitat Derogatis LR, Rosen R, Leiblum S, Burnett A, Heiman J (2002) The Female Sexual Distress Scale (FSDS): initial validation of a standardized scale for assessment of sexually related personal distress in women. J Sex Marital Ther 28(4):317–330PubMedCrossRef Derogatis LR, Rosen R, Leiblum S, Burnett A, Heiman J (2002) The Female Sexual Distress Scale (FSDS): initial validation of a standardized scale for assessment of sexually related personal distress in women. J Sex Marital Ther 28(4):317–330PubMedCrossRef
19.
Zurück zum Zitat Bech P, Rasmussen NA, Olsen LR, Noerholm V, Abildgaard W (2001) The sensitivity and specificity of the Major Depression Inventory, using the Present State Examination as the index of diagnostic validity. J Affect Disord 66(2–3):159–164PubMedCrossRef Bech P, Rasmussen NA, Olsen LR, Noerholm V, Abildgaard W (2001) The sensitivity and specificity of the Major Depression Inventory, using the Present State Examination as the index of diagnostic validity. J Affect Disord 66(2–3):159–164PubMedCrossRef
20.
Zurück zum Zitat Olsen LR, Jensen DV, Noerholm V, Martiny K, Bech P (2003) The internal and external validity of the Major Depression Inventory in measuring severity of depressive states. Psychol Med 33(2):351–356PubMedCrossRef Olsen LR, Jensen DV, Noerholm V, Martiny K, Bech P (2003) The internal and external validity of the Major Depression Inventory in measuring severity of depressive states. Psychol Med 33(2):351–356PubMedCrossRef
21.
Zurück zum Zitat Miskulin DC, Athienites NV, Yan G et al (2001) Comorbidity assessment using the Index of Coexistent Diseases in a multicenter clinical trial. Kidney Int 60(4):1498–1510PubMedCrossRef Miskulin DC, Athienites NV, Yan G et al (2001) Comorbidity assessment using the Index of Coexistent Diseases in a multicenter clinical trial. Kidney Int 60(4):1498–1510PubMedCrossRef
23.
Zurück zum Zitat Hedayati SS, Bosworth HB, Kuchibhatla M, Kimmel PL, Szczech LA (2006) The predictive value of self-report scales compared with physician diagnosis of depression in hemodialysis patients. Kidney Int 69(9):1662–1668PubMedCrossRef Hedayati SS, Bosworth HB, Kuchibhatla M, Kimmel PL, Szczech LA (2006) The predictive value of self-report scales compared with physician diagnosis of depression in hemodialysis patients. Kidney Int 69(9):1662–1668PubMedCrossRef
24.
Zurück zum Zitat Vecchio M, Palmer SC, Tonelli M, Johnson DW, Strippoli GF (2012) Depression and sexual dysfunction in chronic kidney disease: a narrative review of the evidence in areas of significant unmet need. Nephrol Dial Transplant 27(9):3420–3428PubMedCrossRef Vecchio M, Palmer SC, Tonelli M, Johnson DW, Strippoli GF (2012) Depression and sexual dysfunction in chronic kidney disease: a narrative review of the evidence in areas of significant unmet need. Nephrol Dial Transplant 27(9):3420–3428PubMedCrossRef
25.
Zurück zum Zitat Meyer-Bahlburg HF, Dolezal C (2007) The female sexual function index: a methodological critique and suggestions for improvement. J Sex Marital Ther 33(3):217–224PubMedCrossRef Meyer-Bahlburg HF, Dolezal C (2007) The female sexual function index: a methodological critique and suggestions for improvement. J Sex Marital Ther 33(3):217–224PubMedCrossRef
26.
Zurück zum Zitat Laumann EO, Paik A, Rosen RC (1999) Sexual dysfunction in the United States: prevalence and predictors. JAMA 281(6):537–544PubMedCrossRef Laumann EO, Paik A, Rosen RC (1999) Sexual dysfunction in the United States: prevalence and predictors. JAMA 281(6):537–544PubMedCrossRef
Metadaten
Titel
Sexual dysfunction is more than twice as frequent in Danish female predialysis patients compared to age- and gender-matched healthy controls
verfasst von
Lotte Prescott
Inge Eidemak
Adrian P. Harrison
Stig Molsted
Publikationsdatum
01.05.2014
Verlag
Springer Netherlands
Erschienen in
International Urology and Nephrology / Ausgabe 5/2014
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-013-0566-0

Weitere Artikel der Ausgabe 5/2014

International Urology and Nephrology 5/2014 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Positiver FIT: Die Ursache liegt nicht immer im Dickdarm

27.05.2024 Blut im Stuhl Nachrichten

Immunchemischer Stuhltest positiv, Koloskopie negativ – in solchen Fällen kann die Blutungsquelle auch weiter proximal sitzen. Ein Forschungsteam hat nachgesehen, wie häufig und in welchen Lokalisationen das der Fall ist.

GLP-1-Agonisten können Fortschreiten diabetischer Retinopathie begünstigen

24.05.2024 Diabetische Retinopathie Nachrichten

Möglicherweise hängt es von der Art der Diabetesmedikamente ab, wie hoch das Risiko der Betroffenen ist, dass sich sehkraftgefährdende Komplikationen verschlimmern.

Mehr Lebenszeit mit Abemaciclib bei fortgeschrittenem Brustkrebs?

24.05.2024 Mammakarzinom Nachrichten

In der MONARCHE-3-Studie lebten Frauen mit fortgeschrittenem Hormonrezeptor-positivem, HER2-negativem Brustkrebs länger, wenn sie zusätzlich zu einem nicht steroidalen Aromatasehemmer mit Abemaciclib behandelt wurden; allerdings verfehlte der numerische Zugewinn die statistische Signifikanz.

ADT zur Radiatio nach Prostatektomie: Wenn, dann wohl länger

24.05.2024 Prostatakarzinom Nachrichten

Welchen Nutzen es trägt, wenn die Strahlentherapie nach radikaler Prostatektomie um eine Androgendeprivation ergänzt wird, hat die RADICALS-HD-Studie untersucht. Nun liegen die Ergebnisse vor. Sie sprechen für länger dauernden Hormonentzug.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.